lectin-derived from Maackia amurensis as a novel therapeutic option for treatment of skin diseases.

• Project/Area Number: 15K08582
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Asahikawa Medical College
• Principal Investigator: Honma Masaru 旭川医科大学, 医学部, 准教授 (50344578)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: podoplanin / 乾癬 / エンジュ / ポドプラニン / イミキモド / レクチン / エンジュレクチン / IL22 / IL24 / サイトカイン / 3次元培養表皮

Outline of Final Research Achievements

MASL, a lectin-derived from Maackia amurensis, can work as a therapeutic agent on psoriasis via regulation of podoplanin-expression and the function. The precise functional mechanism has not been fully elucidated. However, results acquired in this study and safety of oral MASL administration to mice in previous reports suggest the possibility of MASL as a novel therapeutic option for the treatment of psoriasis.

Research Products

• [Journal Article] RIPK1 downregulation in keratinocyte enhances TRAIL signaling in psoriasis. (2018)
  • Author(s): Saito N, Honma M, Shibuya T, Iinuma S, Igawa S, Kishibe M, Ishida-Yamamoto A.
  • Journal Title: J Dermatol Sci. Volume: in press Issue: 1 Pages: 79-86
  • DOI: 10.1016/j.jdermsci.2018.04.007
  • Peer Reviewed
• [Journal Article] Alteration of serum thymus and activation-regulated chemokine level during biologic therapy for psoriasis: Possibility as a marker reflecting favorable response to anti-interleukin-17A agents. (2018)
  • Author(s): Shibuya T, Honma M, Iinuma S, Iwasaki T, Takahashi H, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: in press Issue: 6 Pages: 710-714
  • DOI: 10.1111/1346-8138.14308
  • NAID: 120006648800
  • Peer Reviewed
• [Journal Article] Persistent pruritus in psoriatic patients during administration of biologics. (2018)
  • Author(s): Shibuya T, Honma M, Iinuma S, Iwasaki T, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: in press Issue: 8
  • DOI: 10.1111/1346-8138.14284
• [Journal Article] Genetic background and therapeutic response in generalized pustular psoriasis patients treated with granulocyte and monocyte adsorption apheresis. (2018)
  • Author(s): Ohnishi H, Kadowaki T, Mizutani Y, Nishida E, Tobita R, Abe N, Yamaguchi Y, Eto H, Honma M, Kanekura T, Okubo Y, Seishima M, Fukao T, Ikeda S.
  • Journal Title: Eur J Dermatol. Volume: 28 Pages: 108-111
  • Peer Reviewed
• [Journal Article] Psoriasis verrucosa complicated by generalized pustular psoriasis. (2018)
  • Author(s): Iinuma S, Matsuo R, Fujii M, Honma M, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: 45 Issue: 3
  • DOI: 10.1111/1346-8138.14185
  • Peer Reviewed
• [Journal Article] Therapeutic depletion of myeloid lineage leukocytes by adsorptive apheresis for psoriatic arthritis: Efficacy of a non-drug intervention for patients refractory to pharmacologics. (2017)
  • Author(s): Kanekura T, Seishima M, Honma M, Etou T, Eto H, Okuma K, Okubo Y, Yamaguchi Y, Kambara T, Mabuchi T, Suga Y, Morita A, Yamanishi K, Tsuruta D, Itoh K, Yamaji K, Ikeda S.
  • Journal Title: J Dermatol. Volume: 44 Issue: 12 Pages: 1353-1359
  • DOI: 10.1111/1346-8138.13975
  • Peer Reviewed
• [Journal Article] Prevalence of coronary artery calcification in Japanese patients with psoriasis: A close correlation with bilateral diagonal earlobe creases. (2017)
  • Author(s): Honma M, Shibuya T, Iwasaki T, Iinuma S, Takahashi N, Kishibe M, Minami-Hori M, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: 44 Issue: 10 Pages: 1122-1128
  • DOI: 10.1111/1346-8138.13895
  • Peer Reviewed
• [Journal Article] Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through protease-activated receptor 2-independent mechanism. (2017)
  • Author(s): Iinuma S, Kishibe M, Saito N, Igawa S,Honma M, Bando Y, Yoshida S,Ishida-Yamamoto A.
  • Journal Title: Exp Dermatol. Volume: 26(3) Issue: 3 Pages: 289-291
  • DOI: 10.1111/exd.13204
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Close correlation of bone mineral density and body mass index in Japanese psoriasis patients. (2017)
  • Author(s): Honma M, Shibuya T, Iinuma S, Kishibe M, Takahashi H, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: 44 Issue: 3
  • DOI: 10.1111/1346-8138.13470
  • Peer Reviewed
• [Journal Article] Aberrant LIM-kinase 1 expression in hyperproliferative psoriatic epidermis. (2017)
  • Author(s): Honma M, Shibuya T, Fujii M, Iinuma S, Ishida-Yamamoto A.
