Examination of prethrombotic state to prevent thrombosis
Project/Area Number |
15K08645
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | Mie University |
Principal Investigator |
Wada Hideo 三重大学, 医学系研究科, 准教授 (40158704)
|
Project Period (FY) |
2015-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 前血栓症 / 止血系マーカー / 遺伝子異常 / TMA / VTE / DIC / APTT波形 / D-dimer / 抗Xa活性 / 遺伝子解析 / aHUS / SF / thrombotic state / 遺伝子変異 / 補体 / PE / DVT / diagnosis / prediction |
Outline of Final Research Achievements |
Various hemostatic markers were significantly increased or decreased. The cutoff value of D-dimer and SF were determined to diagnose or predict thrombosis. AT, PC or PS abnormalities were frequently diagnosed by genetic analysis in VTE patients and the polymorphism of Fibrinogen αchain were significantly higher in female infertility than in healthy pregnant women. In Kinki area, C3I1157T variant was detected in 14 cases of aHUS patients. Several carrier who had genetic variant, had no symptom. The diagnostic criteria established by Japanese Society of Thrombosis and Hemostasis using AT, TAT, SF and decreased platelet count was significantly more useful than other diagnostic criteria for diagnosing DIC or Pre-DIC.
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Academic Significance and Societal Importance of the Research Achievements |
前血栓症状態を定義すれば、血栓症発症前診断が可能になる。血栓症発症前に抗血栓薬の予防投与を行えば、生命予後ならびに患者のQOLの改善につながる。また、血栓症発症を防ぐことにより、医療費を大幅に削減することができる。 本研究により、遺伝子診断が普及し、止血分子マーカーのカットオフ値が確立されると、早期の血栓症ならびに前血栓症状態の診断が普及し、容易になる。
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Report
(5 results)
Research Products
(56 results)
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[Journal Article] Congenital Thrombophilia in Patients With Superior Mesenteric Venous Thrombosis or Portal Vein Thrombosis.2018
Author(s)
Ikejiri M, Usui M, Wada H, Matsumoto T, Ohishi K, Shindo A, Yamashita Y, Nakatani K, Tamaki S, Tomimoto H, Isaji S
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Journal Title
Clin Appl Thromb Hemost
Volume: 24
Issue: 7
Pages: 1117-1121
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical manifestation of patients with atypical hemolytic uremic syndrome with the C3 p.I1157T variation in the Kinki region of Japan.2018
Author(s)
Matsumoto T, Toyoda H, Amano K, Hirayama M, Ishikawa E, Fujimoto M, Ito M, Ohishi K, Katayama N, Yoshida Y, Matsumoto M, Kawamura N, Ikejiri M, Kawakami K, Miyata T, Wada H
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Journal Title
Clin Appl Thromb Hemost
Volume: 24
Issue: 8
Pages: 1301-1307
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The evaluation of D-dimer levels for the comparison of fibrinogen and fibrin units using different D-dimer kits to diagnose VTE2018
Author(s)
Hasegawa M, Wada H, Yamaguchi T, Wakabayashi H, Fujimoto N, Matsumoto T, Hasegawa K, Yamada N, Ito M, Yamashita Y, Katayama N, Nakatani K, Sudo A
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Journal Title
Clin Appl Thromb Hemost
Volume: 24
Issue: 4
Pages: 655-662
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Monitoring of hemostatic abnormalities in major orthopedic surgery patients treated with edoxaban by APTT waveform2018
Author(s)
Hasegawa M, Wada H, Tone S, Yamaguchi T, Wakabayashi H, Ikejiri M, Watanabe M, Fujimoto N, Matsumoto T, Ohishi K, Yamashita Y, Katayama N, Sudo A
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Journal Title
Int J Lab Hematol
Volume: 40
Issue: 1
Pages: 49-55
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Platelet Activation Assessed by Glycoprotein VI/Platelet Ratio Is Associated With Portal Vein Thrombosis After Hepatectomy and Splenectomy in Patients With Liver Cirrhosis.2018
Author(s)
Matsui T, Usui M, Wada H, Iizawa Y, Kato H, Tanemura A, Murata Y, Kuriyama N, Kishiwada M, Mizuno S, Sakurai H, Isaji S
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Journal Title
Clin Appl Thromb Hemost.
