Development of novel treatments of myeloma based on MRD using next-generation sequencing and protein-array assay
| Project/Area Number |
15K08644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIKAWA Hiroyoshi 国立がん研究センター, 先端医療開センター, 免疫TR分野長 (10444431)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 多発性骨髄腫 / 微小残存病変 / 癌精巣抗原 / 次世代シークエンサー / マルチパラメーターフローサイトメトリー / 自己抗体 / ディジタルPCR / リアルタイムPCR |
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| Outline of Final Research Achievements |
We demonstrated the clinical value of minimal residual disease (MRD) detection in multiple myeloma (MM) patients using next-generation sequencing (NGS) and multiparameter flow cytometry (MFC). When MRD negativity in bone marrow and/or autografts of MM patients was achieved, the progression-free survival and overall survival were dramatically improved. Based on the results, we have started the clinical study "Prognostic value of minimal residual disease detection using multiparameter flow cytometry (EuroFlow method) in patients with multiple myeloma who underwent autologous stem cell transplantation: comparison with sequencing-based method (UMIN-CTR ID: UMIN000022238)". On the other hand, we clarified that anti-X antibody which is detected in the sera of MRD negative MM patients binds to a cancer-testis antigen X.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia2017
Author(s)
Yoshitaka Zaimoku*, Hiroyuki Takamatsu*, Kazuyoshi Hosomichi*, Tatsuhiko Ozawa, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Takamasa Katagiri, Hiroyuki Kishi, Atsushi Tajima, Atsushi Muraguchi, Koichi Kashiwase, and Shinji Nakao , *: contributed equally
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Journal Title
Blood
Volume: 129
Pages: 2908-2916
Related Report
Peer Reviewed
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[Journal Article] Changing trends in prognostic factors for patients with multiple myeloma after autologous stem cell transplantation during the immunomodulator drug/proteasome inhibitor era2015
Author(s)
Hiroyuki Takamatsu, Sumihisa Honda, Toshihiro Miyamoto, Kenji Yokoyama, Shotaro Hagiwara, Toshiro Ito, Naoto Tomita, Shinsuke Iida, Toshihiro Iwasaki, Hisashi Sakamaki, Ritsuro Suzuki, Kazutaka Sunami.
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Journal Title
Cancer Science
Volume: 106
Issue: 2
Pages: 179-185
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cord Blood Transplantation for Multiple Myeloma: A Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation2015
Author(s)
Kawamura K, Takamatsu H, Ikeda T, Komatsu T, Aotsuka N, Amano I, Yamamoto G, Watanabe K, Ohno Y, Matsue K, Kouzai Y, Tsukada N, Ishiyama K, Anzai N, Kato K, Suzuki R, Sunami K, Kanda Y
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Journal Title
Biol Blood Marrow Transplant
Volume: 21
Issue: 7
Pages: 1291-1298
DOI
Related Report
Peer Reviewed
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[Presentation] A Comparison of Minimal Residual Disease Detection Among ASOPCR, Dd-PCR and Deep-Sequencing in Patients with Multiple Myeloma Who Underwent Autologous Stem Cell Transplantation2015
Author(s)
Rachel K Wee, Hiroyuki Takamatsu, Ryoichi Murata, Jianbiao Zheng, Martin Moorhead, Naoki Takezako, Shigeki Ito, Toshihiro Miyamoto, Kenji Yokoyama, Kosei Matsue, Tsutomu Sato, Toshiro Kurokawa, Hideo Yagi, Yasushi Terasaki, Kinya Ohata, Takashi Yoshida, Malek Faham and Shinji Nakao
Organizer
米国血液学会
Place of Presentation
ORLANDO, USA
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] Prognostic Value of Sequencing-Based Minimal Residual Disease Detection in Patients with Multiple Myeloma Who Underwent Autologous Stem Cell Transplantation2015
Author(s)
Hiroyuki Takamatsu, Ryoichi Murata, Jianbiao Zheng, Martin Moorhead, Naoki Takezako, Shigeki Ito,Toshihiro Miyamoto, Kenji Yokoyama, Kosei Matsue, Tsutomu Sato, Toshiro Kurokawa, Hideo Yagi, Yasushi Terasaki, Kinya Ohata, Takashi Yoshida, Malek Faham, Shinji Nakao
Organizer
米国血液学会
Place of Presentation
ORLANDO, USA
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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