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Preparation of guidelines for examination and diagnosis of antiphospholipid syndrome.

Research Project

Project/Area Number 15K08616
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionYamaguchi University

Principal Investigator

NOJIMA Junzo  山口大学, 大学院医学系研究科, 教授 (30448071)

Co-Investigator(Kenkyū-buntansha) 家子 正裕  北海道医療大学, 歯学部, 教授 (50250436)
Research Collaborator MOTOKI Yukari  
HARA Kazusa  
TAMARI Chikako  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords抗リン脂質抗体症候群 / 抗カルジオリピン抗体 / 抗β2グリコプロテインⅠ抗体 / ELISA / 抗リン脂質抗体 / ELISAキット / 動脈硬化症 / 酸化ストレス / 全身性エリテマトーデス / 組織因子 / 抗β2-グリコプロテインⅠ抗体
Outline of Final Research Achievements

We tried standardization of antiphospholipid antibodies ELISA in a joint research by three university hospitals participating in the Japan Antiphospholipid antibodies standardization workshop. Regarding the ten kinds of ELISA kits commercially available in Japan, we determined the reference range of healthy subjects. Furthermore, we clarified the combination of ELISA kits most suitable for the diagnosis of antiphospholipid syndrome.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (43 results)

All 2018 2017 2016 2015

All Journal Article (13 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (30 results) (of which Int'l Joint Research: 5 results,  Invited: 10 results)

  • [Journal Article] Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life.2018

    • Author(s)
      Mizuno K, Sasaki AT, Ebisu K, Tajima K, Kajimoto O, Nojima J, Kuratsune H, Hori H, Watanabe Y
    • Journal Title

      Med Gas Res.

      Volume: 7 Issue: 4 Pages: 247-255

    • DOI

      10.4103/2045-9912.222448

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Utility of Bartonella henselae IgM Western Blot Bands for Serodiagnosis of Cat Scratch Disease2017

    • Author(s)
      Otsuyama Ken-ichiro、Tsuneoka Hidehiro、Yoshidomi Hiroka、Haraguchi Mio、Yanagihara Masashi、Tokuda Nobuko、Nojima Junzo、Ichihara Kiyoshi
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 56 Issue: 1 Pages: 1-6

    • DOI

      10.1128/jcm.01322-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Detection of antibodies against domain 1 of β2-glycoprotein I is key in predicting thromboembolic complications in patients with systemic lupus erythematosus.2017

    • Author(s)
      Junzo Nojima, Yukari Motoki, Kazusa Hara, Toshiyuki Sakata, Hidehiro Tsuneoka, Kiyoshi Ichihara
    • Journal Title

      Thrombosis Research

      Volume: 153 Pages: 83-84

    • DOI

      10.1016/j.thromres.2017.02.001

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel enzyme immunoassay system for simultaneous detection of six subclasses of antiphospholipid antibodies for differential diagnosis of antiphospholipid syndrome.2017

    • Author(s)
      Junzo Nojima, Yukari Motoki, Kazusa Hara, Toshiyuki Sakata, Kiyoshi Ichihara
    • Journal Title

      Blood coagulation & fibrinolysis

      Volume: 印刷中 Issue: 4 Pages: 316-322

    • DOI

      10.1097/mbc.0000000000000599

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The utility of a country-specific Bartonella henselae antigen in an IgM-indirect fluorescent antibody assay for the improved diagnosis of cat scratch disease.2017

    • Author(s)
      Tsuneoka H, Yanagihara M, Tanimoto A, Tokuda N, Otsuyama KI, Nojima J, Ichihara K.
    • Journal Title

      Diagn Microbiol Infect Dis

      Volume: 87 Issue: 1 Pages: 22-24

    • DOI

      10.1016/j.diagmicrobio.2016.10.015

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity.2016

    • Author(s)
      Fukuda, S., Nojima, J., Motoki, Y., Yamaguti, K., Nakatomi, Y., Okawa, N., Fujiwara, K., Watanabe, Y., Kuratsune, H.
    • Journal Title

      Biol. Psychol.

      Volume: 118 Pages: 88-93

    • DOI

      10.1016/j.biopsycho.2016.05.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ubiquinol-10 supplementation improves fatigue, autonomic nervous function, and cognitive function in patients with chronic fatigue syndrome: An open-label study and a randomized, double-blind, placebo-controlled study.2016

    • Author(s)
      Fukuda, S., Nojima, J., Kajimoto, O., Yamaguti, K., Nakatomi, Y., Kuratsune, H., Watanabe, Y.
    • Journal Title

      Biofactors

      Volume: 8 Issue: 4 Pages: 431-440

    • DOI

      10.1002/biof.1293

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Profiles of direct oral anticoagulants and clinical usage-dosage and dose regimen differences.2016

    • Author(s)
      Ieko M, Naitoh S, Yoshida M, Takahashi N.
    • Journal Title

      J Intensive Care.

