Developing novel blood-based protein biomarker for schizophrenia
| Project/Area Number |
15K08633
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Shimane University (2017)
Kitasato University (2016)
National Institute of Radiological Sciences (2015) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 統合失調症 / 血清バイオマーカー / MIAモデル / 血液バイオマーカー / 免疫 / バイオマーカー / 血清診断マーカー / ＭＩＡ |
|---|
| Outline of Final Research Achievements |
Although several studies have been published that searched for clues to serodiagnostic markers of schizophrenia, serodiagnostic biomarkers for the patient have yet to become entrenched. Although the whole picture of the MIA model animal phenotype has not yet been clarified, we herein suggest its usefulness in our quest for serodiagnostic biomarkers of sporadic schizophrenia. We found augmentation of immunoglobulin (Ig) κ; light chain in the serum proteome of the MIA model rats. We thereby studied Ig light chain contents in the commercially available sera of patients with sporadic schizophrenia to find elevation of both free Ig light chains (FLC). Our results imply that serum FLC assay together with pro-inflammatory cytokine measurements would be of use to stratify the MIA-associated subgroup among schizophrenia patient population and thereby to realize a serodiagnostic test for diagnosis of sporadic schizophrenia subpopulation.
|
Report
(4 results)
Research Products
(8 results)
