Elucidation of mechanism on neuronal cell death and development of hemodiagnosis in ischemic stroke

• Project/Area Number: 15K08615
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Hiroshima University
• Principal Investigator: Hosomi Naohisa 広島大学, 医歯薬保健学研究科(医), 准教授 (70363190)
• Co-Investigator(Kenkyū-buntansha): 高橋 哲也 広島大学, 病院(医), 講師 (00435942) ; 辻田 麻紀 名古屋市立大学, 大学院医学研究科, 講師 (10253262) ; 松本 昌泰 広島大学, 医歯薬保健学研究院(医), 教授 (20192346) ; 神沼 修 山梨大学, 総合研究部, 准教授 (80342921) ; 田中 茂 広島大学, 医歯薬保健学研究科(医), 講師 (20512651)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脳卒中 / バイオマーカー / 脳梗塞

Outline of Final Research Achievements

We have tried to evaluate associations of transmembrane protein 95 on neuronal physiological function and ischemic neuronal cell death for elucidating a part of mechanism of neuronal cell death in ischemic stroke, And, we aimed to develop a hemodiagnosis in acute ischemic stroke with developing quantitive assay of transmembrane protein 95. We have created several antibodies against transmembrane protein 95 to construct ELISA system. Specificity and sensitivity of those antibodies were still on analysis.

