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Methadone-used new therapy for morphine-resistant intractable pain

Research Project

Project/Area Number 15K08678
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionTohoku Medical and Pharmaceutical University

Principal Investigator

Mizoguchi Hirokazu  東北医科薬科大学, 薬学部, 教授 (30360069)

Co-Investigator(Kenkyū-buntansha) 桜田 忍  東北医科薬科大学, 薬学部, 客員教授 (30075816)
渡辺 千寿子  東北医科薬科大学, 薬学部, 准教授 (90296020)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords多発性硬化症疼痛 / 難治性疼痛 / Morphine / Methadone / NMDA受容体
Outline of Final Research Achievements

The analgesic effect of morphine is reduced in the condition of sciatic nerve ligation-induced neuropathic pain, inflammatory pain and multiple sclerosis-related pain. In the present study, we found that the single injection of methadone recovered the reduced morphine analgesia observed in those morphine-resistant intractable pain through a blockade of NMDA receptor.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (28 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (18 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Neuropharmacological properties of the essential oil of bergamot for the clinical management of pain-related BPSDs2018

    • Author(s)
      Damiana Scuteri, Laura Rombola, Laura Tridico, Hirokazu Mizoguchi, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada, Maria Tiziana Corasanit, Giacinto Bagetta, Luigi Antonio Morrone
    • Journal Title

      Current Medicinal Chemistry

      Volume: 印刷中 Issue: 20 Pages: 3764-3774

    • DOI

      10.2174/0929867325666180307115546

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine.2017

    • Author(s)
      Mizoguchi H, Watanabe C, Hayashi T, Iwata Y, Watanabe H, Katsuyama S, Hamamura K, Sakurada T, Ohtsu H, Yanai K, Sakurada S.
    • Journal Title

      European Journal of Pharmacology

      Volume: 800 Pages: 9-15

    • DOI

      10.1016/j.ejphar.2017.01.031

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bergamot essential oil attenuates anxiety-like behaviour in rats2017

    • Author(s)
      Laura Rombola, Laura Tridico, Damiana Scuteri, Tsukasa Sakurada, Shinobu Sakurada, Hirokazu Mizoguchi, Pinarosa Avato, Maria Tiziana Corasaniti, Giacinto Bagetta, Luigi Antonio Morrone
    • Journal Title

      Molecules

      Volume: 22 Issue: 4 Pages: 614-614

    • DOI

      10.3390/molecules22040614

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Opioids resistance in chronic pain management2017

    • Author(s)
      Luigi A. Morrone, Damiana Scuteri, Laura Rombola, Hirokazu Mizoguchi, Giacinto Bagetta
    • Journal Title

      Current Neuropharmacology

      Volume: 15 Issue: 3 Pages: 444-456

    • DOI

      10.2174/1570159x14666161101092822

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analgesic Effects of 1st Generation Anti-histamines in Mice2016

    • Author(s)
      Mebae Takahashi, Kazuhiro Shima, Masahiro Tsuchiya, Yoshihiro Hagiwara, Hirokazu Mizoguchi, Shinobu Sakurada, Shunji Sugawara, Takuo Fujita, Takeshi Tadano, Makoto Watanabe, Satoshi Fukumoto, Yasuo Endo
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 39 Issue: 4 Pages: 620-624

    • DOI

      10.1248/bpb.b15-00755

    • NAID

      130005141684

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intrathecal morphine-3-glucuronide-induced nociceptive behavior via δ-2 opioid receptors in the spinal cord2016

    • Author(s)
      Takaaki Komatsu, Soh Katsuyama, Hiroshi Nagase, Hirokazu Mizoguchi, Chikai Sakurada, Minoru Tsuzuki, Shinobu Sakurada, Tsukasa Sakurada
    • Journal Title

      Pharmacology Biochemistry & Behavior

      Volume: 140 Pages: 68-74

    • DOI

      10.1016/j.pbb.2015.10.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Involvement of spinal glutamate in nociceptive behavior induced by intrathecal administration of hemokinin-1 in mice2016

    • Author(s)
      Chizuko Watanabe, Hirokazu Mizoguchi, Giacinto Bagetta, Shinobu Sakurada
    • Journal Title

      Neuroscience Letters

      Volume: 617 Pages: 236-239

    • DOI

      10.1016/j.neulet.2016.02.027

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 依存性のない新規鎮痛薬の探索2018

    • Author(s)
      溝口広一
    • Organizer
      第2回仙台痛みフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 天然由来成分の抗かゆみ活性2018

    • Author(s)
      芦部文一朗、松見繁、丸山徹也、溝口広一、櫻田忍
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症性疼痛下における各種麻薬性鎮痛薬における鎮痛効果とその耐性形成能2017

