Role of gastrointestinal hormone in itch of atopic dermatitis

• Project/Area Number: 15K08680
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Juntendo University
• Principal Investigator: TOMINAGA MITSUTOSHI 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (50468592)
• Co-Investigator(Kenkyū-buntansha): 鎌田 弥生 順天堂大学, 医学(系)研究科(研究院), 研究員(移行) (00410035) ; 高森 建二 順天堂大学, 医学部, 特任教授 (40053144)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: アロネーシス / 脊髄後角 / 後根神経節 / コレシストキニン / ドライスキン / かゆみ過敏 / アトピー性皮膚炎

Outline of Final Research Achievements

This study was performed to reveal the role of cholecystokinin (CCK), a　gastrointestinal hormone, in itch associated with atopic dermatitis. Pharmacologically, our behavioral analyses showed that intrathecal injection of sulfated CCK8 (CCK8S) induced alloknesis via the spinal CCK2 receptor (CCKR2). Thus, we developed a model of alloknesis, and these data suggest that the CCK8S/CCK2R system is involved in induction of alloknesis in mice.

Academic Significance and Societal Importance of the Research Achievements

かゆみと掻破の悪循環を引き起こすアロネーシスの本態に迫る研究成果と、それに基づく治療法の開発が期待される。

Research Products

• [Journal Article] Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms. (2017)
  • Author(s): Otsu A, Kawasaki H, Tominaga M, Shigenaga A, Matsuda H, Takahashi N, Nakajima T, Naito H, Baba T, Ogawa H, Tomooka Y, Yamakura F, Takamori K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 485 Issue: 4 Pages: 707-712
  • DOI: 10.1016/j.bbrc.2017.02.109
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy of an emollient containing diethylene glycol/dilinoleic acid copolymer for the treatment of dry skin and pruritus in patients with senile xerosis. (2017)
  • Author(s): Izumi R, Negi O, Suzuki T, Tominaga M, Kamo A, Suga Y, Matsukuma S, Takamori K.
  • Journal Title: J Cosmet Dermatol. Volume: 印刷中 Issue: 4 Pages: 197-204
  • DOI: 10.1111/jocd.12332
  • Peer Reviewed / Open Access
• [Journal Article] A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus (2017)
  • Author(s): Komiya, E. Hatano, R. Otsuka, H. Itoh, T. Yamazaki, H. Yamada, T. Dang, N. H. Tominaga, M. Suga, Y. Kimura, U. Takamori, K. Morimoto, C. Ohnuma, K.
  • Journal Title: J Dermatol Sci Volume: 印刷中 Issue: 3 Pages: 212-221
  • DOI: 10.1016/j.jdermsci.2017.03.005
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin (2017)
  • Author(s): Sakaguchi A, Kamata Y, Takahashi N, Matsuda H, Kosaka R, Umehara Y, Ogawa H, Tominaga M, Takamori K
  • Journal Title: Clinical and Experimental Dermatology Volume: 42 Issue: 8 Pages: 890-894
  • DOI: 10.1111/ced.13207
  • Peer Reviewed
• [Journal Article] Involvement of μ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice (2017)
  • Author(s): Takahashi N, Tominaga M, Kosaka R, Kamata Y, Umehara Y, Matsuda H, Sakaguchi A, Ogawa H, Takamori K
  • Journal Title: Acta Dermato Venereologica Volume: 97 Issue: 8 Pages: 928-933
  • DOI: 10.2340/00015555-2704
  • Peer Reviewed
• [Journal Article] Oral administration of milk-derived phospholipids inhibits a penetration of cutaneous nerve fibers into epidermis in an acute dry skin model mouse. (2017)
  • Author(s): Sakaguchi A, Kamata Y, Takahashi N, Matsuda H, Kosaka R, Umehara Y, Ogawa H, Tominaga M, Takamori K.
  • Journal Title: Clin Exp Dermatol Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice. (2016)
  • Author(s): Atsushi Noguchi, Mitsutoshi Tominaga, Nobuaki Takahashi, Hironori Matsuda, Yayoi Kamata, Yoshie Umehara, Ko Kyi Chan, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
  • Journal Title: J Dermatol Sci Volume: 86 Issue: 1 Pages: 54-62
  • DOI: 10.1016/j.jdermsci.2016.12.015
  • Peer Reviewed
• [Journal Article] Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. (2016)
  • Author(s): Kamata Y, Kimura U, Matsuda H, Tengara S, Kamo A, Umehara Y, Iizumi K, Kawasaki H, Suga Y, Ogawa H, Tominaga M, Takamori K.
  • Journal Title: J Dermatol Sci Volume: 84 Issue: 3 Pages: 266-271
  • DOI: 10.1016/j.jdermsci.2016.09.009
  • Peer Reviewed
• [Journal Article] Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission. (2016)
  • Author(s): Kusube F ,Tominaga M, Kawasaki H, Yamakura F, Naito H, Ogawa H, Tomooka Y, Takamori K,
  • Journal Title: Neuroscience Letters Volume: 627 Pages: 51-60
  • DOI: 10.1016/j.neulet.2016.05.051
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intrathecal minocycline suppresses itch-related behavior and improves dermatitis in atopic dermatitis model mouse. (2016)
  • Author(s): Torigoe K, Tominaga M, Ko KC, Takahashi N, Matsuda H, Hayashi R, Ogawa H, Takamori K.
