Induction and maintenance of Th2 immune responses by T-lymphocyte-derived microparticle
| Project/Area Number |
15K08657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 量基 関西医科大学, 医学部, 准教授 (70434826)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Tリンパ球由来マイクロパーティクル / OX40L / Th2 反応性 / TSLP / 樹状細胞 / フォスファチジルセリン / LFA-1 / Th2反応 / ICAM-1 / プロテインキナーゼC / MAPキナーゼ |
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| Outline of Final Research Achievements |
The thymic stromal lymphopoietin (TSLP)-dendritic cell (DC)-OX40L axis is the principal pathway in the inflammatory cascades in allergic diseases. Microparticles (MPs) are small membrane vesicles released from many different cell types by exocytotic budding of the plasma membrane in response to cellular activation or apoptosis. We focused on the ability of T-lymphocyte-derived MPs (TLMPs) to promote OX40L-mediated Th2 responses. Although most TLMPs contain PS, few express LFA-1. TLMP remarkably enhanced TSLP-DC-driven or OX40L-driven Th2 responses from naive T cells and the Th2 functional attributes of CRT+ CD4+ Th2 memory cells by the increased production of IL-5, IL-9 and IL-13. TLMP functions as a positive regulator of the TSLP-DC-OX40L axis that initiates and maintains Th2 cell-mediated inflammatory responses, and therefore, it might be a new therapeutic target for the treatment of allergic disorders.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Tyrosine kinase inhibitor and rituximab-CHOP treatment for concurrent chronic myeloid leukemia and non-Hodgkin lymphoma: a case report.2017
Author(s)
Takeyasu Y, Satake A, Azuma Y, Tsubokura Y, Yoshimura H, Hotta M, Nakanishi T, Fujita S, Nakaya A, Ito T, Nomura S.
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Journal Title
Clinical Case Reports
Volume: 5
Pages: 2047-2050
Related Report
Peer Reviewed
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[Journal Article] Phase I/II study of erlotinib, carboplatin, pemetrexed, and bevacizumab in chemotherapy-na?ve patients with advanced non-squamous non-small cell lung cancer harboring epidermal growth factor receptor mutation.2017
Author(s)
Kurata T, Nakaya A, Yokoi T, Niki M, Kibata K, Takeyasu Y, Torii Y, Katashiba Y, Ogata M, Miyara T, Nomura S.
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Journal Title
Genes, chromosomes & cancer
Volume: 8
Issue: 5-6
Pages: 559-565
DOI
Related Report
Peer Reviewed
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[Journal Article] Delayed HBV reactivation in rituximab-containing chemotherapy: How long should we continue anti-virus prophylaxis or monitoring HBV-DNA?2016
Author(s)
Nakaya A, Fujita S, Satake A, Nakanishi T, Azuma Y, Tsubokura Y, Hotta M, Yoshimura H, Ishii K, Ito T, Nomura S
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Journal Title
Leukemia Research
Volume: 50
Pages: 46-49
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Enhanced international prognostic index in Japanese patients with diffuse large B-cell lymphoma.2016
Author(s)
Nakaya A, Fujita S, Satake A, Nakanishi T, Azuma Y, Tsubokura Y, Hotta M, Yoshimura H, Ishii K, Ito T, Nomura S
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Journal Title
Leukemia Research Report
Volume: 6
Pages: 24-26
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Guanosine and its modified derivatives are endogenous ligands for TLR72015
Author(s)
Shibata T, Ohto U, Nomura S, Kibata K, Motoi Y, Zhang Y, Murakami Y, Fukui R, Ishimoto T, Sano S, Ito T, Shimizu T, Miyake K
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Journal Title
International Immunology
Volume: In press
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[Presentation] Clinical impact of mogamulizumab against aggressive adult T cell leukemia/lymphoma : a single-center retrospective analysis2017
Author(s)
Atsushi Satake, Yoshiko Azuma, Yukie Tsubokura, Hideaki Yoshimura, Masaaki Hotta, Takahisa Nakanishi, Shinya Fujita, Aya Nakaya, Michihiko Miyaji, Tomoki Ito, Kazuyoshi Ishii, Shosaku Nomura
Organizer
59th ASH Annual Meeting & Exposition
Related Report
Int'l Joint Research
