| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The duration of atrial fibrillation in rats with abdominal aortocaval fistula was prolonged by chronic administration of aldosterone in a dose-dependent manner, which was effectively suppressed by an inhibitor of transient receptor potential canonical 3 (TRPC3) channels. The results may reveal that atrial remodelings caused by aldosterone administration in addition to chronic volume overload are closely associated with activation of TRPC3 channels, and it is expected that inhibitors of this channel will be applied for the therapy of atrial fibrillation.
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