Develpment of an educational program on biostatistics and clinical study design for medical researchers

• Project/Area Number: 15K08564
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical sociology
• Research Institution: Keio University
• Principal Investigator: Abe Takayuki 慶應義塾大学, 医学部(信濃町), 講師 (10594856)
• Co-Investigator(Kenkyū-buntansha): 中川 敦夫 慶應義塾大学, 医学部(信濃町), 特任講師 (30338149)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生物統計教育プログラム / 臨床研究デザイン / 医学統計学 / 生物統計学

Outline of Final Research Achievements

In Japan, the number of biostatisticians and experts of clinical trials is smaller than that in western countries, and educational programs on biostatistics and study design for clinical researchers are limited. In this research, a biostatistician and a clinician worked closely, and firstly evaluated the major topics in about 1000 biostatistical consultations and feedback information about statistics from seminar participants. We developed a practical and interactive educational program utilizing the latest information about such educational programs from overseas research organizations, and worked to improve it. The proportion of lab exercises using statistical software in our program is more than 50%, including generation of random allocation schedule, calculation of sample size, and interpretation of statistical output for analysis with linear models. We presented the research outcomes at some clinical societies and an international symposium that we organized using this grant.

Research Products

• [Journal Article] The updated network meta-analysis of neoadjuvant therapy for HER2-positive breast cancer (2018)
  • Author(s): Nakashoji Ayako、Hayashida Tetsu、Yokoe Takamichi、Maeda Hinako、Toyota Tomoka、Kikuchi Masayuki、Watanuki Rurina、Nagayama Aiko、Seki Tomoko、Takahashi Maiko、Abe Takayuki、Kitagawa Yuko
  • Journal Title: Cancer Treatment Reviews Volume: 62 Pages: 9-17
  • DOI: 10.1016/j.ctrv.2017.10.009
  • Peer Reviewed / Open Access
• [Journal Article] Real-world Efficacy and Safety of Nivolumab for Advanced Non?Small-cell Lung Cancer: A Retrospective Multicenter Analysis (2018)
  • Author(s): Kobayashi Keigo、Nakachi Ichiro、Naoki Katsuhiko、Satomi Ryosuke、Nakamura Morio、Inoue Takashi、Tateno Hiroki、Sakamaki Fumio、Sayama Koichi、Terashima Takeshi、Koh Hidefumi、Abe Takayuki、Nishino Makoto、Arai Daisuke、Yasuda Hiroyuki、Kawada Ichiro、Soejima Kenzo、Betsuyaku Tomoko
  • Journal Title: Clinical Lung Cancer Volume: 19 Issue: 3 Pages: e349-e358
  • DOI: 10.1016/j.cllc.2018.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative Aqueous Cytokine Levels are Associated With Endothelial Cell Loss After Descemet's Stripping Automated Endothelial Keratoplasty (2018)
  • Author(s): Yazu Hiroyuki、Yamaguchi Takefumi、Aketa Naohiko、Higa Kazunari、Suzuki Terumasa、Yagi-Yaguchi Yukari、Satake Yoshiyuki、Abe Takayuki、Tsubota Kazuo、Shimazaki Jun
  • Journal Title: Investigative Opthalmology & Visual Science Volume: 59 Issue: 2 Pages: 612-612
  • DOI: 10.1167/iovs.17-23049
  • Peer Reviewed / Open Access
• [Journal Article] Value of a Computer-aided Detection System Based on Chest Tomosynthesis Imaging for the Detection of Pulmonary Nodules (2018)
