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Quantitative analysis of the factors that confer inter-individual variation of the extent of beverage-drug interactions

Research Project

Project/Area Number 15K08596
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionKeio University

Principal Investigator

Hisakazu OHTANI  慶應義塾大学, 薬学部(芝共立), 教授 (70262029)

Co-Investigator(Renkei-kenkyūsha) AKIYOSHI Takeshi  慶應義塾大学, 薬学部, 専任講師 (50399143)
IMAOKA Ayuko  慶應義塾大学, 薬学部, 助教 (10710957)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords薬物相互作用 / 薬物代謝酵素 / 薬物トランスポータ / 代謝阻害 / 遺伝子多型 / 飲食物 / 代謝酵素 / トランスポータ
Outline of Final Research Achievements

The influences of genetic variation of CYP3A4 on the inhibitory kinetics of its inhibitors varied among the inhibitors and affected by the probe substrate used. The inhibitor manners (patterns) of metabolic inhibitors contained in fruit juice are different among CYP isoforms, i.e. CYP3A4, 2C9 and 2C19. The research should be focused upon the mode of inhibition that is clinically most relevant.
Using newly developed cell lines stably expressing a transporter OATP1A2 or OATP2B1, some unidentified inhibitory ingredient(s) for these transporters are considered to be contained in some fractions of grapefruit juice.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin2017

    • Author(s)
      Ishikawa Yuko、Akiyoshi Takeshi、Imaoka Ayuko、Ohtani Hisakazu
    • Journal Title

      Biopharmaceutics & Drug Disposition

      Volume: 38 Issue: 7 Pages: 420-425

    • DOI

      10.1002/bdd.2078

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] CYP2C19 代謝活性に対する天然果実成分の阻害様式及びキネティクスの評価2018

    • Author(s)
      関 博行, 秋好 健志, 今岡 鮎子, 大谷 壽一.
    • Organizer
      日本薬学会第 138 年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] グレープフルーツジュース成分および resveratrol の CYP2C9 阻害特性解析2017

    • Author(s)
      内山 茉里夏, 秋好 健志, 今岡 鮎子, 大谷 壽一
    • Organizer
      日本薬学会第 137 年会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] CYP3A4 genetic variants に対する各種アゾール系抗真菌薬の阻害特性の比較2017

    • Author(s)
      川村 豪, 今岡 鮎子, 秋好 健志, 日比野 英幸, 荒木 拓也, 宮崎 光江, F.P Guengerich, 中村 克徳, 中村 智徳, 山本 康次郎, 大谷 壽一
    • Organizer
      日本薬学会第 137 年会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] CYP3A4 各変異型分子種の代謝活性に対する MBI 阻害剤の阻害強度の体系的比較2016

    • Author(s)
      内藤里菜、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県・横浜市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] CYP3A4 遺伝的 variant に対する競合阻害剤の阻害特性の体系的比較2015

    • Author(s)
      綾 華奈子、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、 F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
    • Organizer
      第53回日本薬学会関東支部大会
    • Place of Presentation
      日本大学薬学部 (千葉県・船橋市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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