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Elucidation of mechanism on neuronal cell death and development of hemodiagnosis in ischemic stroke

Research Project

Project/Area Number 15K08615
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionHiroshima University

Principal Investigator

Hosomi Naohisa  広島大学, 医歯薬保健学研究科(医), 准教授 (70363190)

Co-Investigator(Kenkyū-buntansha) 高橋 哲也  広島大学, 病院(医), 講師 (00435942)
辻田 麻紀  名古屋市立大学, 大学院医学研究科, 講師 (10253262)
松本 昌泰  広島大学, 医歯薬保健学研究院(医), 教授 (20192346)
神沼 修  山梨大学, 総合研究部, 准教授 (80342921)
田中 茂  広島大学, 医歯薬保健学研究科(医), 講師 (20512651)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords脳卒中 / バイオマーカー / 脳梗塞
Outline of Final Research Achievements

We have tried to evaluate associations of transmembrane protein 95 on neuronal physiological function and ischemic neuronal cell death for elucidating a part of mechanism of neuronal cell death in ischemic stroke, And, we aimed to develop a hemodiagnosis in acute ischemic stroke with developing quantitive assay of transmembrane protein 95. We have created several antibodies against transmembrane protein 95 to construct ELISA system. Specificity and sensitivity of those antibodies were still on analysis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (27 results)

All 2018 2017 2016 2015

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (17 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results)

  • [Journal Article] Controlling Nutritional Status score for predicting 3-month functional outcome in acute ischemic stroke.2018

    • Author(s)
      Naito H, Nezu T, Hosomi N, Aoki S, Kinoshita N, Kuga J, Shimomura R, Araki M, Ueno H, Ochi K, Maruyama H.
    • Journal Title

      Nutrition.

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Charged Residues in the C-Terminal Domain of Apolipoprotein A-I Modulate Oligomerization2018

    • Author(s)
      Fuentes Lukas A.、Beck Wendy H. J.、Tsujita Maki、Weers Paul M. M.
    • Journal Title

      Biochemistry

      Volume: 57 Issue: 15 Pages: 2200-2210

    • DOI

      10.1021/acs.biochem.7b01052

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ischemic Stroke Mortality Is More Strongly Associated with Anemia on Admission Than with Underweight Status2017

    • Author(s)
      Kubo Satoshi、Hosomi Naohisa、Hara Naoyuki、Neshige Shuichiro、Himeno Takahiro、Takeshima Shinichi、Takamatsu Kazuhiro、Shimoe Yutaka、Ota Taisei、Maruyama Hirofumi、Ohtsuki Toshiho、Kuriyama Masaru、Matsumoto Masayasu
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 26 Issue: 6 Pages: 1369-1374

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.02.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Various meteorological conditions exhibit both immediate and delayed influences on the risk of stroke events: The HEWS stroke study2017

    • Author(s)
      Mukai Tomoya、Hosomi Naohisa、Tsunematsu Miwako、Sueda Yoshimasa、Shimoe Yutaka、Ohshita Tomohiko、Torii Tsuyoshi、Aoki Shiro、Nezu Tomohisa、Maruyama Hirofumi、Kakehashi Masayuki、Matsumoto Masayasu、on behalf of the Hiroshima ‘Emergency and Weather’ Study-stroke collaborators
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 6 Pages: e0178223-e0178223

    • DOI

      10.1371/journal.pone.0178223

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDL Biogenesis in Hepatocytes2017

    • Author(s)
      Maki Tsujita, Mohammad Anwar Hossain, Rui Lu, Tomoe Tsuboi, Kuniko Okumura-Noji and Shinji Yokoyama
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 11 Pages: 1132-1149

    • DOI

      10.5551/jat.39156

    • NAID

      130006191604

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The multidisciplinary swallowing team approach decreases pneumonia onset in acute stroke patients.2016

    • Author(s)
      Shiro Aoki, Naohisa Hosomi, Junko Hirayama, Masahiro Nakamori, Mineka Yoshikawa, Tomohisa Nezu, Satoshi Kubo, Yuka Nagano, Akiko Nagao, Naoya Yamane, Yuichi Nishikawa, Megumi Takamoto, Hiroki Ueno, Kazuhide Ochi, Hirofumi Maruyama, Hiromi Yamamoto, Masayasu Matsumoto
    • Journal Title

      PLoS One

      Volume: 11 Issue: 5 Pages: e0154608-e0154608

    • DOI

      10.1371/journal.pone.0154608

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of pneumonia in acute stroke patients using tongue pressure measurements2016

    • Author(s)
      Masahiro Nakamori, Naohisa Hosomi, Kenichi Ishikawa, Eiji Imamura, Takeo Shishido, Tomohiko Ohshita, Mineka Yoshikawa, Kazuhiro Tsuga, Shinichi Wakabayashi, Hirofumi Maruyama, Masayasu Matsumoto
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 11 Pages: e0165837-e0165837

    • DOI

      10.1371/journal.pone.0165837

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brain Natriuretic Peptide and Particular Left Ventricle Segment Asynergy Associated with Cardioembolic Stroke from Old Myocardial Infarction2016

    • Author(s)
      Hosomi N, Yoshimoto T, Kanaya Y, Neshige S, Hara N, Himeno T, Kono R, Takeshima S, Takamatsu K, Ota T, Miyamoto Y, Yasuda K, Shimoe Y, Ota T, Kuriyama M, Matsumoto M.
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 25 Issue: 5 Pages: 1165-1171