  • Author(s): Yamada Yoshitake、Shiomi Eisuke、Hashimoto Masahiro、Abe Takayuki、Matsusako Masaki、Saida Yukihisa、Ogawa Kenji
  • Journal Title: Radiology Volume: 287 Issue: 1 Pages: 333-339
  • DOI: 10.1148/radiol.2017170405
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Triggering Events on Outcomes of Acute Heart Failure (2018)
  • Author(s): Shiraishi Yasuyuki、Kohsaka Shun、Abe Takayuki、Harada Kazumasa、Miyazaki Tetsuro、Miyamoto Takamichi、Iida Kiyoshi、Tanimoto Shuzou、Yagawa Mayuko、Takei Makoto、Nagatomo Yuji、Hosoda Toru、Yamamoto Takeshi、Nagao Ken、Takayama Morimasa
  • Journal Title: The American Journal of Medicine Volume: 131 Issue: 2 Pages: 156-164.e2
  • DOI: 10.1016/j.amjmed.2017.09.008
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of Indigo naturalis in a Multicenter Randomized Controlled Trial of Patients with Ulcerative Colitis (2017)
  • Author(s): .Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T
  • Journal Title: Gastroenterology Volume: 4 Issue: 4 Pages: 935-947
  • DOI: 10.1053/j.gastro.2017.11.024
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study (2017)
  • Author(s): Yasuda H、Sanui M、Abe T、Shime N、Komuro T、Hatakeyama J、Matsukubo S、Kawano S、Yamamoto H、Andoh K、Seo R、Inoue K、Noda E、Saito N、Nogami S、Okamoto K、Fuke R、Gushima Y、Kobayashi A、Takebayashi T、Lefor AK
  • Journal Title: Critical Care Volume: 21 Issue: 1 Pages: 1-10
  • DOI: 10.1186/s13054-017-1890-z
  • Peer Reviewed / Open Access
• [Journal Article] Association between monoallelic TSHR mutations and congenital hypothyroidism: a statistical approach (2017)
  • Author(s): Abe Kiyomi、Narumi Satoshi、Suwanai Ayuko S.、Adachi Masanori、Muroya Koji、Asakura Yumi、Nagasaki Keisuke、Abe Takayuki、Hasegawa Tomonobu
  • Journal Title: European Journal of Endocrinology Volume: 178 Issue: 2 Pages: 137-144
  • DOI: 10.1530/eje-16-1049
  • Peer Reviewed / Open Access
• [Journal Article] Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry (2017)
  • Author(s): Sawano Mitsuaki、Kohsaka Shun、Abe Takayuki、Inohara Taku、Maekawa Yuichiro、Ueda Ikuko、Sueyoshi Koichiro、Suzuki Masahiro、Noma Shigetaka、Numasawa Yohei、Miyata Hiroaki、Fukuda Keiichi、Smolderen Kim G.、Spertus John A.
  • Journal Title: PLOS ONE Volume: 12 Issue: 8 Pages: 1-15
  • DOI: 10.1371/journal.pone.0182687
  • Peer Reviewed / Open Access
• [Journal Article] The Conditional Survival with Time of Intravesical Recurrence of Upper Tract Urothelial Carcinoma (2017)
  • Author(s): Shigeta Keisuke, Kikuchi Eiji, Hagiwara Masayuki, Ando Toshiyuki, Mizuno Ryuichi, Abe Takayuki, Mikami Shuji, Miyajima Akira, Nakagawa Ken, Oya Mototsugu
  • Journal Title: Journal of Urology Volume: - Issue: 6 Pages: 1278-1285
  • DOI: 10.1016/j.juro.2017.06.073
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: Correlation with perfusion SPECT/CT (2017)
  • Author(s): Tamura Masashi、Yamada Yoshitake、Kawakami Takashi、Kataoka Masaharu、Iwabuchi Yu、Sugiura Hiroaki、Hashimoto Masahiro、Nakahara Tadaki、Okuda Shigeo、Nakatsuka Seishi、Sano Fumiya、Abe Takayuki、Maekawa Yuichiro、Fukuda Keiichi、Jinzaki Masahiro
  • Journal Title: International Journal of Cardiology Volume: 243 Pages: 538-543
  • DOI: 10.1016/j.ijcard.2017.05.006
