lectin-derived from Maackia amurensis as a novel therapeutic option for treatment of skin diseases.
Project/Area Number |
15K08582
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied pharmacology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
Honma Masaru 旭川医科大学, 医学部, 准教授 (50344578)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | podoplanin / 乾癬 / エンジュ / ポドプラニン / イミキモド / レクチン / エンジュレクチン / IL22 / IL24 / サイトカイン / 3次元培養表皮 |
Outline of Final Research Achievements |
MASL, a lectin-derived from Maackia amurensis, can work as a therapeutic agent on psoriasis via regulation of podoplanin-expression and the function. The precise functional mechanism has not been fully elucidated. However, results acquired in this study and safety of oral MASL administration to mice in previous reports suggest the possibility of MASL as a novel therapeutic option for the treatment of psoriasis.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Genetic background and therapeutic response in generalized pustular psoriasis patients treated with granulocyte and monocyte adsorption apheresis.2018
Author(s)
Ohnishi H, Kadowaki T, Mizutani Y, Nishida E, Tobita R, Abe N, Yamaguchi Y, Eto H, Honma M, Kanekura T, Okubo Y, Seishima M, Fukao T, Ikeda S.
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Journal Title
Eur J Dermatol.
Volume: 28
Pages: 108-111
Related Report
Peer Reviewed
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[Journal Article] Therapeutic depletion of myeloid lineage leukocytes by adsorptive apheresis for psoriatic arthritis: Efficacy of a non-drug intervention for patients refractory to pharmacologics.2017
Author(s)
Kanekura T, Seishima M, Honma M, Etou T, Eto H, Okuma K, Okubo Y, Yamaguchi Y, Kambara T, Mabuchi T, Suga Y, Morita A, Yamanishi K, Tsuruta D, Itoh K, Yamaji K, Ikeda S.
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Journal Title
J Dermatol.
Volume: 44
Issue: 12
Pages: 1353-1359
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open label multi-center Japanese study.2016
Author(s)
Imafuku S, Honma M, Okubo Y, Komine M, Ohtsuki M, Morita A, Seko N, Kawashima N, Ito S, Shima T, Nakagawa H.
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Journal Title
The Journal of Dermatology
Volume: in press
Issue: 9
Pages: 1011-1017
DOI
Related Report
Peer Reviewed
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[Journal Article] Corneodesmosin gene deletion is prevalent in Japanese patients with peeling skin disease: identification of 2 new cases.2016
Author(s)
Teye K, Suga Y, Numata S, Ishii N, Krol RP, Ohata C, Matsuda M, Honma M, Ishida-Yamamoto A, Hamada T, Hashimoto T.
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Journal Title
Journal of Dermatological Science
Volume: 82
Issue: 2
Pages: 134-137
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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