| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The aim of this study was to clarify the association between monocarboxylate transporter (MCT) 1, 4 and tumor cell growth and invasion and to identify the selective inhibitor of MCT1 or 4. This study summarizes our findings:1)At first, MCT1 or 4 is a pH-dependent transporter, is functional expressed in MCF7 or MDA-MB231 cells such as breast cancer cells. 2)MCT1 or 4 knockdown induces the reduction of these cells viability and migration compared with negative control-treated cells. 3)Fibrates and bindarit exhibit selective inhibitory effects against MCT4 compared with MCT1. These results suggest that MCT1 and 4 are associated with tumor cell viability and migration.
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