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Roles of AGEs as exacerbation factor in pathogenesis of tissue remodeling and the development of novel targeted therapy

Research Project

Project/Area Number 15K08605
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionShujitsu University

Principal Investigator

MORI Shuji  就実大学, 薬学部, 教授 (50220009)

Co-Investigator(Kenkyū-buntansha) 豊村 隆男  就実大学, 薬学部, 講師 (40425137)
渡邊 政博  就実大学, 薬学部, 助教 (10758246)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords炎症 / 組織リモデリング / サイトカイン / 分子標的
Outline of Final Research Achievements

We screened the binding factor which can interact with HMGB1 by ProtoArray analysis, and studied the pathophysiological roles of its interaction. As the result, we found that TWEAK can interact with HMGB1 with high affinity. TWEAK induced the enhancement of IL-8 mRNA expression in endothelial cells. AGEs specifically bind to TWEAK, and inhibited some inflammatory activities including TWEAK-induced IL-8 mRNA expression. These findings indicated the importance of TWEAK-AGEs interaction as novel therapeutic target molecule in the inflammatory diseases.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (9 results)

  • [Journal Article] Phagocytosis of Advanced Glycation End Products (AGEs) in Macrophages Induces Cell Apoptosis.2017

    • Author(s)
      Gao Y, Wake H, Morioka Y, Liu K, Teshigawara K, Shibuya M, Zhou J, Mori S, Takahashi H, Nishibori M.
    • Journal Title

      Oxid Med Cell Longev.

      Volume: 2017:8419035 Issue: 1 Pages: 8419035-8419035

    • DOI

      10.1155/2017/8419035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets.2017

    • Author(s)
      Morioka Y, Teshigawara K, Tomono Y, Wang D, Izushi Y, Wake H, Liu K, Takahashi HK, Mori S, Nishibori M.
    • Journal Title

      J Pharmacol Sci.

      Volume: 134(4) Issue: 4 Pages: 218-224

    • DOI

      10.1016/j.jphs.2017.07.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Advanced glycation end products attenuate the function of tumor necrosis factor-like weak inducer of apoptosis to regulate the inflammatory response2017

    • Author(s)
      Watanabe M, Toyomura T, Wake H, Liu K, Teshigawara K, Takahashi H, Nishibori M, Mori S
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 印刷中 Issue: 1-2 Pages: 153-162

    • DOI

      10.1007/s11010-017-3045-6

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] AGEs-RAGE間相互作用に影響を与える生理活性因子の同定と性状2017

    • Author(s)
      森 秀治 他
    • Organizer
      ConBio2017(第90回日本分子生物学会,第90回日本生化学会合同大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 破骨細胞分化抑制因子としてのSHIL004の機能解析2017

    • Author(s)
      豊村隆男 他
    • Organizer
      ConBio2017(第90回日本分子生物学会,第90回日本生化学会合同大会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゲノム編集によるAGEsの作用メカニズム解析プラットフォームの構築2017

    • Author(s)
      渡邊政博 他
    • Organizer
      第132回日本薬理学会近畿部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 非炎症分子SHILsはサイトカインとともに破骨細胞分化を調節する2016

    • Author(s)
      豊村隆男 他
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Research-status Report
  • [Presentation] AGEsによるTNF関連分子の機能変化2016

    • Author(s)
      渡邊政博 他
    • Organizer
      第130回日本薬理学会近畿部会
    • Place of Presentation
      京都大学百周年時計台記念館(京都市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
  • [Presentation] AGEs親和性因子としての60S ribosomal proteinの単離2016

    • Author(s)
      森 秀治 他
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 破骨細胞分化ステージ特異的な非炎症性物質SHIL001及びSHIL002の効果2015

    • Author(s)
      豊村隆男
    • Organizer
      第38回日本分子生物学会・第88回日本生化学会合同大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] AGEs-RAGE結合増大活性を示すHMGB1結合因子の探索2015

    • Author(s)
      森 秀治
    • Organizer
      第38回日本分子生物学会・第88回日本生化学会合同大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] HMGB1と相互作用するサイトカインに対するAGEsの影響2015

    • Author(s)
      渡邊政博
    • Organizer
      第38回日本分子生物学会・第88回日本生化学会合同大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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