Examination of prethrombotic state to prevent thrombosis

• Project/Area Number: 15K08645
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Mie University
• Principal Investigator: Wada Hideo 三重大学, 医学系研究科, 准教授 (40158704)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 前血栓症 / 止血系マーカー / 遺伝子異常 / TMA / VTE / DIC / APTT波形 / D-dimer / 抗Xa活性 / 遺伝子解析 / aHUS / SF / thrombotic state / 遺伝子変異 / 補体 / PE / DVT / diagnosis / prediction

Outline of Final Research Achievements

Various hemostatic markers were significantly increased or decreased. The cutoff value of D-dimer and SF were determined to diagnose or predict thrombosis. AT, PC or PS abnormalities were frequently diagnosed by genetic analysis in VTE patients and the polymorphism of Fibrinogen αchain were significantly higher in female infertility than in healthy pregnant women. In Kinki area, C3I1157T variant was detected in 14 cases of aHUS patients. Several carrier who had genetic variant, had no symptom. The diagnostic criteria established by Japanese Society of Thrombosis and Hemostasis using AT, TAT, SF and decreased platelet count was significantly more useful than other diagnostic criteria for diagnosing DIC or Pre-DIC.

Academic Significance and Societal Importance of the Research Achievements

前血栓症状態を定義すれば、血栓症発症前診断が可能になる。血栓症発症前に抗血栓薬の予防投与を行えば、生命予後ならびに患者のQOLの改善につながる。また、血栓症発症を防ぐことにより、医療費を大幅に削減することができる。
本研究により、遺伝子診断が普及し、止血分子マーカーのカットオフ値が確立されると、早期の血栓症ならびに前血栓症状態の診断が普及し、容易になる。

Research Products

• [Journal Article] A re-evaluation of the D-dimer cut-off value for making a diagnosis according to the ISTH overt-DIC diagnostic criteria: communication from the SSC of the ISTH. (2018)
  • Author(s): Suzuki K, Wada H, Imai H, Iba T, Thachil J, Toh CH
  • Journal Title: J Thromb Haemost Volume: 16 Issue: 7 Pages: 1442-1444
  • DOI: 10.1111/jth.14134
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Congenital Thrombophilia in Patients With Superior Mesenteric Venous Thrombosis or Portal Vein Thrombosis. (2018)
  • Author(s): Ikejiri M, Usui M, Wada H, Matsumoto T, Ohishi K, Shindo A, Yamashita Y, Nakatani K, Tamaki S, Tomimoto H, Isaji S
  • Journal Title: Clin Appl Thromb Hemost Volume: 24 Issue: 7 Pages: 1117-1121
  • DOI: 10.1177/1076029618774146
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical manifestation of patients with atypical hemolytic uremic syndrome with the C3 p.I1157T variation in the Kinki region of Japan. (2018)
  • Author(s): Matsumoto T, Toyoda H, Amano K, Hirayama M, Ishikawa E, Fujimoto M, Ito M, Ohishi K, Katayama N, Yoshida Y, Matsumoto M, Kawamura N, Ikejiri M, Kawakami K, Miyata T, Wada H
  • Journal Title: Clin Appl Thromb Hemost Volume: 24 Issue: 8 Pages: 1301-1307
  • DOI: 10.1177/1076029618771750
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The evaluation of D-dimer levels for the comparison of fibrinogen and fibrin units using different D-dimer kits to diagnose VTE (2018)
  • Author(s): Hasegawa M, Wada H, Yamaguchi T, Wakabayashi H, Fujimoto N, Matsumoto T, Hasegawa K, Yamada N, Ito M, Yamashita Y, Katayama N, Nakatani K, Sudo A
  • Journal Title: Clin Appl Thromb Hemost Volume: 24 Issue: 4 Pages: 655-662
  • DOI: 10.1177/1076029617706755
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Monitoring of hemostatic abnormalities in major orthopedic surgery patients treated with edoxaban by APTT waveform (2018)
  • Author(s): Hasegawa M, Wada H, Tone S, Yamaguchi T, Wakabayashi H, Ikejiri M, Watanabe M, Fujimoto N, Matsumoto T, Ohishi K, Yamashita Y, Katayama N, Sudo A