      Volume: 10 Issue: 1 Pages: 4-19

    • DOI

      10.1186/s40560-016-0144-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 抗リン脂質抗体症候群-分かったこと、分からないこと-2016

    • Author(s)
      家子正裕
    • Journal Title

      日本検査血液学会雑誌

      Volume: 17 Pages: 61-69

    • Related Report
      2015 Research-status Report
  • [Journal Article] 抗リン脂質抗体症候群の鑑別診断検査法の確立と病態発症機序の解明2015

    • Author(s)
      野島順三
    • Journal Title

      臨床検査学教育

      Volume: 7 Pages: 106-110

    • NAID

      40020378963

    • Related Report
      2015 Research-status Report
  • [Journal Article] The production of coagulation factor VII by adipocytes is enhanced by tumor necrosis factor-α or isoproterenol2015

    • Author(s)
      N Takahashi, T Yoshizaki, N Hiranaka, O Kumano, T Suzuki, M Akanuma, T Yui, K Kanazawa, M Yoshida, S Naito, M Fujiya, Y Kohgo, M Ieko
    • Journal Title

      International Journal of Obesity

      Volume: 39 Issue: 5 Pages: 747-754

    • DOI

      10.1038/ijo.2014.208

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome.2015

    • Author(s)
      Ebina Y, Ieko M, Naito S, Kobashi G, Deguchi M, Minakami H, Atsumi T, Yamada H.
    • Journal Title

      Thromb Haemost.

      Volume: 114 Issue: 07 Pages: 65-69

    • DOI

      10.1160/th14-11-0928

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抗リン脂質抗体症候群の病態と検査-特にループスアンチコアグラントによる特殊病態-2015

    • Author(s)
      家子正裕、内藤済悦、吉田美香、高橋伸彦
    • Journal Title

      臨床病理

      Volume: 63 Pages: 1220-1227

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗リン脂質抗体症候群における血栓症発症機序の解明2018

    • Author(s)
      金重里沙,野島順三
    • Organizer
      第18回TTMフォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗リン脂質抗体症候群,最近の話題と展望2018

    • Author(s)
      野島順三
    • Organizer
      第21回積水セミナー 学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗リン脂質抗体症候群における血栓症発症機序の解明2017

    • Author(s)
      金重里沙,坂本萌絵,本木由香里,野島順三.
    • Organizer
      第8回TTMフォーラム九州
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心停止後症候群の予後推測因子としての相対的酸化ストレス度2017

    • Author(s)
      坂本萌絵,金重里沙,本木由香里,野島順三
    • Organizer
      第8回TTMフォーラム九州
    • Related Report
      2017 Annual Research Report
  • [Presentation] 疲労を科学する2017

    • Author(s)
      野島順三
    • Organizer
      第48回日本看護学会-ヘルスプロモーション-学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 抗リン脂質抗体症候群における脳梗塞発症機序の解明2017

    • Author(s)
      田島里紗,本木由香里,野島順三
    • Organizer
      第12回日本臨床検査学教育学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生理的疲労と病的疲労の鑑別検査法確立と病的疲労形成に対する抗酸化サプリメントの効果検証2017

    • Author(s)
      坂本萌絵,本木由香里,野島順三
    • Organizer
      第12回日本臨床検査学教育学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗リン脂質抗体による後天性活性化プロテインCレジスタンス2017

    • Author(s)
      金重里沙,本木由香里,野島順三
    • Organizer
      第18回日本検査血液学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗リン脂質抗体による活性化プロテイン C 系凝固制御機構の阻害作用.2016

    • Author(s)
      金重里沙、原和冴、本木由香里、野島順三.
    • Organizer
      第49回日本臨床衛生検査技師会中四国支部医学検査学会
    • Place of Presentation
      高知県 (高知市文化プラザかるぽーと)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 全血法フローサイトメトリーによる活性化血小板及び活性化血小板-単球複合体定量法2016

    • Author(s)
      我毛美鈴,玉利知佳子,本木由香里,野島順三.
    • Organizer
      第49回日本臨床衛生検査技師会中四国支部医学検査学会
    • Place of Presentation
      高知県 (高知市文化プラザかるぽーと)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Novel enzyme immunoassay system for simultaneous detection of six subclasses of anti-phospholipid antibodies for differential diagnosis of anti-phospholipid syndrome.2016

    • Author(s)
      Hara K, Motoki Y, Sakata T, Nojima J.
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science.
    • Place of Presentation
      Kobe International Conference Center, Japan
    • Year and Date
      2016-08-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗リン脂質抗体症候群の病態に対する酸化ストレスの影響2016

    • Author(s)
      村田知奈美,原和冴,玉利知佳子,本木由香里,野島順三
    • Organizer
      第16回 TTMフォーラム
    • Place of Presentation
      東京(大手町サンケイプラザ)
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗リン脂質抗体症候群の疾患概念と検査診断プロセス2016

    • Author(s)
      野島順三
    • Organizer
      第3回九州凝固検査共同研究会
    • Place of Presentation
      熊本(アークホテル熊本城前)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 日本における抗リン脂質抗体ELISAの標準化に向けて -第2報-2016