Volume: 24
Issue: 2
Pages: 254-262
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] An Evaluation of Hemostatic Abnormalities in Patients With Hemophilia According to the Activated Partial Thromboplastin Time Waveform.2018
Author(s)
Katayama H, Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Habe K, Katayama N:
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Journal Title
Clin Appl Thromb Hemost
Volume: open ac
Issue: 7
Pages: 1170-1176
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] High prevalence of congenital thrombophilia in patients with pregnancy-related or idiopathic venous thromboembolism/pulmonary embolism.2017
Author(s)
Ikejiri M, Wada H, Yamada N, Nakamura M, Fujimoto N, Nakatani K, Matsuda A, Ogihara Y, Matsumoto T, Kamimoto Y, Ikeda T, Katayama N, Ito M
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Journal Title
Int J Hematol
Volume: 105
Issue: 3
Pages: 272-279
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Attempt to Harvest a Sufficient Number of Mononuclear Cells in an Appropriate Blood Product Volume By Modification of the Default Apheresis Setting.2017
Author(s)
Tanaka Y, Ohishi K, Sawai T, Iwasaki H, Kageyama S, Masuya M, Matsumoto T, Tanigawa T, Wada H, Shiku H, Ito M, Katayama N
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Journal Title
Ther Apher Dial.
Volume: 21
Issue: 5
Pages: 507-511
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] An Evaluation of the Activated Partial Thromboplastin Time Waveform2017
Author(s)
Matsumoto T, Wada H, Fujimoto N, Toyoda J, Abe Y, Ohishi K, Yamashita Y, Ikejiri M, Hasegawa K, Suzuki K, Imai H, Nakatani K, Katayama N
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Journal Title
Clin Appl Thromb Hemost
Volume: Epub
Issue: 5
Pages: 764-770
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with direct oral anticoagulant.2017
Author(s)
Ikejiri M, Wada H, Tone S, Wakabayashi H, Hasegawa M, Matsumoto T, Fujimoto N, Yamada N, Ito M, Nakatani K, Sudo A .
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Journal Title
Thromb J
Volume: open ac
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Plasma Levels of ADAMTS-13, von Willebrand Factor, VWFpp, and Fibrin-Related Markers in Patients With Systemic Sclerosis Having Thrombosis2017
Author(s)
Habe K, Wada H, Higashiyama A, Akeda T, Tsuda K, Mori R, Kakeda M, Matsumoto T, Ohishi K, Yamanaka K, Katayama N, Mizutani H.
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Journal Title
Clin Appl Thromb Hemost
Volume: 23
Issue: 6
Pages: 622-630
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants.: Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) 2017 in Japan.2017
Author(s)
Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M;
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Journal Title
Int J Hematol
Volume: 106
Issue: 1
Pages: 3-15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hypofibrinogenemia and the α-Fibrinogen Thr312Ala Polymorphism may be Risk Factors for Early Pregnancy Loss.2017
Author(s)
Kamimoto Y, Wada H, Ikejiri M, Nakatani K, Sugiyama T, Osato K, Murabayashi N, Habe K, Mizutani H, Matsumoto T, Ohishi K, Ikeda T
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Journal Title
Clin Appl Thromb Hemost
Volume: 23
Issue: 1
Pages: 52-57
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Evaluation of the Diagnostic Criteria for the Basic Type of DIC Established by the Japanese Society of Thrombosis and Hemostasis.2017
Author(s)
Aota T, Wada H, Fujimoto N, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Uchiyama T, Seki Y, Katayama N.
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Journal Title
Clin Appl Thromb Hemost.