  • Journal Title: Int J Lab Hematol Volume: 40 Issue: 1 Pages: 49-55
  • DOI: 10.1111/ijlh.12727
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Proposal of the Modification of Japanese Society on Thrombosis and Hemostasis (JSTH) Disseminated Intravascular Coagulation (DIC) Diagnostic Criteria for Sepsis-Associated DIC. (2018)
  • Author(s): Iba T, Di Nisio M, Thachil J, Wada H, Asakura H, Sato K, Saitoh D
  • Journal Title: Clin Appl Thromb Hemost Volume: 24 Issue: 3 Pages: 439-445
  • DOI: 10.1177/1076029617720069
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Platelet Activation Assessed by Glycoprotein VI/Platelet Ratio Is Associated With Portal Vein Thrombosis After Hepatectomy and Splenectomy in Patients With Liver Cirrhosis. (2018)
  • Author(s): Matsui T, Usui M, Wada H, Iizawa Y, Kato H, Tanemura A, Murata Y, Kuriyama N, Kishiwada M, Mizuno S, Sakurai H, Isaji S
  • Journal Title: Clin Appl Thromb Hemost. Volume: 24 Issue: 2 Pages: 254-262
  • DOI: 10.1177/1076029617725600
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform. (2018)
  • Author(s): Katayama H, Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Habe K, Katayama N:
  • Journal Title: Clin Appl Thromb Hemost Volume: open ac Issue: 7 Pages: 1170-1176
  • DOI: 10.1177/1076029618757344
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elevated Soluble Platelet Glycoprotein VI Levels in Patients After Living Donor Liver Transplantation. (2017)
  • Author(s): Takahashi N, Usui M, Naitoh K, Wada H, Mastsui T, Kobayashi T, Matsumoto T, Uemoto S, Isaji S
  • Journal Title: Clin Appl Thromb Hemost. Volume: 23 Issue: 3 Pages: 274-281
  • DOI: 10.1177/1076029615604047
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] High prevalence of congenital thrombophilia in patients with pregnancy-related or idiopathic venous thromboembolism/pulmonary embolism. (2017)
  • Author(s): Ikejiri M, Wada H, Yamada N, Nakamura M, Fujimoto N, Nakatani K, Matsuda A, Ogihara Y, Matsumoto T, Kamimoto Y, Ikeda T, Katayama N, Ito M
  • Journal Title: Int J Hematol Volume: 105 Issue: 3 Pages: 272-279
  • DOI: 10.1007/s12185-016-2111-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Attempt to Harvest a Sufficient Number of Mononuclear Cells in an Appropriate Blood Product Volume By Modification of the Default Apheresis Setting. (2017)
  • Author(s): Tanaka Y, Ohishi K, Sawai T, Iwasaki H, Kageyama S, Masuya M, Matsumoto T, Tanigawa T, Wada H, Shiku H, Ito M, Katayama N
  • Journal Title: Ther Apher Dial. Volume: 21 Issue: 5 Pages: 507-511
  • DOI: 10.1111/1744-9987.12562
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An Evaluation of the Activated Partial Thromboplastin Time Waveform (2017)
  • Author(s): Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Hasegawa K, Suzuki K, Imai H, Nakatani K, Katayama N
  • Journal Title: Clin Appl Thromb Hemost Volume: Epub Issue: 5 Pages: 764-770
  • DOI: 10.1177/1076029617724230
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant. (2017)
  • Author(s): Ikejiri M, Wada H, Tone S, Wakabayashi H, Hasegawa M, Matsumoto T, Fujimoto N, Yamada N, Ito M, Nakatani K, Sudo A .
  • Journal Title: Thromb J Volume: open ac Issue: 1
  • DOI: 10.1186/s12959-017-0150-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis (2017)
  • Author(s): Habe K, Wada H, Higashiyama A, Akeda T, Tsuda K, Mori R, Kakeda M, Matsumoto T, Ohishi K, Yamanaka K, Katayama N, Mizutani H.