  • Peer Reviewed / Open Access
• [Journal Article] Difference in the craniocaudal gradient of the maximum pixel value change rate between chronic obstructive pulmonary disease patients and normal subjects using sub-mGy dynamic chest radiography with a flat panel detector system (2017)
  • Author(s): Yamada Yoshitake、Ueyama Masako、Abe Takehiko、Araki Tetsuro、Abe Takayuki、Nishino Mizuki、Jinzaki Masahiro、Hatabu Hiroto、Kudoh Shoji
  • Journal Title: European Journal of Radiology Volume: 92 Pages: 37-44
  • DOI: 10.1016/j.ejrad.2017.04.016
  • Peer Reviewed / Open Access
• [Journal Article] Optimal plateau pressure for patients with acute respiratory distress syndrome: a protocol for a systematic review and meta-analysis with meta-regression (2017)
  • Author(s): Yasuda Hideto、Nishimura Tetsuro、Kamo Tetsuro、Sanui Masamitsu、Nango Eishu、Abe Takayuki、Takebayashi Toru、Lefor Alan Kawarai、Hashimoto Satoru
  • Journal Title: BMJ Open Volume: 7 Issue: 5 Pages: e015091-e015091
  • DOI: 10.1136/bmjopen-2016-015091
  • Peer Reviewed / Open Access
• [Journal Article] Endocytoscopy can be used to assess histological healing in ulcerative colitis patients with clinical and endoscopic remission (2017)
  • Author(s): Yoshihiro Nakazato, Makoto Naganuma, Shinya Sugimoto, Rieko Bessho, Mari Arai, Hiroki Kiyohara, Keiko Ono, Kosaku Nanki, Makoto Mutaguchi, Shinta Mizuno, Taku Kobayashi, Naoki Hosoe, Masayuki Shimoda, Takayuki Abe, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai
  • Journal Title: Endoscopy Volume: 49 Issue: 06 Pages: 560-563
  • DOI: 10.1055/s-0043-106556
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction ― First Pilot Study in Humans ― (2017)
  • Author(s): Katsumata Y, Sano F, Abe T, Tamura T, Fujisawa T, Shiraishi Y, Kohsaka S, Ueda I, Homma K, Suzuki M, Okuda S, Maekawa Y, Kobayashi E, Hori S, Sasaki J, Fukuda K, Sano M.
  • Journal Title: Circulation Journal Volume: 81 Issue: 7 Pages: 940-947
  • DOI: 10.1253/circj.CJ-17-0105
  • NAID: 130006887049
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of aortic arch repair using the endovascular technique, total arch replacement, and staged surgery. (2017)
  • Author(s): Yoshitake A, Okamoto K, Yamazaki M, Kimura N, Hirano A, Iida Y, Abe T, Shimizu H
  • Journal Title: European Journal of Cardio-Thoracic Surgery Volume: - Issue: 6 Pages: 1142-1148
  • DOI: 10.1093/ejcts/ezx028
  • Peer Reviewed
• [Journal Article] Temporal Trends in Renal Function and Birth Weight in Japanese Adolescent Males(1998-2015). (2017)
  • Author(s): Kanda T, Takeda A, Hirose H, Abe T, Urai H, Inokuchi M, Wakino S, Tokumura M, Itoh H, and Kawabe H.
  • Journal Title: Nephrology Dialysis Transplantation Volume: - Issue: 2 Pages: 304-310
  • DOI: 10.1093/ndt/gfw428
  • Peer Reviewed / Open Access
• [Journal Article] Difference in diaphragmatic motion during tidal breathing in a standing position between COPD patients and normal subjects: time-resolved quantitative evaluation using dynamic chest radiography with flat panel detector system ("dynamic X-ray phrenicography"). (2017)
  • Author(s): Yamada Y, Ueyama M, Abe T, Araki T, Abe T, Nishino M, Jinzaki M, Hatabu H, Kudoh S.
