Exploratory research of new drugs for age-related macular degeneration decreasing treatment cost and invasiveness

Research Project

Project/Area Number	15K08587
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied pharmacology
Research Institution	Kyoto University
Principal Investigator	Kohno Masayuki 京都大学, 医学研究科, 特定講師 (00437203)
Research Collaborator	HORIBE Tomohisa KAWAKAMI koji MUSASHI Kunihiro OKUNO Yasushi IKEDA Hanako SEHARA Atsuko IIDA Atsuo
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	網膜変性 / フィトケミカル / 血管新生 / 加齢黄斑変性 / 低侵襲化
Outline of Final Research Achievements	We studied antioxidant and cell-protective effect of fit-chemicals including brown rice in renal degeneration. In vitro study, promising candidates could inhibit H2O2-induced oxidative stress. Promising drugs were given orally by water bottle to sodium iodate-induced renal degeneration mice. The retina was examined by electroretinography (ERG) and optical coherence tomography (OCT) in living mice. Ferulic acid and sinapic acid including brown rice could protect retinal pigment epithelium from sodium iodate-induced degeneration. New angiogenesis inhibitors were found in candidate low-molecular compounds selected by chemical genomics-based virtual screening (CGBVS).
Academic Significance and Societal Importance of the Research Achievements	近年の加齢に伴う網膜変性等の顕著な増加は食の欧米化が関係しているという仮説に基づいて、玄米等穀類に含まれるフィトケミカルの経口摂取による網膜変性抑制/予防の可能性を評価した。網膜変性マウスモデルにおいて、フェルラ酸等のフィトケミカルの変性疾患予防/抑制効果等を示すことができた。これらが高齢者等の網膜系疾患に対するサプリメントもしくは医薬品として、実際の医療に適用できれば高騰している医療費削減の一助となりうる。

Report

(4 results)

2017 Annual Research Report Final Research Report ( PDF )
2016 Research-status Report
2015 Research-status Report

Research Products
(1 results)

All Patent(Industrial Property Rights) (1 results)

[Patent(Industrial Property Rights)] 網膜変性疾患抑制剤2017
- Inventor(s)
  川上浩司、河野雅之、武蔵国弘
- Industrial Property Rights Holder
  京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-237268
- Filing Date
  2017
- Related Report
  2017 Annual Research Report