  • Journal Title: Clin Appl Thromb Hemost Volume: 23 Issue: 6 Pages: 622-630
  • DOI: 10.1177/1076029617736382
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] : Protection From Pregnancy Loss in Women With Hereditary Thrombophilia When Associated With Fibrinogen Polymorphism Thr331Ala. (2017)
  • Author(s): IKejiri M, Wada H, Kamimoto Y, Nakatani K, Ikeda T
  • Journal Title: Clin Appl Thromb Hemost Volume: 23 Issue: 5 Pages: 494-495
  • DOI: 10.1177/1076029616645400
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants.: Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) 2017 in Japan. (2017)
  • Author(s): Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M;
  • Journal Title: Int J Hematol Volume: 106 Issue: 1 Pages: 3-15
  • DOI: 10.1007/s12185-017-2264-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis.: The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis. (2017)
  • Author(s): Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Asakura H
  • Journal Title: Thromb J Volume: open ac Issue: 1 Pages: 17-17
  • DOI: 10.1186/s12959-017-0142-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Emicizumab Prophylaxis in Hemophilia A with Inhibitors. (2017)
  • Author(s): Wada H, Matsumoto T, Katayama N
  • Journal Title: N Engl J Med Volume: 377 Issue: 22 Pages: 2193-2194
  • DOI: 10.1056/nejmc1712683
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hypofibrinogenemia and the α-Fibrinogen Thr312Ala Polymorphism may be Risk Factors for Early Pregnancy Loss. (2017)
  • Author(s): Kamimoto Y, Wada H, Ikejiri M, Nakatani K, Sugiyama T, Osato K, Murabayashi N, Habe K, Mizutani H, Matsumoto T, Ohishi K, Ikeda T
  • Journal Title: Clin Appl Thromb Hemost Volume: 23 Issue: 1 Pages: 52-57
  • DOI: 10.1177/1076029615594003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of the Diagnostic Criteria for the Basic Type of DIC Established by the Japanese Society of Thrombosis and Hemostasis. (2017)
  • Author(s): Aota T, Wada H, Fujimoto N, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Uchiyama T, Seki Y, Katayama N.
  • Journal Title: Clin Appl Thromb Hemost. Volume: 印刷中 Issue: 7 Pages: 579-584
  • DOI: 10.1177/1076029616672582
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery. (2016)
  • Author(s): Hasegawa M, Wada H, Miyazaki S, Yamaguchi T, Wakabayashi H, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Yamashita Y, Katayama N, Nakatani K, Sudo A
  • Journal Title: Clin Appl Thromb Hemost Volume: - Issue: 1 Pages: 107-114
  • DOI: 10.1177/1076029616674824
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Supportive management strategies for disseminated intravascular coagulation-An international consensus, (2016)
  • Author(s): Squizzato A, Hunt BJ, Gary T. Kinasewitz GT, Wada H, ten Cate H, Thachil J, Levi M, Vicente V, Angelo AD, Di Nisio M
  • Journal Title: Thromb Haemost Volume: 115 Issue: 05 Pages: 896-904
  • DOI: 10.1160/th15-09-0740
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Fibrin-related markers for diagnosing acute-, subclinical-,and pre-venous thromboembolism in patients with major orthopedic surgery. (2016)
  • Author(s): Yamaguchi T, Wada H, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Yamashita Y, Katayama N, Sudo A.
  • Journal Title: Int J Hematol Volume: 103(5) Issue: 5 Pages: 560-566
  • DOI: 10.1007/s12185-016-1954-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with fondaparinux (2016)
  • Author(s): Ikejiri M, Wada H, Yamaguchi T, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Sakaguchi A, Matsumoto T, Ohishi K, Fujimoto N, Yamada N, Ito M, Katayama N, Sudo A
  • Journal Title: Int J Hematol Volume: 103 Issue: 5 Pages: 554-559
  • DOI: 10.1007/s12185-016-1963-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Presence of Antiphospholipid Antibodies as a Risk Factor for Thrombotic Events in Patients with Connective Tissue Diseases and Idiopathic Thrombocytopenic Purpura (2016)
  • Author(s): Habe K, Wada H, Matsumoto T, Ohishi K, Ikejiri M, Matsubara K, Morioka T, Kamimoto Y, Ikeda T, Katayama N, Mizutani H
  • Journal Title: Internal Medicine Volume: 55 Issue: 6 Pages: 589-595
  • DOI: 10.2169/internalmedicine.55.5536
  • NAID: 130005138059
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Infective Endocarditis Caused by Panton-Valentine Leukocidin-producing Methicillin-susceptible <i>Staphylococcus aureus</i> Identified by the Broad-range PCR Method (2016)
  • Author(s): Nakajima H, Dohi K, Tanabe M, Nakamura A, Kanemitsu S, Wada H, Yamada N, Nobori T, Shinpo H, Ito M
  • Journal Title: Internal Medicine Volume: 55 Issue: 14 Pages: 1871-1875
  • DOI: 10.2169/internalmedicine.55.5403
  • NAID: 130005165000
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antithrombin supplementation and risk of bleeding in patients with sepsis-associated disseminated intravascular coagulation (2016)
  • Author(s): Iba T, Gando S, Saitoh D, Wada H, Di Nisio M, Thachil J.
