| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The 2-arachidonoylglycerol (2-AG) is an endocannabinoid that binds to cannabinoid receptor. We previously reported that hypothalamic 2-AG was increased after conditioning to the rewarding properties of HFD. In this study, we investigated the effects of HFD on the 2-AG levels and the biochemical levels. And, we also studied whether observed effects could be reversed upon removal of the HFD. As a results, HFD intake led to hyperlipidemia and liver dysfunction. And these phenotypes reversed upon removal of the HFD. While, the increment of hypothalamic 2-AG level after HFD intake did not reverse upon removal of the HFD.
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