Volume: 印刷中
Issue: 7
Pages: 579-584
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The Evaluation of Fibrin-Related Markers for Diagnosing or Predicting Acute or Subclinical Venous Thromboembolism in Patients Undergoing Major Orthopedic Surgery.2016
Author(s)
Hasegawa M, Wada H, Miyazaki S, Yamaguchi T, Wakabayashi H, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Yamashita Y, Katayama N, Nakatani K, Sudo A
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Journal Title
Clin Appl Thromb Hemost
Volume: -
Issue: 1
Pages: 107-114
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Supportive management strategies for disseminated intravascular coagulation-An international consensus,2016
Author(s)
Squizzato A, Hunt BJ, Gary T. Kinasewitz GT, Wada H, ten Cate H, Thachil J, Levi M, Vicente V, Angelo AD, Di Nisio M
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Journal Title
Thromb Haemost
Volume: 115
Issue: 05
Pages: 896-904
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Fibrin-related markers for diagnosing acute-, subclinical-,and pre-venous thromboembolism in patients with major orthopedic surgery.2016
Author(s)
Yamaguchi T, Wada H, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Yamashita Y, Katayama N, Sudo A.
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Journal Title
Int J Hematol
Volume: 103(5)
Issue: 5
Pages: 560-566
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with fondaparinux2016
Author(s)
Ikejiri M, Wada H, Yamaguchi T, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Sakaguchi A, Matsumoto T, Ohishi K, Fujimoto N, Yamada N, Ito M, Katayama N, Sudo A
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Journal Title
Int J Hematol
Volume: 103
Issue: 5
Pages: 554-559
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Presence of Antiphospholipid Antibodies as a Risk Factor for Thrombotic Events in Patients with Connective Tissue Diseases and Idiopathic Thrombocytopenic Purpura2016
Author(s)
Habe K, Wada H, Matsumoto T, Ohishi K, Ikejiri M, Matsubara K, Morioka T, Kamimoto Y, Ikeda T, Katayama N, Mizutani H
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Journal Title
Internal Medicine
Volume: 55
Issue: 6
Pages: 589-595
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Infective Endocarditis Caused by Panton-Valentine Leukocidin-producing Methicillin-susceptible <i>Staphylococcus aureus</i> Identified by the Broad-range PCR Method2016
Author(s)
Nakajima H, Dohi K, Tanabe M, Nakamura A, Kanemitsu S, Wada H, Yamada N, Nobori T, Shinpo H, Ito M
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Journal Title
Internal Medicine
Volume: 55
Issue: 14
Pages: 1871-1875
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The valuable diagnosis of DIC and pre-DIC and prediction of a poor outcome by the evaluation of diagnostic criteria for DIC in patients with hematopoietic injury established by the Japanese Society of Thrombosis and Hemostasis2016
Author(s)
Aota T, Wada H, Fujimoto N, Sugimoto K, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Kawasugi K, Madoiwa S, Asakura H, Katayama N
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Journal Title
Thromb Res
Volume: 147
Pages: 80-84
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Disease Recurrence After Early Discontinuation of Eculizumab in a Patient With Atypical Hemolytic Uremic Syndrome With Complement C3 I1157T Mutation.2016
Author(s)
Toyoda, H., Wada, H., Miyata, T., Amano, K., Kihira, K., Iwamoto, S., Hirayama, M., Komada, Y.
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Journal Title
J Pediatr Hematol Oncol
Volume: 38
Issue: 3
Pages: e137-e139
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Comparison of three different anti-Xa assays in major orthopedic surgery patients treated with fondaparinux.2016
Author(s)
Ikejiri M, Wada H, Yamaguchi T, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Sakaguchi A, Matsumoto T, Ohishi K, Fujimoto N, Yamada N, Ito M, Katayama N, Sudo A
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Journal Title
Int J Hematol
Volume: 103
Pages: 554-559
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Fibrin related markers for diagnosing acute or chronic venous thromboembolism in patients with major orthopedic surgery.2016
Author(s)
Yamaguchi T, Wada H, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, Fujimoto N, Matsumoto T, Ohishi K, Sakaguchi A, Yamada N, Ito M, Katayama N, Sudo A
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Journal Title
Int J Hematol
Volume: 103
Pages: 560-566
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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