  • Journal Title: Thrombosis Research Volume: 145 Pages: 46-50
  • DOI: 10.1016/j.thromres.2016.07.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Revision of the Japanese Association for Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) diagnostic criteria using antithrombin activity. (2016)
  • Author(s): Iba T, Di Nisio M, Thachil J, Wada H, Asakura H, Sato K, Kitamura N, Saitoh D
  • Journal Title: .Crit Care Volume: 20 Issue: 1 Pages: 287-287
  • DOI: 10.1186/s13054-016-1468-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The valuable diagnosis of DIC and pre-DIC and prediction of a poor outcome by the evaluation of diagnostic criteria for DIC in patients with hematopoietic injury established by the Japanese Society of Thrombosis and Hemostasis (2016)
  • Author(s): Aota T, Wada H, Fujimoto N, Sugimoto K, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Kawasugi K, Madoiwa S, Asakura H, Katayama N
  • Journal Title: Thromb Res Volume: 147 Pages: 80-84
  • DOI: 10.1016/j.thromres.2016.09.028
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Disease Recurrence After Early Discontinuation of Eculizumab in a Patient With Atypical Hemolytic Uremic Syndrome With Complement C3 I1157T Mutation. (2016)
  • Author(s): Toyoda, H., Wada, H., Miyata, T., Amano, K., Kihira, K., Iwamoto, S., Hirayama, M., Komada, Y.
  • Journal Title: J Pediatr Hematol Oncol Volume: 38 Issue: 3 Pages: e137-e139
  • DOI: 10.1097/mph.0000000000000505
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiovascular events occur independently of high on-aspirin platelet reactivity and residual COX-1 activity in stable cardiovascular patients (2016)
  • Author(s): Nagatsuka K, Miyata S, Kada A, Wada H, et al
  • Journal Title: Thromb Haemost Volume: 116 Issue: 08 Pages: 356-368
  • DOI: 10.1160/th15-11-0864
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Management of cancer-associated disseminated intravascular coagulation: guidance from the SSC of the ISTH: comment. . (2016)
  • Author(s): Wada H, Matsumoto T, Aota T, Yamashita Y, Suzuki K, Katayama N.:
  • Journal Title: J Thromb Haemost Volume: 14 Issue: 6 Pages: 1314-1315
  • DOI: 10.1111/jth.13297
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta-analysis of randomized controlled trials: comment. (2016)
  • Author(s): Wada H, Matsumoto T, Aota T, Imai H, Suzuki K, Katayama N
  • Journal Title: J Thromb Haemost Volume: 14 Issue: 11 Pages: 2308-2309
  • DOI: 10.1111/jth.13394
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Shock, acute disseminated intravascular coagulation, and microvascular thrombosis: is 'shock liver' the unrecognized provocateur of ischemic limb necrosis: comment. (2016)
  • Author(s): Wada H, Matsumoto T, Fujimoto N, Imai H, Suzuki K, Katayama N
  • Journal Title: J Thromb Haemost. Volume: 14 Pages: 2315-2316
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with fondaparinux. (2016)
  • Author(s): Ikejiri M, Wada H, Yamaguchi T, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Sakaguchi A, Matsumoto T, Ohishi K, Fujimoto N, Yamada N, Ito M, Katayama N, Sudo A
  • Journal Title: Int J Hematol Volume: 103 Pages: 554-559
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fibrin related markers for diagnosing acute or chronic venous thromboembolism in patients with major orthopedic surgery. (2016)
  • Author(s): Yamaguchi T, Wada H, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Katayama N, Sudo A
  • Journal Title: Int J Hematol Volume: 103 Pages: 560-566
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The efficacy of the administration of recombinant human soluble thrombomodulin in patients with DIC (2015)
  • Author(s): Aota T, Wada H, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Katayama N
  • Journal Title: Int J Hematol Volume: 103 Issue: 2 Pages: 173-179
  • DOI: 10.1007/s12185-015-1899-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Antithrombin or thrombomodulin administration in severe pneumonia patients with sepsis and disseminated intravascular coagulation: comment on two papers. (2015)
