Development of diagnostic method for efficacy of sublingual immunotherapy based on systematic genome wide analysis

• Project/Area Number: 15K08626
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Nippon Medical School
• Principal Investigator: Gotoh Minoru 日本医科大学, 医学部, 准教授 (80281426)
• Co-Investigator(Kenkyū-buntansha): 神沼 修 山梨大学, 大学院総合研究部, 准教授 (80342921) ; 中谷 明弘 大阪大学, 医学系研究科, 特任教授(常勤) (60301149)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 舌下免疫療法 / スギ花粉症 / アレルギー性鼻炎 / 統合解析 / 苦味受容体 / アレルゲン免疫療法 / ゲノムワイド解析

Outline of Final Research Achievements

It is difficult to predict the treatment effect as one of the problems hindering the spread of sublingual immunotherapy. If high-precision biomarkers can be identified, prediction can be made before treatment and judgment of therapeutic indication can be facilitated.
Comparison of gene expression between HR and NR before and after sublingual immunotherapy treatment showed that the expression of bitter taste receptor was high in the HR group. The possibility that bitter substances may influence the therapeutic effect of sublingual immunotherapy via bitter taste receptors was considered.

Research Products

• [Journal Article] Involvement of taste receptors in the effectiveness of sublingual immunotherapy (2018)
  • Author(s): Gotoh Minoru、Kaminuma Osamu、Nakaya Akihiro、Katayama Kazufumi、Watanabe Nobumasa、Saeki Mayumi、Nishimura Tomoe、Kitamura Noriko、Okubo Kimihiro、Hiroi Takachika
  • Journal Title: Allergology International Volume: 67 Issue: 3 Pages: 421-424
  • DOI: 10.1016/j.alit.2018.02.003
  • NAID: 130007420446
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis (2017)
  • Author(s): Gotoh Minoru、Kaminuma Osamu、Nakaya Akihiro、Katayama Kazufumi、Motoi Yuji、Watanabe Nobumasa、Saeki Mayumi、Nishimura Tomoe、Kitamura Noriko、Yamaoka Kazuko、Okubo Kimihiro、Hiroi Takachika
  • Journal Title: Int Immunol Volume: 29 Issue: 6 Pages: 291-300
  • DOI: 10.1093/intimm/dxx034
  • Peer Reviewed / Open Access
• [Presentation] アレルゲン免疫療法の現状 (2017)
  • Author(s): 後藤穣
  • Organizer: 第５６回日本鼻科学会
  • Invited
• [Presentation] スギ花粉症に対する舌下免疫療法 (2017)
  • Author(s): 後藤穣
  • Organizer: 第６６回日本アレルギー学会
  • Invited
• [Presentation] アレルゲン舌下免疫療法の最新知見 (2017)
  • Author(s): 後藤穣
  • Organizer: 第35回耳鼻咽喉科免疫アレルギー学会
  • Invited