| Project/Area Number |
15K08657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 量基 関西医科大学, 医学部, 准教授 (70434826)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Tリンパ球由来マイクロパーティクル / OX40L / Th2 反応性 / TSLP / 樹状細胞 / フォスファチジルセリン / LFA-1 / Th2反応 / ICAM-1 / プロテインキナーゼC / MAPキナーゼ |
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| Outline of Final Research Achievements |
The thymic stromal lymphopoietin (TSLP)-dendritic cell (DC)-OX40L axis is the principal pathway in the inflammatory cascades in allergic diseases. Microparticles (MPs) are small membrane vesicles released from many different cell types by exocytotic budding of the plasma membrane in response to cellular activation or apoptosis. We focused on the ability of T-lymphocyte-derived MPs (TLMPs) to promote OX40L-mediated Th2 responses. Although most TLMPs contain PS, few express LFA-1. TLMP remarkably enhanced TSLP-DC-driven or OX40L-driven Th2 responses from naive T cells and the Th2 functional attributes of CRT+ CD4+ Th2 memory cells by the increased production of IL-5, IL-9 and IL-13. TLMP functions as a positive regulator of the TSLP-DC-OX40L axis that initiates and maintains Th2 cell-mediated inflammatory responses, and therefore, it might be a new therapeutic target for the treatment of allergic disorders.
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