Research Products

• [Journal Article] Controlling Nutritional Status score for predicting 3-month functional outcome in acute ischemic stroke. (2018)
  • Author(s): Naito H, Nezu T, Hosomi N, Aoki S, Kinoshita N, Kuga J, Shimomura R, Araki M, Ueno H, Ochi K, Maruyama H.
  • Journal Title: Nutrition. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Charged Residues in the C-Terminal Domain of Apolipoprotein A-I Modulate Oligomerization (2018)
  • Author(s): Fuentes Lukas A.、Beck Wendy H. J.、Tsujita Maki、Weers Paul M. M.
  • Journal Title: Biochemistry Volume: 57 Issue: 15 Pages: 2200-2210
  • DOI: 10.1021/acs.biochem.7b01052
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Ischemic Stroke Mortality Is More Strongly Associated with Anemia on Admission Than with Underweight Status (2017)
  • Author(s): Kubo Satoshi、Hosomi Naohisa、Hara Naoyuki、Neshige Shuichiro、Himeno Takahiro、Takeshima Shinichi、Takamatsu Kazuhiro、Shimoe Yutaka、Ota Taisei、Maruyama Hirofumi、Ohtsuki Toshiho、Kuriyama Masaru、Matsumoto Masayasu
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 26 Issue: 6 Pages: 1369-1374
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.02.016
  • Peer Reviewed
• [Journal Article] Various meteorological conditions exhibit both immediate and delayed influences on the risk of stroke events: The HEWS stroke study (2017)
  • Author(s): Mukai Tomoya、Hosomi Naohisa、Tsunematsu Miwako、Sueda Yoshimasa、Shimoe Yutaka、Ohshita Tomohiko、Torii Tsuyoshi、Aoki Shiro、Nezu Tomohisa、Maruyama Hirofumi、Kakehashi Masayuki、Matsumoto Masayasu、on behalf of the Hiroshima ‘Emergency and Weather’ Study-stroke collaborators
  • Journal Title: PLOS ONE Volume: 12 Issue: 6 Pages: e0178223-e0178223
  • DOI: 10.1371/journal.pone.0178223
  • Peer Reviewed / Open Access
• [Journal Article] Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDL Biogenesis in Hepatocytes (2017)
  • Author(s): Maki Tsujita, Mohammad Anwar Hossain, Rui Lu, Tomoe Tsuboi, Kuniko Okumura-Noji and Shinji Yokoyama
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 11 Pages: 1132-1149
  • DOI: 10.5551/jat.39156
  • NAID: 130006191604
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The multidisciplinary swallowing team approach decreases pneumonia onset in acute stroke patients. (2016)
  • Author(s): Shiro Aoki, Naohisa Hosomi, Junko Hirayama, Masahiro Nakamori, Mineka Yoshikawa, Tomohisa Nezu, Satoshi Kubo, Yuka Nagano, Akiko Nagao, Naoya Yamane, Yuichi Nishikawa, Megumi Takamoto, Hiroki Ueno, Kazuhide Ochi, Hirofumi Maruyama, Hiromi Yamamoto, Masayasu Matsumoto
  • Journal Title: PLoS One Volume: 11 Issue: 5 Pages: e0154608-e0154608
  • DOI: 10.1371/journal.pone.0154608
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of pneumonia in acute stroke patients using tongue pressure measurements (2016)
  • Author(s): Masahiro Nakamori, Naohisa Hosomi, Kenichi Ishikawa, Eiji Imamura, Takeo Shishido, Tomohiko Ohshita, Mineka Yoshikawa, Kazuhiro Tsuga, Shinichi Wakabayashi, Hirofumi Maruyama, Masayasu Matsumoto
  • Journal Title: PLOS ONE Volume: 11 Issue: 11 Pages: e0165837-e0165837
  • DOI: 10.1371/journal.pone.0165837
  • Peer Reviewed / Open Access
• [Journal Article] Brain Natriuretic Peptide and Particular Left Ventricle Segment Asynergy Associated with Cardioembolic Stroke from Old Myocardial Infarction (2016)
  • Author(s): Hosomi N, Yoshimoto T, Kanaya Y, Neshige S, Hara N, Himeno T, Kono R, Takeshima S, Takamatsu K, Ota T, Miyamoto Y, Yasuda K, Shimoe Y, Ota T, Kuriyama M, Matsumoto M.
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 25 Issue: 5 Pages: 1165-1171
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.02.003
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Carotid Intima-Media Thickness for Atherosclerosis (2016)
  • Author(s): Nezu T, Hosomi N, Aoki S, Matsumoto M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 1 Pages: 18-31
  • DOI: 10.5551/jat.31989
  • NAID: 130005118661
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Multicenter Study of Intravenous Recombinant Tissue Plasminogen Activator Infusion around Hiroshima, Japan: The Hiroshima Acute Stroke Retrospective and Prospective Registry Study (2015)
  • Author(s): Aoki S, Hosomi N, Sueda Y, Kono T, Takamatsu K, Ohyama H, Torii T, Kitamura T, Nomura E, Noda K, Ohtsuki T, Matsumoto M, and the HARP Registry Study Group.
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 24 Issue: 12 Pages: 2747-2753
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.08.005
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Microbleeds evaluation study for prevention of brain hemorrhage in ischemic stroke (MB-evidence): pilot analysis for multicenter longitudinal study. (2017)
  • Author(s): Nezu T, Naka H, Hosomi N, Takamatsu K, Nomura E, Kitamura T, Torii T、Ohshita T, Nakamori M, Imamura E, Shimomura R, Aoki A, Maruyama H, Matsumoto M.
  • Organizer: XXIII World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] Stroke Recurrence or Death during 2 Weeks after Acute Ischemic Stroke with Atrial Fibrillation-Multicenter Prospective Registry in Hiroshima-. (2017)
  • Author(s): Nomura E, Ohshita T, Naka H, Matsushima H, Kubo S, Takeshima S, Imamura E, Torii T, Hosomi N, Maruyama H, Matsumoto M.
  • Organizer: XXIII World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] Characteristics and patterns of acute ischemic lesions in intracerebral hemorrhage. (2017)
  • Author(s): Aoki S, Hosomi N, Nezu T, Araki M, Matsushima H, Shimomura R, Kinoshita N, Maruyama H.
  • Organizer: XXIII World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] The risk of stroke induced by meteorological conditions in different sex and age groups: Hiroshima Emergency and Weather Study (HEWS) stroke collaboration. (2017)
  • Author(s): Tsunematsu M, Hosomi N, Mukai T, Sueda Y, Shimomura R, Maruyama H, Kakehashi M, Matsumoto M; on behalf of the Hiroshima ‘Emergency and Weather’ Study-stroke collaborators.
  • Organizer: World Congress of Epidemiology 2017.
  • Int'l Joint Research
• [Presentation] Probucol Increased Adrenal CYP11a1, HMGCoAR and VKORC1 Expression and Rescued LCAT Null Male Mice Propagation. (2017)
  • Author(s): Tsujita M, Takase H, Hosomi N, Akita N, Ohte N, Yamazaki T, Yokoyama S.
  • Organizer: The 20th International Conference on Cytochrome P450.
  • Int'l Joint Research
• [Presentation] 歯周病抗体価で脳梗塞患者の転帰を予測しえる？ (2017)
  • Author(s): 細見直永
  • Organizer: 2017年度生命科学系学会合同年次大会
  • Invited
• [Presentation] DOACによる心原性脳塞栓症予防治療の現状と今後の展開． (2017)
  • Author(s): 細見直永．
  • Organizer: 第20回日本臨床脳神経外科学会
  • Invited
• [Presentation] 気象変化と脳卒中． (2017)
  • Author(s): 向井智哉、細見直永、恒松美輪子、下村怜、梯正之、丸山博文、松本昌泰．
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] Carotid intima- media thickness: overview (2017)
  • Author(s): Nezu T, Hosomi N, Maruyama H
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] 歯周病菌感染症は脳梗塞に影響する？ (2017)
  • Author(s): 細見直永．
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] 頸動脈エコーを動脈硬化診療に活用する． (2017)
  • Author(s): 細見直永
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] 脳卒中再発予防、認知症発症予防を目標とした血圧管理． (2017)
  • Author(s): 細見直永．
  • Organizer: 第６回日本臨床高血圧フォーラム
  • Invited
• [Presentation] 脳梗塞の危険因子の管理． (2017)
  • Author(s): 細見直永．
  • Organizer: 第42回日本脳卒中学会総会
  • Invited
• [Presentation] 気象前線通過は脳梗塞発症頻度を増加する． (2017)
  • Author(s): 下村怜、細見直永、恒松美輪子、向井智哉、末田芳雅、丸山博文、梯正之、松本昌泰 、HEWS-stroke collaborators．
  • Organizer: 第42回日本脳卒中学会学術集会
• [Presentation] 舌圧測定は脳卒中患者の入院中肺炎発症を予測する． (2017)
  • Author(s): 中森正博、細見直永、今村栄次、前谷勇太、渡邉友彬、若林伸一、丸山博文、松本昌泰．
  • Organizer: 第42回日本脳卒中学会学術集会
• [Presentation] 血清α2マクログロブリンと血管内皮機能の関連性の検討 (2016)
  • Author(s): 下村怜、祢津智久、細見直永、木下直人、松島勇人、荒木睦子、青木志郎、丸山博文、松本昌泰
  • Organizer: 第59回日本脳循環代謝学会
  • Place of Presentation: 徳島
• [Presentation] 低酸素刺激下におけるtransmembrane protein 95 (TMEM95)の細胞内局在変化の検討 (2015)
  • Author(s): 下村怜、細見直永、倉重毅志ほか
  • Organizer: 第27回脳循環代謝学会
  • Place of Presentation: 富山
  • Year and Date: 2015-10-30