  • Journal Title: J Dermatol. Volume: 44 Issue: 1 Pages: 91-92
  • DOI: 10.1111/1346-8138.13456
  • Peer Reviewed
• [Journal Article] Aberrant LIM-kinase 1-expression in hyperproliferative psoriatic epidermis (2016)
  • Author(s): Honma M, Shibuya T, Fujii M, Iinuma S, Ishida-Yamamoto A
  • Journal Title: The Journal of Dermatology Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Aberrant LIM-kinase 1-expression in hyperproliferative psoriatic epidermis. (2016)
  • Author(s): Honma M, Shibuya T, Iinuma S, Kishibe M, Takahashi H, Ishida-Yamamoto A.
  • Journal Title: The Journal of Dermatology Volume: in press
  • Peer Reviewed
• [Journal Article] Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open label multi-center Japanese study. (2016)
  • Author(s): Imafuku S, Honma M, Okubo Y, Komine M, Ohtsuki M, Morita A, Seko N, Kawashima N, Ito S, Shima T, Nakagawa H.
  • Journal Title: The Journal of Dermatology Volume: in press Issue: 9 Pages: 1011-1017
  • DOI: 10.1111/1346-8138.13306
  • Peer Reviewed
• [Journal Article] Corneodesmosin gene deletion is prevalent in Japanese patients with peeling skin disease: identification of 2 new cases. (2016)
  • Author(s): Teye K, Suga Y, Numata S, Ishii N, Krol RP, Ohata C, Matsuda M, Honma M, Ishida-Yamamoto A, Hamada T, Hashimoto T.
  • Journal Title: Journal of Dermatological Science Volume: 82 Issue: 2 Pages: 134-137
  • DOI: 10.1016/j.jdermsci.2016.01.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A novel postzygotic KRAS mutation in a Japanese case of epidermal nevus syndrome presenting with two distinct clinical features: keratinocytic epidermal nevi and sebaceous nevi. (2016)
  • Author(s): Igawa S, Honma M, Minami-Hori M, Tsuchida E, Iizuka H, Ishida-Yamamoto A.
  • Journal Title: The Journal of Dermatology Volume: 43 Issue: 1 Pages: 103-104
  • DOI: 10.1111/1346-8138.13153
  • NAID: 120005954153
  • Peer Reviewed
• [Journal Article] Serum carcinoembryonic antigen (CEA) as a clinical marker in idiopathic pure sudomotor failure: a close correlation between serum CEA level and disease activity. (2016)
  • Author(s): Honma M, Iinuma S, Kanno K, Minami-Hori M, Komatsu S, Iizuka H, Ishida-Yamamoto A.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: in press Issue: 8 Pages: 1379-1383
  • DOI: 10.1111/jdv.13390
  • Peer Reviewed
• [Journal Article] Subcutaneous benign fibrous histiocytoma of upper eyelid: a review of the histopathological database at a single faculty in Japan. (2015)
  • Author(s): Honma M, Minami-Hori M, Komatsu S, Hashimoto M, Ishida-Yamamoto A.
  • Journal Title: Int J Clin Dermatol & Res. Volume: 3 Pages: 65-67
  • DOI: 10.19070/2332-2977-1500017
  • Peer Reviewed
• [Journal Article] Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis. (2015)
  • Author(s): Iinuma S, Kishibe M, Saito N, Igawa S, Honma M, Takahashi H, Bando Y, Yoshida s, Iizuka H, Ishida-Yamamoto A.
  • Journal Title: Exp Dermatol Volume: 24 Issue: 11 Pages: 887-889
  • DOI: 10.1111/exd.12794
  • Peer Reviewed
• [Journal Article] Accelerated nail elongation speed in psoriasis patients. (2015)
  • Author(s): Honma M, Iinuma S, Takahashi H, Iizuka H, Ishida-Yamamoto A.
  • Journal Title: The Journal of Dermatology Volume: 42 Issue: 9 Pages: 910-911
  • DOI: 10.1111/1346-8138.12990
  • Peer Reviewed
• [Presentation] Serum carcinoembryonic antigen (CEA) as a clinical marker in idiopathic pure sudomotor failure: a close correlation between serum CEA level and disease activity (2016)
  • Author(s): Honma M, Iinuma S, Kishibe M, Minami-Hori M, Ishida-Yamamoto A.
  • Organizer: 日本研究皮膚科学会第40回年次学術大会・総会
  • Place of Presentation: 岡山市
  • Year and Date: 2016-12-11
• [Presentation] Maackia amurensis seed lectin can suppress IL-22-induced hyperproliferative reconstituted epidermis (2016)
  • Author(s): Masaru Honma, Takashi Shibuya, Mizue Fujii, Shin Iinuma, Nao Saito, Akemi Ishida-Yamamto
  • Organizer: 日本研究皮膚科学会
  • Place of Presentation: 仙台市
  • Year and Date: 2016-12-09
• [Presentation] 後天性特発性全身性無汗症における臨床マーカーとしての血清CEA値の検討 (2016)
  • Author(s): 本間 大、飯沼 晋、菅野恭子、堀 仁子、小松成綱、山本明美
  • Organizer: 第79回日本皮膚科学会東京支部東部支部合同学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2016-02-20
• [Presentation] 乾癬患者における爪甲伸長速度の検討 (2015)
  • Author(s): 本間 大、澁谷貴史、飯沼 晋、高橋英俊、飯塚 一、山本明美.
  • Organizer: 第30回日本乾癬学会学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-09-04