Cisplatin conjugated gelatin hydrogel in a sustained release formulation for intraabdominal chemotherapy for peritoneal carcinomatosis

Research Project

Project/Area Number	15K08586
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied pharmacology
Research Institution	Kyoto University
Principal Investigator	Tsunoda Shigeru 京都大学, 医学研究科, 講師 (60597300)
Co-Investigator(Kenkyū-buntansha)	坂井義治京都大学, 医学研究科, 教授 (60273455)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	腹腔内化学療法 / 徐放化 / 胃癌 / 癌性腹膜炎 / ドラッグデリバリー
Outline of Final Research Achievements	In this study, we have reformed our previous cisplatin sustained-release formula (gelatin microspheres incorporating CDDP: GM-CDDP) and we have developed novel formulation (gelatin hydrogel granules with incorporated cisplatin; GHG-CDDP) without using organic sorbent and which accomplished complete sustained release with only <2% initial burst. By intraperitoneal injection, good therapeutic effect was achieved with less systemic adverse effect such as body weight loss or renal toxicity in murine peritoneal carcinomatosis model.

Report

(4 results)