    • Author(s)
      本木由香里,吉田美香,關谷暁子,原和冴,家子正裕,森下英理子,野島順三
    • Organizer
      第10回日本血栓止血学会学術標準化委員会(SSC)シンポジウム
    • Place of Presentation
      東京(野村コンファレンスプラザ日本橋)
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗リン脂質抗体による活性化プロテインC系凝固制御機構の阻害作用.2016

    • Author(s)
      金重里沙,原和冴,本木由香里,野島順三.
    • Organizer
      第7回TTMフォーラム九州
    • Place of Presentation
      福岡県(ホテルレオパレス博多)
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗リン脂質抗体による血小板活性化および血小板-白血球複合体形成作用.2016

    • Author(s)
      我毛美鈴,玉利知佳子,本木由香里,野島順三.
    • Organizer
      第7回TTMフォーラム九州
    • Place of Presentation
      福岡県(ホテルレオパレス博多)
    • Related Report
      2016 Research-status Report
  • [Presentation] Antiphospholipid syndrome and lupus anticoagulant.2015

    • Author(s)
      Ieko M
    • Organizer
      XXVIII World Congress of the World Association of Societies of Pathology Laboratory Medicine.
    • Place of Presentation
      Cancun, Mexico
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ループスアンチコアグラント活性迅速鑑別検査法の確立2015

    • Author(s)
      玉利知佳子、井手紬、原和冴、村田知奈美、本木由香里、野島順三
    • Organizer
      第6回TTMフォーラム九州
    • Place of Presentation
      福岡(ホテルレオパレス博多)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] Multiplex-aPLs-EIAシステムによる抗リン脂質抗体検査診断法の確立2015

    • Author(s)
      原和冴, 玉利知佳子, 村田知奈美, 本木由香里, 野島順三
    • Organizer
      第6回TTMフォーラム九州
    • Place of Presentation
      福岡(ホテルレオパレス博多)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗リン脂質抗体症候群の疾患概念と検査診断プロセス2015

    • Author(s)
      野島順三
    • Organizer
      第1回 Werfen血液凝固セミナー
    • Place of Presentation
      東京(東京コンファレンスセンター・品川))
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ストレス・疲労の本質「酸化ストレス」の実態に迫る2015

    • Author(s)
      野島順三
    • Organizer
      第19回日本看護管理学会学術集会
    • Place of Presentation
      福島(ビックパレットふくしま)
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 山口大学大学院修士課程における臨床検査技師の特色ある教育-臨床培養士養成課程の開設2015

    • Author(s)
      野島順三
    • Organizer
      第10回日本臨床検査学教育学会学術大会
    • Place of Presentation
      長野(信州大学医学部地域保健推進センター)
    • Year and Date
      2015-08-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 抗リン脂質抗体症候群の疾患概念と検査診断プロセス2015

    • Author(s)
      野島順三
    • Organizer
      徳島県血液検査研究班勉強会
    • Place of Presentation
      徳島 (徳島大学病院)
    • Year and Date
      2015-08-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Thrombomodulin down-regulation is related to the thrombosis risk in antiphospholipid syndrome patients.2015

    • Author(s)
      Osamu Kumano, Masahiro Ieko , Sumiyoshi Naito, Mika Yoshida, Nobuhiko Takahashi, Takeshi Suzuki, Takashi Aoki
    • Organizer
      XXV Congress of the International Society on Thrombosis and Haemostasis.61st Annual SSC Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Usefulness of various scoring methods with cross-mixing test for detection of lupus anticoagulant.2015

    • Author(s)
      Sumiyoshi Naito, Masahiro Ieko , Osamu Kumano, Mika Yoshida, Nobuhiko Takahashi, Takeshi Suzuki, Akihide Ito, Nobutaka Wakamiya
    • Organizer
      XXV Congress of the International Society on Thrombosis and Haemostasis.61st Annual SSC Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] New mixing test index to discriminate between lupus anticoagulant and coagulatin inhibitor.2015

    • Author(s)
      Osamu Kumano, Masahiro Ieko , Sumiyoshi Naito, Mika Yoshida, Nobuhiko Takahashi, Takeshi Suzuki, Takashi Aoki
    • Organizer
      XXV Congress of the International Society on Thrombosis and Haemostasis.61st Annual SSC Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗リン脂質抗体症候群の検査診断確立への新展開2015

    • Author(s)
      野島順三
    • Organizer
      第37回日本血栓止血学会学術集会
    • Place of Presentation
      山梨 (甲府市総合市民会館)
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 相対的酸化ストレス度は、生命力を評価できるか?2015

    • Author(s)
      野島順三
    • Organizer
      第11回日本疲労学会学術集会
    • Place of Presentation
      山口 (山口県総合保健会館)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 心停止後症候群の予後推測因子としての相対的酸化ストレス度2015

    • Author(s)
      原和冴, 玉利知佳子, 村田知奈美, 本木由香里, 野島順三
    • Organizer
      第11回日本疲労学会学術集会
    • Place of Presentation
      山口 (山口県総合保健会館)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 相対的酸化ストレス度を用いた東日本大震災被災者の疲労度評価2015

    • Author(s)
      本木由香里, 常岡英弘, 野島順三
    • Organizer
      第11回日本疲労学会学術集会
    • Place of Presentation
      山口 (山口県総合保健会館)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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