  • Journal Title: European Journal of Radiology Volume: 87 Pages: 76-82
  • DOI: 10.1016/j.ejrad.2016.12.014
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of Metabolic Factors Associated with eGFR Decline Over 1 Year in a Japanese Population without CKD (2017)
  • Author(s): Hayashi K, Takayama M, Abe T, Kanda T, Hirose H, Shimizu-Hirota R, Shiomi E, Iwao Y, and Itoh H.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 8 Pages: 863-875
  • DOI: 10.5551/jat.38612
  • NAID: 130005876085
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Time-resolved quantitative analysis of the diaphragms during tidal breathing in a standing position using dynamic chest radiography with a flat panel detector system ("dynamic X-ray phrenicography"): initial experience in 172 volunteers. (2017)
  • Author(s): Yamada Y, Ueyama M, Abe T, Araki T, Abe T, Nishino M, Jinzaki M, Hatabu H, Kudoh S
  • Journal Title: Academic Radiology Volume: Apr; 24(4) Issue: 4 Pages: 393-400
  • DOI: 10.1016/j.acra.2016.11.014
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of Supplementary Cognitive-Behavioral Therapy for Pharmacotherapy-Resistant Depression: A Randomized Controlled Trial. (2017)
  • Author(s): Nakagawa A, Mitsuda D, Sado M, Abe T, Fujisawa D, Kikuchi T, Iwashita S, Mimura M, Ono Y.
  • Journal Title: J Clin Psychiatry. Volume: ー Issue: 8 Pages: 1126-1135
  • DOI: 10.4088/jcp.15m10511
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The learning curve of laparoendoscopic single-site adrenalectomy: an analysis of over 100 cases (2017)
  • Author(s): Fukumoto K., Abe, T. et al.
  • Journal Title: Surgical Endoscopy Volume: 31 Issue: 1 Pages: 170-177
  • DOI: 10.1007/s00464-016-4950-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nivolumab for advanced melanoma: pretreatment prognostic factors and early outcome markers during therapy. (2016)
  • Author(s): Nakamura Y, Kitano S, Takahashi A, Tsutsumida A, Namikawa K, Tanese K, Abe T, Funakoshi T, Yamamoto N, Amagai M, Yamazaki N.
  • Journal Title: Oncotarget Volume: 7 Issue: 47 Pages: 77404-77415
  • DOI: 10.18632/oncotarget.12677
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oncological outcomes of function preserving gastrectomy for early gastric cancer: A multicenter propensity score matched cohort analysis comparing pylorus-preserving gastrectomy versus conventional distal gastrectomy. (2016)
  • Author(s): Aizawa M, Honda M, Hiki N, Kinoshita T, Yabusaki H, Nunobe S, Shibasaki H, Matsuki A, Watanabe M, Abe T.
  • Journal Title: Gastric Cance Volume: - Issue: 4 Pages: 709-717
  • DOI: 10.1007/s10120-016-0644-y
  • NAID: 40021252690
  • Peer Reviewed / Open Access
• [Journal Article] Changes in Right Ventricular Dysfunction after Balloon Pulmonary Angioplasty in Patients with Chronic Thromboembolic Pulmonary Hypertension (2016)
  • Author(s): Tsugu T, Abe, T. et al.
  • Journal Title: American Journal of Cardiology Volume: 118 Issue: 7 Pages: 1081-1087
  • DOI: 10.1016/j.amjcard.2016.07.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of performance of the Omni mode for detecting video capsule endoscopy images: A multicenter randomized controlled trial (2016)
  • Author(s): Hosoe, N., Abe, T. et al.
  • Journal Title: Endoscopy International Open Volume: 4 Issue: 08 Pages: 878-882
  • DOI: 10.1055/s-0042-111389
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of laser in situ keratomileusis on mental health related quality of life. (2016)
  • Author(s): Tounaka-Fujii K, Yuki K, Negishi K, Toda I, Abe T, Kouyama K, Tsubota K.
  • Journal Title: Clinical Ophthalmology Volume: Sep; 10 Pages: 1859-1864
  • DOI: 10.2147/opth.s118545
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of rituximab in Japanese patients with acquired thrombotic thrombocytopenic purpura who are refractory to conventional therapy (2016)
  • Author(s): Miyakawa Y., Abe, T. et al
  • Journal Title: International Journal of Hematology Volume: 104 Issue: 2 Pages: 228-235
  • DOI: 10.1007/s12185-016-2019-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intensive statin therapy stabilizes C-reactive protein, but not chemokine in stable coronary artery disease treated with an everolimus-eluting stent (2016)
  • Author(s): Sukegawa H., Abe, T. et al.
