| Project/Area Number |
15K08627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川尻 剛照 金沢大学, 医学系, 准教授 (90345637)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Hayato 金沢大学, 附属病院, 助教 (90623653)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リポ蛋白リパーゼ / 肝性リパーゼ / 血管内皮リパーゼ / GPIHBP１ / 頚動脈エコー / 内膜中膜複合体厚 / ELISA / 家族性高コレステロール血症 |
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| Outline of Final Research Achievements |
It is not clear how the lipid metabolizing enzyme affects arteriosclerosis. In this study, we investigated the relationship of serum lipoprotein lipase (LPL), serum HL protein, vascular endothelial lipase (EL), and glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPI-HBP1) to the degree of arteriosclerosis in patients with familial hypercholesterolemia. As a result, it was suggested that EL and GPIHBP1 are predictors of arteriosclerotic progression, while HTGL and LPL do not necessarily reflect arteriosclerotic severity of the carotid artery.
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