Establishment of clinical and pathological evaluation method of NETs
| Project/Area Number |
15K08660
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
炬口 真理子 姫路獨協大学, 薬学部, 准教授 (10379430)
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| Research Collaborator |
KONO Mari シスメックス株式会社, 学術推進部
HIRAMATSU Yasushi 姫路赤十字病院, 血液腫瘍内科, 部長
YAMAMOTO Mitsuteru バークレー動物病院, 院長
OKAMURA Akiharu 加古川中央市民病院, 病理部
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 好中球 / 細胞外トラップ / ヘミン / デフェラシロクス / アセテート / 自動血球計数装置 / 酸化ストレス / へミン / エンドトキシン / シトルリン化ヒストン / フローサイトメトリー |
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| Outline of Final Research Achievements |
Neutrophil extracellular traps are related to tissue damage, sepsis, thrombosis, cancer metastasis, and arteriosclerosis in addition to
antibacterial activity. We have studied the effect of hemin on NET producing effects. Hemin induced NETs in a short period, and that was enhanced by the presence of oxidative stress. Deferasirox and acetate inhibited NET formation. Neutrophil activation, prerequisite for NET, was quantitatively detectable by using automated hematology analyzer. These results help the understanding of NET biology and provide a possible clinical detection method.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Iron chelating agent, Deferasirox, inhibits neutrophil activation and extracellular trap (NET) formation.2016
Author(s)
Mari Kono, Katsuyasu Saigo, Shiori Yamamoto, Kohei Shirai, Shuta Iwamoto, Tomoko Uematsu, Takayuki Takahashi, Shion Imoto, Makoto Hashimoto, Yosuke Minami, Atsushi Wada, Mariko Takenokuchi, Seiji Kawano
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Journal Title
Clinical and Experimental Pharmacology and Physiology
Volume: 43
Pages: 915-920
Related Report
Peer Reviewed / Int'l Joint Research
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