  • Journal Title: Coronary Artery Disease Volume: 27 Issue: 5 Pages: 405-411
  • DOI: 10.1097/mca.0000000000000375
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Long-term outcomes of laparoscopic versus open surgery for clinical stage I gastric cancer: The LOC-1 study. (2016)
  • Author(s): Honda M, Hiki N, Kinoshita T, Yabusaki H, Abe T, Nunobe S, Terada M, Matsuki A, Sunagawa H, Aizawa M, Healy M, Iwasaki M, Furukawa TA.
  • Journal Title: Annals of Surgery Volume: 264(2) Pages: 214-22
  • DOI: 10.21037/tgh.2017.01.06
  • Peer Reviewed / Open Access
• [Journal Article] Safety of Warfarin Therapy in Chronic Hemodialysis Patients: A Prospective Cohort Study. (2016)
  • Author(s): Hayashi M, Abe T, Iwai M, Matsui A, Yoshida T, Sato Y, Kanno Y, Warfarin Study Group.
  • Journal Title: Clinical and Experimental Nephrology Volume: Oct; 20(5) Issue: 5 Pages: 787-794
  • DOI: 10.1007/s10157-015-1205-0
  • Peer Reviewed / Open Access
• [Journal Article] Validation of the Get With The Guideline-Heart Failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide level. (2016)
  • Author(s): Shiraishi Y, Kohsaka S, Abe T, Mizuno A, Goda A, Izumi Y, Yagawa M, Akita K, Sawano M, Inohara T, Takei M, Takashi K, Higuchi S, Yamazoe M, Mahara K, Fukuda K, Yoshikawa T.
  • Journal Title: American Heart Journal Volume: 171 Issue: 1 Pages: 33-39
  • DOI: 10.1016/j.ahj.2015.10.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic factors of Streptococcus pneumoniae sepsis in adults. (2016)
  • Author(s): Hifumi T, Fujishima S, Abe T, Kiriu N, Inoue J, Kato H, Koido Y, Kawakita K, Kuroda Y, Sasaki J, Hori S.
  • Journal Title: The American Journal of Emergency Medicine Volume: 34 Issue: 2 Pages: 202-206
  • DOI: 10.1016/j.ajem.2015.10.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of rituximab in Japanese patients with relapsed chronic immune thrombocytopenia refractory to conventional therapy (2016)
  • Author(s): Miyakawa Y, Katsutani S, Yano T, Nomura S, Nishiwaki K, Tomiyama Y, Higashihara M, Shirasugi Y, Nishikawa M, Ozaki K, Abe T, Kikuchi K, Kanakura Y, Fujimura K, Ikeda Y, Okamoto S.
  • Journal Title: International Journal of Haematology Volume: in press Pages: 1-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reliability analysis of spino-pelvic parameters in adult spinal deformity: A comparison of whole spine and pelvic radiographs. (2016)
  • Author(s): Chen R-Q, Hosogane N, Watanabe K, Funao H, Okada E, Fujita N, Hikata T, Iwanami A, Tsuji T, Ishii K, Abe T, Toyama Y, Nakamura M, Matsumoto M.
  • Journal Title: Spine Volume: 41 Issue: 4 Pages: 320-327
  • DOI: 10.1097/brs.0000000000001208
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort. (2015)
  • Author(s): Hayashi S, Sasaki H, Kimura T, Abe T, Nakamura T, Kitamura Y, Miwa T, Kameyama K, Hirose Y, Yoshida K.
  • Journal Title: Oncotarget Volume: 6 Pages: 15871-15881
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Renal Cyst Pseudoenhancement: Intra-individual Comparison between Virtual Monochromatic Spectral Images and Conventional Polychromatic 120-kVp Images Obtained during the Same CT Examination and Comparisons among Images Reconstructed Using Filtered Back Projection, Adaptive Statistical Iterative Reconstruction and Model-Based Iterative Reconstruction. (2015)
  • Author(s): Yamada Y, Yamada M, Sugisawa K, Akita H, Siomi E, Abe T, Okuda S, Jinzaki M.