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.02.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Carotid Intima-Media Thickness for Atherosclerosis2016

    • Author(s)
      Nezu T, Hosomi N, Aoki S, Matsumoto M.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 1 Pages: 18-31

    • DOI

      10.5551/jat.31989

    • NAID

      130005118661

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multicenter Study of Intravenous Recombinant Tissue Plasminogen Activator Infusion around Hiroshima, Japan: The Hiroshima Acute Stroke Retrospective and Prospective Registry Study2015

    • Author(s)
      Aoki S, Hosomi N, Sueda Y, Kono T, Takamatsu K, Ohyama H, Torii T, Kitamura T, Nomura E, Noda K, Ohtsuki T, Matsumoto M, and the HARP Registry Study Group.
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 24 Issue: 12 Pages: 2747-2753

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.08.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Microbleeds evaluation study for prevention of brain hemorrhage in ischemic stroke (MB-evidence): pilot analysis for multicenter longitudinal study.2017

    • Author(s)
      Nezu T, Naka H, Hosomi N, Takamatsu K, Nomura E, Kitamura T, Torii T、Ohshita T, Nakamori M, Imamura E, Shimomura R, Aoki A, Maruyama H, Matsumoto M.
    • Organizer
      XXIII World Congress of Neurology.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stroke Recurrence or Death during 2 Weeks after Acute Ischemic Stroke with Atrial Fibrillation-Multicenter Prospective Registry in Hiroshima-.2017

    • Author(s)
      Nomura E, Ohshita T, Naka H, Matsushima H, Kubo S, Takeshima S, Imamura E, Torii T, Hosomi N, Maruyama H, Matsumoto M.
    • Organizer
      XXIII World Congress of Neurology.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characteristics and patterns of acute ischemic lesions in intracerebral hemorrhage.2017

    • Author(s)
      Aoki S, Hosomi N, Nezu T, Araki M, Matsushima H, Shimomura R, Kinoshita N, Maruyama H.
    • Organizer
      XXIII World Congress of Neurology.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The risk of stroke induced by meteorological conditions in different sex and age groups: Hiroshima Emergency and Weather Study (HEWS) stroke collaboration.2017

    • Author(s)
      Tsunematsu M, Hosomi N, Mukai T, Sueda Y, Shimomura R, Maruyama H, Kakehashi M, Matsumoto M; on behalf of the Hiroshima ‘Emergency and Weather’ Study-stroke collaborators.
    • Organizer
      World Congress of Epidemiology 2017.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Probucol Increased Adrenal CYP11a1, HMGCoAR and VKORC1 Expression and Rescued LCAT Null Male Mice Propagation.2017

    • Author(s)
      Tsujita M, Takase H, Hosomi N, Akita N, Ohte N, Yamazaki T, Yokoyama S.
    • Organizer
      The 20th International Conference on Cytochrome P450.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯周病抗体価で脳梗塞患者の転帰を予測しえる?2017

    • Author(s)
      細見直永
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] DOACによる心原性脳塞栓症予防治療の現状と今後の展開.2017

    • Author(s)
      細見直永.
    • Organizer
      第20回日本臨床脳神経外科学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 気象変化と脳卒中.2017

    • Author(s)
      向井智哉、細見直永、恒松美輪子、下村怜、梯正之、丸山博文、松本昌泰.
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Carotid intima- media thickness: overview2017

    • Author(s)
      Nezu T, Hosomi N, Maruyama H
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯周病菌感染症は脳梗塞に影響する?2017

    • Author(s)
      細見直永.
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 頸動脈エコーを動脈硬化診療に活用する.2017

    • Author(s)
      細見直永
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脳卒中再発予防、認知症発症予防を目標とした血圧管理.2017

    • Author(s)
      細見直永.
    • Organizer
      第6回日本臨床高血圧フォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 脳梗塞の危険因子の管理.2017

    • Author(s)
      細見直永.
    • Organizer
      第42回日本脳卒中学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 気象前線通過は脳梗塞発症頻度を増加する.2017

    • Author(s)
      下村怜、細見直永、恒松美輪子、向井智哉、末田芳雅、丸山博文、梯正之、松本昌泰 、HEWS-stroke collaborators.
    • Organizer
      第42回日本脳卒中学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 舌圧測定は脳卒中患者の入院中肺炎発症を予測する.2017

    • Author(s)
      中森正博、細見直永、今村栄次、前谷勇太、渡邉友彬、若林伸一、丸山博文、松本昌泰.
    • Organizer
      第42回日本脳卒中学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血清α2マクログロブリンと血管内皮機能の関連性の検討2016

    • Author(s)
      下村怜、祢津智久、細見直永、木下直人、松島勇人、荒木睦子、青木志郎、丸山博文、松本昌泰
    • Organizer
      第59回日本脳循環代謝学会
    • Place of Presentation
      徳島
    • Related Report
      2016 Research-status Report
  • [Presentation] 低酸素刺激下におけるtransmembrane protein 95 (TMEM95)の細胞内局在変化の検討2015

    • Author(s)
      下村怜、細見直永、倉重毅志ほか
    • Organizer
      第27回脳循環代謝学会
    • Place of Presentation
      富山
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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