Cisplatin conjugated gelatin hydrogel in a sustained release formulation for intraabdominal chemotherapy for peritoneal carcinomatosis
| Project/Area Number |
15K08586
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
坂井 義治 京都大学, 医学研究科, 教授 (60273455)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 腹腔内化学療法 / 徐放化 / 胃癌 / 癌性腹膜炎 / ドラッグデリバリー |
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| Outline of Final Research Achievements |
In this study, we have reformed our previous cisplatin sustained-release formula (gelatin microspheres incorporating CDDP: GM-CDDP) and we have developed novel formulation (gelatin hydrogel granules with incorporated cisplatin; GHG-CDDP) without using organic sorbent and which accomplished complete sustained release with only <2% initial burst. By intraperitoneal injection, good therapeutic effect was achieved with less systemic adverse effect such as body weight loss or renal toxicity in murine peritoneal carcinomatosis model.
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Report
(4 results)
Research Products
(4 results)
