Study of liver stiffness evaluation using ultrasound for follow-up observation and hepatocellular carcinoma carcinogenesis prediction in chronic liver disease.
| Project/Area Number |
15K08656
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
Osakabe Keisuke 藤田医科大学, 保健学研究科, 准教授 (30290167)
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| Co-Investigator(Kenkyū-buntansha) |
吉岡 健太郎 藤田医科大学, 医学部, 教授 (60201852)
橋本 千樹 藤田医科大学, 医学部, 准教授 (60378049)
川部 直人 藤田医科大学, 医学部, 准教授 (90410729)
西川 徹 藤田医科大学, 医学研究科, 研究員 (20410714)
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| Research Collaborator |
ICHINO Naohiro
SUGIYAMA Hiroko
ASADA Wakana
TAKAHASHI Ayako
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 線維化評価 / 慢性肝炎 / 肝硬変 / 治療効果 / 肝細胞癌 / 肝線維化 / 経過観察 / 線維化 / HCV / HBV |
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| Outline of Final Research Achievements |
The purpose of this study is to examine the usefulness of liver stiffness measurement (LSM) in the diagnosis of fibrosis and follow-up of treatment in chronic liver disease, and the usefulness of carcinogenesis prediction of hepatocellular carcinoma.
LSM was equivalent to fibrosis assessment using pathological tissue. In addition, the results of the follow-up examination reflected the treatment effect. Furthermore, LSM was also suggested to be a factor contributing to the prediction of carcinogenesis of hepatocellular carcinoma.
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| Academic Significance and Societal Importance of the Research Achievements |
超音波を用いた肝硬度測定は、病理組織による肝線維化評価と比較すると、各線維化ステージと相関しており、さらにカットオフ値の設定も可能であった。また経過観察での検討でも治療群では経過に伴い肝硬度値が改善するなど治療効果を反映した結果であった。一方、治療を行っていない群では、肝硬度は変化することはなく、高値化する症例も存在した。さらに肝硬度による肝細胞癌の発癌予測の検討では、肝硬度の高値化は発癌に寄与する因子の一つであることが示唆された。以上のことより、非侵襲的に検査を行える超音波を用いた肝硬度測定法は、慢性肝疾患の各種診断に有用であることが示された。
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Report
(5 results)
Research Products
(20 results)
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[Presentation] Reduction of shear-wave velocity by antiviral therapy in chronic hepatitis B2018
Author(s)
Keisuke Osakabe, Naohiro Ichino, Toru Nishikawa, Hiroko Sugiyama, Wakana Asada, Ayako Takahashi, Kana Mametani, Takuji Nakano, Kazunori Nakaoka, Masashi Ohki, Sayuri Nomura, Tomoki Takamura, Naoto Kawabe, Senju Hashimoto and Kentaro Yoshioka.
Organizer
Asian Pacific Association for the Study of the Liver Single Topic Conference 2018
Related Report
Int'l Joint Research
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[Presentation] Non-invasive Assessment of Hepatic Fibrosis in Nonalcoholic Fatty Liver Disease2018
Author(s)
Naohiro Ichino, Keisuke Osakabe, Toru Nishikawa, Hiroko Sugiyama, Wakana Asada, Ayako Takahashi, Kana Mametani, Takuji Nakano, Kazunori Nakaoka, Masashi Ohki, Sayuri Nomura, Tomoki Takamura, Naoto Kawabe, Senju Hashimoto and Kentaro Yoshioka.
Organizer
Asian Pacific Association for the Study of the Liver Single Topic Conference 2018
Related Report
Int'l Joint Research
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