  • Journal Title: Medicine Volume: 94 Issue: 15 Pages: 754-754
  • DOI: 10.1097/md.0000000000000754
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk factors for decreased bone mineral density in inflammatory bowel disease: A cross-sectional study. (2015)
  • Author(s): Wada Y, Hisamatsu T, Naganuma M, Matsuoka K, Okamoto S, Inoue N, Yajima T, Kouyama K, Iwao Y, Ogata H, Hibi T, Abe T, Kanai T.
  • Journal Title: Clinical Nutrition Volume: 34 Pages: 1202-1209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Glaucomatous Visual Field Defect Severity and the Prevalence of Motor Vehicle Collisions in Japanese: a hospital/clinic-based cross-sectional study. (2015)
  • Author(s): Ono T, Yuki K, Asaoka R, Kouyama K, Abe T, Tanabe S, Fukagawa K, Uchino M, Shimoyama M, Ozawa Y, Ozeki N, Shiba D, Tsubota K.
  • Journal Title: Journal of Ophthalmology Volume: 1 Pages: 1-8
  • DOI: 10.1155/2015/497067
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Epidural Anesthesia on Growth of escherichia Coli in situ – Roles of lipocalin-2 pathway. (2015)
  • Author(s): Igarashi T, Suzuki T, Mori K, Inoue K, Seki H, Yamada T, Kosugi S, Minamishima S, Katori N, Sano F, Abe T, Morisaki H.
  • Journal Title: Anesthesia & Analgesia Volume: 121 Pages: 81-89
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 臨床研究を計画・実施する際の生物統計学的な留意点 (2018)
  • Author(s): 阿部貴行
  • Organizer: 第26回日本逆流性腎症フォーラム
  • Invited
• [Presentation] 臨床研究における階層データの欠測への補完法の性能評価 (2017)
  • Author(s): 阿部貴行
  • Organizer: 日本計算機統計学会第31回シンポジウム
• [Presentation] 臨床研究推進センターにおける生物統計支援の実際 (2017)
  • Author(s): 阿部貴行，ロバーツレイチェル，佐野文哉，永瀬香，副島研造，佐谷秀行
  • Organizer: ARO協議会第5回学術集会
• [Presentation] 日本産科婦人科学会周産期登録データベースを用いた頸部手術後妊娠の早産期前期破水に関する検討 (2017)
  • Author(s): 宮越敬，板倉敦夫，阿部貴行，近藤英治，田畑務，寺尾泰久，濱田洋実，田中京子，田中守，竹田省
  • Organizer: 第11回日本早産学会学術集会
• [Presentation] Quantitative Assessment of Pupillary Light Reflex for Early Prediction of Outcome After Out-of-hospital Cardiac Arrest: Multicenter Prospective Observational Study (2017)
  • Author(s): Tamura T, Namiki J, Sugawara Y, Sekine K, Yo K, Kanaya T, Yokobori M, Roberts R, Abe T, Yokota Y, Sasaki J
  • Organizer: Resuscitation Science Symposium 2017, American Heart Association
  • Int'l Joint Research
• [Presentation] An evaluation of multiple imputation methods for hierarchical data (2017)
  • Author(s): Abe T and Iwasaki M
  • Organizer: Joint Statistical Meetings
  • Int'l Joint Research
• [Presentation] 質の高い臨床研究を目指して：臨床研究の立案・実施において研究者が悩む生物統計学的事項 (2017)
  • Author(s): 阿部貴行，須藤亜紗実，増渕颯，中川敦夫
  • Organizer: 日本認知療法学会 第17回学術集会
• [Presentation] 治療への期待と治療効果の検討：米国REVAMP データの2次解析 (2017)
  • Author(s): 中川敦夫，須藤亜紗実，増渕颯，阿部貴行
  • Organizer: 日本認知療法学会 第17回学術集会
• [Presentation] 統計科学が切り拓く個別化医療：方法論・実践のフロンティア (2017)
  • Author(s): 阿部貴行
  • Organizer: 科研費基盤S・第8回生物統計ネットワークシンポジウム
  • Place of Presentation: アクロス福岡（福岡県福岡市）
  • Invited
• [Presentation] The effect of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling after the Percutaneous Coronary Intervention for ST-elevated Myocardial Infarction (2017)
  • Author(s): Katsumata Y, Sano F, Abe T, Tamura T, Fujisawa T, Shiraishi Y, Suzuki M, Okuda S, Maekawa Y, Kobayashi E, Hori S, Sasaki J, Fukuda K, Sano M.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
