ANALYSIS OF THERAPEUTIC TARGET MOLECULES FOR SUSTAINED ATRIAL FIBRILLATION CAUSED BY CHRONIC VOLUME OVERLOAD
| Project/Area Number |
15K08598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
相本 恵美 東邦大学, 薬学部, 助教 (20756358)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 心房細動 / 心房拡大 / 慢性容量負荷 / アルドステロン / TRPC3チャネル / 動静脈瘻 |
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| Outline of Final Research Achievements |
The duration of atrial fibrillation in rats with abdominal aortocaval fistula was prolonged by chronic administration of aldosterone in a dose-dependent manner, which was effectively suppressed by an inhibitor of transient receptor potential canonical 3 (TRPC3) channels. The results may reveal that atrial remodelings caused by aldosterone administration in addition to chronic volume overload are closely associated with activation of TRPC3 channels, and it is expected that inhibitors of this channel will be applied for the therapy of atrial fibrillation.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs2018
Author(s)
Ando K, Takahara A, Nakamura Y, Wada T, Chiba K, Goto A, Lubna NJ, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Hoshiai K, Akie Y, Naito AT, Sugiyama A
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Journal Title
Journal of pharmacological sciences
Volume: 136
Issue: 2
Pages: 86-92
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impacts of Surgically Performed Renal Denervation on the Cardiovascular and Electrophysiological Variables in the Chronic Atrioventricular Block Dogs – Comparison With Those of Amiodarone Treatment –2016
Author(s)
Wada T, Ohara H, Nakamura Y, Yokoyama H, Cao X, Izumi-Nakaseko H, Ando K, Murakoshi N, Sato A, Aonuma K, Takahara A, Nakazato Y, Sugiyama A.
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Journal Title
Circulation Journal
Volume: 80
Issue: 7
Pages: 1556-1563
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Manifestation of automaticity in the pulmonary vein myocardium of rats with abdominal aorto-venocaval shunt.2015
Author(s)
Shogo Hamaguchi, Yayoi Tsuneoka, Ayumi Tanaka, Masahiko Irie, Masato Tsuruta, Takahiro Nakayama, Iyuki Namekata, Mizuki Nada, Megumi Aimoto, Akira Takahara, Hikaru Tanaka.
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Journal Title
J. Pharmacol. Sci.
Volume: 128
Issue: 4
Pages: 212-215
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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