  • Author(s): Wada H, Aota T, Matsumoto T, Suzuki K, Imai H, Katayama N
  • Journal Title: J Thromb Haemost Volume: 13 Issue: 4 Pages: 684-685
  • DOI: 10.1111/jth.12856
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Antithrombin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study: comment (2015)
  • Author(s): Aota T, Matsumoto T, Suzuki K, Imai H, Katayama N, Wada H
  • Journal Title: J Thromb Haemost Volume: 13 Issue: 4 Pages: 679-680
  • DOI: 10.1111/jth.12822
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 教育講演：新DIC診断基準の評価とDIC診断の問題点 (2018)
  • Author(s): 和田英夫
  • Organizer: 第19回日本検査血液学会学術集会
  • Invited
• [Presentation] 教育講演：血栓・出血のバイオマーカー (2018)
  • Author(s): 和田英夫
  • Organizer: 第58回日本臨床化学会年次学術集会
  • Invited
• [Presentation] Symposium： Diagnosis of DIC in accordance with APTT waveform, Clinical laboratory testing provides protection for patients (2018)
  • Author(s): Wada H
  • Organizer: The 10th Congress of Asia Pacific Society on Thrombosis and Haemostasis
  • Int'l Joint Research / Invited
• [Presentation] フォンダパリヌクスならびにエドキサバン投与患者の抗Xa活性によるモニター (2018)
  • Author(s): 和田英夫、池尻 誠、松本剛史
  • Organizer: 第12回日本血栓止血学会学術標準化委員会シンポジウム
• [Presentation] 抗Xa活性ならびにAPTT波形によるDOACのモニター (2018)
  • Author(s): 和田英夫、池尻 誠、松本剛史
  • Organizer: 第12回日本血栓止血学会学術標準化委員会シンポジウム
• [Presentation] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant (2017)
  • Author(s): Wada H, Matsumoto T, Ikejiri M, Sudo A
  • Organizer: XXVIth ISTH Congress
  • Int'l Joint Research
• [Presentation] An evaluation of the activated partial thromboplastin time waveform. (2017)
  • Author(s): Matsumoto T, Wada H, Ohishi K, Katayama N
  • Organizer: XXVIth ISTH Congress
  • Int'l Joint Research
• [Presentation] 血栓症/出血マーカーー、シンポジウム「臨床検査の最新知見」 (2017)
  • Author(s): 和田英夫
  • Organizer: 第56回 日本臨床検査医学会東海・北陸支部総会第334回 日本臨床化学会東海・北陸支部例会
  • Invited
• [Presentation] Natural history of disseminated intravascular coagulation. JSLH/ISLH Joint symposium 1: Disseminated intravascular coagulation (DIC) (2017)
  • Author(s): Wada H
  • Organizer: 第18回日本検査血液学会学術集会
  • Invited
• [Presentation] Guide for managing TTP and aHUS (2016)
  • Author(s): Hideo Wada
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-13
  • Invited
• [Presentation] Monitoring the hemostatic state in orthopedic surgery patients using fibrin related markers (2016)
  • Author(s): Wada H
  • Organizer: The 9th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis,
  • Place of Presentation: Taipei (Taiwan)
  • Year and Date: 2016-10-06
  • Int'l Joint Research / Invited
• [Presentation] Diagnosis and treatment of DIC (2016)
  • Author(s): Wada H
  • Organizer: The 33rd World Congress of Internal Medicine (WCIM Bali 2016)
  • Place of Presentation: Bali (Indonesia)
  • Year and Date: 2016-08-22
  • Int'l Joint Research / Invited
• [Presentation] 悪性腫瘍と静脈血栓塞栓症、悪性腫瘍に合併する血栓止血異常 (2016)
  • Author(s): 和田英夫
  • Organizer: 第17回日本検査血液学会
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-08-06
  • Invited
• [Presentation] 止血系マーカーによる過凝固（前血栓）状態の検討 (2016)
  • Author(s): 和田英夫
  • Organizer: 第38回日本血栓止血学会学術集会
  • Place of Presentation: 奈良春日野国際フォーラム (奈良県・奈良市）
  • Year and Date: 2016-06-16
  • Invited
• [Presentation] Elevated soluble platelet glycoprotein VI levels in patients after living donor liver transplantation (2015)
  • Author(s): Matsumoto T, Takahashi T, Usui M, Naitoh K, Wada H, Ohishi K, Katayama N, Isaji I
  • Organizer: XXVth ISTH Congress
  • Place of Presentation: Tronto (Canada)
  • Year and Date: 2015-06-20
  • Int'l Joint Research
• [Presentation] 日本血栓止血学会DIC診断基準暫定案検討 (2015)
  • Author(s): 和田英夫
  • Organizer: 第37回日本血栓止血学会学術集会
  • Place of Presentation: 甲府市総合市民会館(山梨県・甲府市
  • Year and Date: 2015-05-21
  • Invited
• [Book] 病気がみえる改訂2版。血液 (2017)
  • Author(s): 伊豆津宏二、神田善伸、後藤明彦、和田英夫、増田亜希子、松村譲じ、鈴木隆浩、岡田 賢、朝倉英策、室井一男監修
  • Total Pages: 290
  • Publisher: メディックメディア
  • ISBN: 9784896326529