• [Presentation] 生物統計学・臨床研究デザインの教育プログラムの開発 (2016)
  • Author(s): 中川敦夫，新良貴敏公，須藤亜紗実，増渕颯，阿部貴行
  • Organizer: 日本認知療法学会 第16回学術集会
  • Place of Presentation: ナレッジキャピタルコングレコンベンションセンター（大阪府大阪市）
• [Presentation] 大うつ病性障害患者に対するセカンドライン治療における新規抗うつ薬の多施設共同非盲検無作為化可変用量長期投与試験（ACCEPT研究）の安全性に関する中間解析結果 (2016)
  • Author(s): 吉村直記、横井優磨、玉浦明美、波多野賢二、谷将之、西岡玄太郎、阿部貴行、工藤由佳、菊地俊暁、中川敦夫、稲田健、住吉太幹、渡邊衡一郎、諸川由実代、大坪天平、岩波明、三村將、古川壽亮、中込和幸
  • Organizer: 臨床精神神経薬理学会 第26回学術集会
  • Place of Presentation: ホルトホール大分（大分県大分市）
• [Presentation] Evaluation of sensitivity of statistical methods that assume missing at random (2016)
  • Author(s): Abe T, Shiosakai K, Roberts R, Sano F, Iwasaki M
  • Organizer: Joint Statistical Meetings
  • Place of Presentation: Chicago, USA
  • Int'l Joint Research
• [Presentation] 臨床評価におけるデータの蓄積その活用：メタ・アナリシスとその実際 (2016)
  • Author(s): 阿部貴行
  • Organizer: 医学統計研究会・特定主題シンポジウム
  • Place of Presentation: エーザイ株式会社小石川ナレッジセンター（東京都文京区）
• [Presentation] 更年期女性の健康関連QOLと睡眠の評価－リウマチ性疾患患者と健常人との比較－ (2016)
  • Author(s): 宮内清子，藤本薫，阿部貴行，宮地清光
  • Organizer: 第15回更年期と加齢のヘルスケア学会学術集会
  • Place of Presentation: 帝京平成大学中野キャンパス（東京都中野区）
• [Presentation] 更年期女性の健康関連QOLに関連する睡眠活動の実態 (2016)
  • Author(s): 宮内清子，藤本薫，阿部貴行，小川久貴子
  • Organizer: 第45回日本女性心身医学会学術集会
  • Place of Presentation: ピアザ淡海 滋賀県立県民交流センター（滋賀県大津市）
• [Presentation] 更年期にあるシェ―グレン症候群患者の健康関連QOLおよび睡眠の質と疲労の評価-健常人との比較-（第2報） (2016)
  • Author(s): 宮内清子，藤本薫，阿部貴行，武井正美
  • Organizer: 第25回シェーグレン症候群学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
• [Presentation] 中高年女性のシェ―グレン症候群患者における健康関連QOLに関連する疲労・睡眠活動の実態（第1報） (2016)
  • Author(s): 宮内清子，藤本薫，阿部貴行，武井正美
  • Organizer: 第25回シェーグレン症候群学会学術集会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
• [Presentation] Oncological outcome of function preserving gastrectomy for early gastric cancer: A multicenter case-controlled analysis comparing pylorus-preserving gastrectomy versus conventional distal gastrectomy. (2016)
  • Author(s): Aizawa M, Honda M, Hiki N, Kinoshita T, Yabusaki H, Nunobe S, Shibasaki H, Matsuki A, Abe T, Watanabe M, Nashimoto A
  • Organizer: ASCO Annual meeting
  • Place of Presentation: Chicago, USA
  • Int'l Joint Research
• [Presentation] Improvement to antipsychotic treatment at week 2 predicts subsequent treatment response in behavioral and psychological symptoms with dementia: Analysis of the CATIE-AD data. (2016)
  • Author(s): Yoshida K, Roberts R, Abe T, Suzuki T, Lebowitz B, Tsunoda K, Endo A, Ohtani A, Mimura M, Uchida H
  • Organizer: 30th Collegium Internationale Neuro-Psychopharmacologium
  • Place of Presentation: Seoul,Korea
  • Int'l Joint Research
• [Presentation] Investigator-initiated phase 2 trial of rituximab for adult Japanese patients with acquired thrombotic thrombocytopenic purpura those are refractory to previous treatments and/or with high titer of ADAMTS13 inhibitor. (2015)
  • Author(s): Miyakawa Y, Imada K, Ichinohe T, Yamane Y, Nishio K, Abe T, Fujimura Y, Matsumoto M, Okamoto S
  • Organizer: American Society of Hematology 57th Annual Meeting
  • Place of Presentation: Orland (U.S.A.)
