Diagnostic procedure and treatment of late recurrence and tumor dormancy
| Project/Area Number |
15K08659
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本田 一文 国立研究開発法人国立がん研究センター, 研究所, ユニット長 (10260936)
菊池 正二郎 兵庫医科大学, 医学部, 准教授 (70381960)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | がん間質 / 線維芽細胞 / 休眠 / がん免疫 / 間質細胞 / 老化間質細胞 / がん間質細胞 / 胃がん晩期再発 / 老化細胞 / SASP / エクソソーム |
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| Outline of Final Research Achievements |
We isolated cancer-associated fibroblast and normal fibroblast from advanced gastric cancer tissue. VEGF isoform and CCL2, which were secreted from fibroblasts, were concerned with a clinical course of gastric cancer patients. We performed a clinical study (UMIN 000017123) for relapsed or metastatic gastric cancer patients. It became clear that CCL2/CCR2 axis inhibition by Propagermanium improved overall survival to participate in immunopotentiative effects and tumor dormancy.
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Report
(4 results)
Research Products
(3 results)
