Elucidation of lipid metabolizing enzyme dynamics as a predictor of cardiovascular events
| Project/Area Number |
15K08627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川尻 剛照 金沢大学, 医学系, 准教授 (90345637)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Hayato 金沢大学, 附属病院, 助教 (90623653)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リポ蛋白リパーゼ / 肝性リパーゼ / 血管内皮リパーゼ / GPIHBP１ / 頚動脈エコー / 内膜中膜複合体厚 / ELISA / 家族性高コレステロール血症 |
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| Outline of Final Research Achievements |
It is not clear how the lipid metabolizing enzyme affects arteriosclerosis. In this study, we investigated the relationship of serum lipoprotein lipase (LPL), serum HL protein, vascular endothelial lipase (EL), and glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPI-HBP1) to the degree of arteriosclerosis in patients with familial hypercholesterolemia. As a result, it was suggested that EL and GPIHBP1 are predictors of arteriosclerotic progression, while HTGL and LPL do not necessarily reflect arteriosclerotic severity of the carotid artery.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Triglyceride content in remnant lipoproteins is significantly increased after food intake and is associated with plasma lipoprotein lipase.2017
Author(s)
Nakajima K, Tokita Y, Sakamaki K, Shimomura Y, Kobayashi J, Kamachi K, Tanaka A, Stanhope KL, Havel PJ, Wang T, Machida T, Murakami M.
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Journal Title
Clinica Chimica Acta
Volume: 465
Pages: 45-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Lipoprotein lipase does not increase significantly in the postprandial plasma.2017
Author(s)
Ishiyama N, Sakamaki K, Shimomura Y, Kotani K, Tsuzaki K, Sakane N, Miyashita K, Fukamachi I, Kobayashi J, Stanhope KL, Havel PJ, Kamachi K, Tanaka A, Tokita Y, Machida T, Murakami M, Nakajima K.
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Journal Title
Clinica Chimica Acta
Volume: 464
Pages: 204-210
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Sex Differences in Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women2016
Author(s)
Sakurai M, Kobayashi J, Takeda Y, Nagasawa SY, Yamakawa J, Moriya J, Mabuchi H, Nakagawa H
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Journal Title
Journal of Epidemiology
Volume: 26
Issue: 8
Pages: 440-446
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed / Open Access
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[Journal Article] The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins.2016
Author(s)
Sato K, Okajima F, Miyashita K, Imamura S, Kobayashi J, Stanhope KL, Havel PJ, Machida T, Sumino H, Murakami M, Schaefer E, Nakajima K.
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Journal Title
Clin Chim Acta
Volume: 461
Pages: 114-125
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Lipase and the metabolism of triglyceride-rich lipoproteins2016
Author(s)
Kobayashi J, Miyashita K, Nakajima K
Organizer
5th International Symposium on Chylomicrons, Very Low Density Lipoproteins, and Remnant Lipoproteins
Place of Presentation
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University（Boston, MA、米国）
Year and Date
2016-11-08
Related Report
Int'l Joint Research / Invited
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