| Project/Area Number |
15K08634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Department of Clinical Research, National Hospital Organization Kyoto Medical Center |
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Principal Investigator |
Satoh-Asahara Noriko 独立行政法人国立病院機構(京都医療センター臨床研究センター), 内分泌代謝高血圧研究部, 研究部長 (80373512)
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| Co-Investigator(Kenkyū-buntansha) |
長谷川 浩二 独立行政法人国立病院機構(京都医療センター臨床研究センター), 展開医療研究部, 研究部長 (50283594)
小谷 和彦 自治医科大学, 医学部, 教授 (60335510)
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| Co-Investigator(Renkei-kenkyūsha) |
Suganami Takayoshi 名古屋大学, 環境医学研究所, 教授 (50343752)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病 / 肥満 / 単球 / マクロファージ / ミクログリア / 炎症 / 脳心血管疾患 / 認知症 / 血管合併症 |
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| Outline of Final Research Achievements |
In the present study, we demonstrated that in obese/diabetic settings, exacerbation of pro-inflammatory M1/anti-inflammatory M2 type in monocytes was closely implicated in the development/progression of atherosclerosis, based on the multicenter prospective cohort study and the animal study. Additionally, we identified the gene triggering receptor expressed on myeloid cells 2 (TREM2) as a potential novel molecule involving the obesity/diabetes-related aggravation of M1/M2 type, which was found in bone marrow monocytes in obese/diabetic conditions. We further showed that serum TREM2 levels might be a potential novel marker of the diabetes-related cognitive impairment in diabetic patients. Our findings should contribute to the elucidation of the mechanisms underlying the development/progression of obesity/diabetes-related complications and the development of novel predictive markers and effective treatments for these complications.
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