    • Author(s)
      込山麻美、溝口広一、渡辺千寿子、音羽亮、櫻田忍
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 多発性硬化症疼痛に対する麻薬性鎮痛薬の効果2017

    • Author(s)
      溝口広一、渡辺千寿子、音羽亮、櫻田忍
    • Organizer
      平成29年度東北医科薬科大学創薬研究センターシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症性疼痛下における麻薬性鎮痛薬の鎮痛効果ならびに鎮痛耐性形成2017

    • Author(s)
      込山麻美、渡辺千寿子、音羽亮、櫻田忍、溝口広一
    • Organizer
      平成29年度東北医科薬科大学創薬研究センターシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Amidino-TAPAの神経障害性疼痛に対する有効性2017

    • Author(s)
      溝口広一、渡辺千寿子、音羽亮、櫻田忍
    • Organizer
      第4回包括的緩和医療科学学術研究会・第5回Tokyo疼痛緩和次世代研究会合同研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effectiveness of amidino-TAPA against morphine-resistant neuropathic pain2017

    • Author(s)
      Hirokazu Mizoguchi、Chizuko Watanabe、Akira Otowa、Shinobu Sakurada
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 難治性掻痒症治療薬nalfurafineの末梢性抗掻痒作用2017

    • Author(s)
      音羽亮、渡辺千寿子、長瀬博、櫻田忍、溝口広一
    • Organizer
      第68回日本薬理学会北部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症性疼痛制御におけるmethadoneの特異的作用2017

    • Author(s)
      込山麻美、渡辺千寿子、音羽亮、櫻田忍、溝口広一
    • Organizer
      第68回日本薬理学会北部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 炎症性疼痛下における各種麻薬性鎮痛薬の鎮痛効果とその耐性形成能2016

    • Author(s)
      込山麻美、溝口広一、渡辺千寿子、音羽亮、櫻田忍
    • Organizer
      第67回日本薬理学会北部会
    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 神経障害性疼痛に対する麻薬性鎮痛薬ならびに新規鎮痛薬の効果2016

    • Author(s)
      溝口広一、渡辺千寿子、音羽亮、櫻田忍
    • Organizer
      平成28年度東北医科薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      東北医科薬科大学(宮城県・仙台市)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Research-status Report
  • [Presentation] 炎症性疼痛下における各種麻薬性鎮痛薬の鎮痛効果とその耐性形成能2016

    • Author(s)
      込山麻美、溝口広一、渡辺千寿子、音羽亮、櫻田忍
    • Organizer
      平成28年度東北医科薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      東北医科薬科大学(宮城県・仙台市)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Research-status Report
  • [Presentation] Nalfurafineの末梢性抗掻痒作用2016

    • Author(s)
      音羽亮、溝口広一、渡辺千寿子、長瀬博、櫻田忍
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Hemokinin-1誘発性疼痛関連行動の発現機構2016

    • Author(s)
      渡辺千寿子、溝口広一、音羽亮、櫻田忍
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Amidino-TAPAの非依存性に関わるμオピオイド受容体スプライスバリアントの探索2016

    • Author(s)
      溝口広一、渡辺千寿子、音羽亮、吉岡麻也、櫻田忍
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 多発性硬化症疼痛に対するオピオイド性鎮痛薬の効果2015

    • Author(s)
      溝口広一、渡辺千寿子、音羽亮、長瀬博、櫻田忍
    • Organizer
      第9回日本緩和医療薬学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Amidino-TAPAの非依存性に関わるμオピオイド受容体スプライスバリアントの探索2015

    • Author(s)
      溝口広一、渡辺千寿子、音羽亮、吉岡麻也、櫻田忍
    • Organizer
      第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 難治性掻痒症治療薬nalfurafineの末梢性抗掻痒作用2015

    • Author(s)
      音羽亮、小笠原蓉子、新井田隆宏、溝口広一、渡辺千寿子、勝山壮、長瀬博、櫻田忍
    • Organizer
      第66回日本薬理学会北部会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Book] トワイクロス先生の緩和ケア処方薬 第2版2017

    • Author(s)
      武田 文和、鈴木勉 監訳
    • Total Pages
      887
    • Publisher
      医学書院
    • ISBN
      9784260030311
    • Related Report
      2017 Annual Research Report
  • [Book] 疾患薬理学2016

    • Author(s)
      溝口広一
    • Total Pages
      862
    • Publisher
      Neo Medical
    • Related Report
      2015 Research-status Report
  • [Book] Aromatherapy: Basic Mechanisms and Evidence Based Clinical Use2015

    • Author(s)
      Laura Rombola, Luigi Antonio Morrone, Chizuko Watanabe, Hirokazu Mizoguchi, Tsukasa Sakurada, Laura Berliocchi, Maria Tiziana Corasaniti, Giacinto Bagetta, and Shinobu Sakurada
    • Total Pages
      461
    • Publisher
      CRC Press
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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