  • Year and Date: 2015-12-08
  • Int'l Joint Research
• [Presentation] 特別セッション「医療機関に所属する統計家の現状と課題」：医学部・大学病院における統計家の役割 －海外との比較－． (2015)
  • Author(s): 阿部貴行
  • Organizer: 日本計算機統計学会第29回シンポジウム
  • Place of Presentation: まなぼっと幣舞（北海道釧路市）
  • Year and Date: 2015-11-27
• [Presentation] Investigator-initiated clinical trial of rituximab for thrombotic thrombocyt openic purpura (2015)
  • Author(s): Miyakawa Y, Imada K, Ichinohe T, Yamane Y, Nishio K, Abe T, Fujimura Y, Matsumoto M, Okamoto S
  • Organizer: 第77回日本血液学会総会
  • Place of Presentation: 石川県立音楽堂（石川県金沢市）
  • Year and Date: 2015-10-16
• [Presentation] Usefulness of new Algotithm-implemented reading software for small-bowel capsule endoscopy (CE). (2015)
  • Author(s): Ohmiya N, Watanabe K, Miyazaki T, Shimatani M, Wakamatsu T, Okazaki K, Esaki M, Matsumoto T, Abe T, Hosoe N, Kanai T, Ohtsuka K, Watanabe M, Ikeda K, Tajiri H, Nakamura M, Goto H, Tsujikawa T, Ogata H:
  • Organizer: UEG Week
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] Imputation models for longitudinal zero-inflated count data with dropouts. (2015)
  • Author(s): Abe T, Sato Y and Iwasaki
  • Organizer: International Society of Clinical Biostatistics
  • Place of Presentation: Utrechit (The Netherlands)
  • Year and Date: 2015-08-24
  • Int'l Joint Research
• [Presentation] Multiple imputation for longitudinal count data with dropouts – A methodological evaluation. (2015)
  • Author(s): Abe T, Shiosakai K, Sano F, Roberts R, Sato Y, Iwasaki M
  • Organizer: Joint Statistical Meetings
  • Place of Presentation: Seattle (U.S.A)
  • Year and Date: 2015-08-08
  • Int'l Joint Research
• [Presentation] ワークショップ 精神療法の臨床研究計画立案から実施まで：これから実証研究を始めたい方にむけて (サンプルサイズを考えよう-検出力と実施可能性のバランスをどうする). (2015)
  • Author(s): 阿部貴行
  • Organizer: 第12回日本うつ病学会総会・第15回日本認知療法学会
  • Place of Presentation: NSスカイカンファレンス（東京都新宿区）
  • Year and Date: 2015-07-19
• [Book] 欠測データの統計解析 (2016)
  • Author(s): 阿部貴行
  • Total Pages: 190
  • Publisher: 朝倉書店
• [Funded Workshop] 科研費国際シンポジウム：臨床試験における生物統計家の貢献 (2016)
  • Place of Presentation: 慶應義塾大学医学部信濃町キャンパス（東京都新宿区）