  • Journal Title: J Invest Dermatol Volume: 136 Issue: 4 Pages: 879-881
  • DOI: 10.1016/j.jid.2015.12.037
  • Peer Reviewed
• [Journal Article] Neurotropin suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms. (2016)
  • Author(s): Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K.
  • Journal Title: J Dermatol Sci Volume: 81 Issue: 3 Pages: 212-215
  • DOI: 10.1016/j.jdermsci.2015.11.014
  • Peer Reviewed
• [Journal Article] Possible anti-pruritic mechanisms of cyclosporine A in atopic dermatitis. (2016)
  • Author(s): Ko KC, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K.
  • Journal Title: Acta Derm Venereol Volume: 未定 Issue: 5 Pages: 624-629
  • DOI: 10.2340/00015555-2318
  • Peer Reviewed / Open Access
• [Journal Article] Cathelicidin LL-37 induces semaphorin 3A production in human epidermal keratinocytes: implications for possible application to pruritus. (2015)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K.
  • Journal Title: J Invest Dermatol Volume: 135 Issue: 11 Pages: 2887-2890
  • DOI: 10.1038/jid.2015.243
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Retinoid-related orphan receptor alpha is involved in induction of semaphorin 3A expression in normal human epidermal keratinocytes (2015)
  • Author(s): Yayoi Kamata, Mitsutoshi Tominaga, Azumi Sakaguchi, Yoshie Umehara, Osamu Negi, Hideoki Ogawa, Kenji Takamori
  • Journal Title: J Dermatol Sci Volume: 印刷中 Issue: 1 Pages: 84-86
  • DOI: 10.1016/j.jdermsci.2015.03.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Topical application of Tenshino-softgelTM reduces epidermal nerve fiber density in a chronic dry skin model mouse. (2015)
  • Author(s): Noguchi A, Tominaga M, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K.
  • Journal Title: Journal of Cosmetics, Dermatological Sciences and Applications Volume: 5 Issue: 04 Pages: 254-261
  • DOI: 10.4236/jcdsa.2015.54031
  • Peer Reviewed / Open Access
• [Presentation] 痒みのメカニズム: 痒みを伴う皮膚疾患の病態解析最新情報. (2017)
  • Author(s): 冨永光俊.
  • Organizer: 第116回日本皮膚科学会総会, 仙台, 2017年6月2日
  • Invited
• [Presentation] 痒みのメカニズム―痒みを伴う皮膚疾患の病態解析最新情報―. (2017)
  • Author(s): 冨永光俊.
  • Organizer: 第13回Tokyo scientific forum for AtopicDermatitis and Psoriasis (TAP), 東京, 2017年12月2日
  • Invited
• [Presentation] An overview of treatment for opiodi-induced itch. ) (2017)
  • Author(s): Takamori K, Takahashi N, Tominaga M.
  • Organizer: 9th World Congress on Itch, Wroclaw, Poland, October 15-17, 2017 (Plenary session
  • Int'l Joint Research / Invited
• [Presentation] Sulfated CCK8 induces alloknesis via spinal CCK2 receptor in mice. (2017)
  • Author(s): Tominaga M, Kusube F, Honda K, Takahashi N, Naito H, Yamakura F, Ogawa H, Tomooka Y, Takamori K.
  • Organizer: 9th World Congress on Itch, Wroclaw, Poland, October 15-17, 2017 (Plenary session)
  • Int'l Joint Research
• [Presentation] Possible role of satellite glial cell derived lipocalin-2 in the pathogenesis of atopic dermatitis. (2017)
  • Author(s): Takahashi N, Tominaga M, Kosaka R, Matsuda H, Suga Y, Takamori K.
  • Organizer: 9th World Congress on Itch, Wroclaw, Poland, October 15-17, 2017 (Concurrent session)
  • Int'l Joint Research
• [Presentation] Involvement of spinal microglia in the pathogenesis of imiquimod-induced psoriasis-like dermatitis model mice. (2017)
  • Author(s): Kosaka R, Tominaga M, Takahashi N, Toyama S, Ogawa H, Nishiyama C, Takamori K.
  • Organizer: 9th World Congress on Itch, Wroclaw, Poland, October 15-17, 2017 (Poster session)
  • Int'l Joint Research
• [Presentation] The regulation of pruritus in psoriasis and atopic dermatitis-a possible role for CD26/DPPIV. (2017)
  • Author(s): Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Suga Y, Kimura U, Tominaga M, Takamori K, Ohnuma K, Morimoto C.
  • Organizer: 9th World Congress on Itch, Wroclaw, Poland, October 15-17, 2017 (Morning session)
  • Int'l Joint Research
• [Presentation] Relationship between pruritus and serum lipocalin-2 in patients with psoriasis. (2017)
  • Author(s): Aizawa N, Ishiuji Y, Inokuchi S, Yanaba K, Umezawa Y, Asahina A, Takahashi N,Tominaga M, Takamori K, Nakagawa H.
  • Organizer: 9th World Congress on Itch, Wroclaw, Poland, October 15-17, 2017 (Poster session)
  • Int'l Joint Research
• [Presentation] Plasma granzyme B level is promising clinical maker for itch severity in the patients with atopic dermatitis. (2017)
  • Author(s): Kamata Y, Kimura U, Matsuda H, Tengara S, Suga Y, Tominaga M, Takamori K.
  • Organizer: 第27回国際痒みシンポジウム, 2017年11月11日 (口頭発表)
• [Presentation] 乳由来リン脂質の経口投与は急性ドライスキンモデルマウスにおける表皮内神経線維の増生を抑制する. (2017)
  • Author(s): 坂口安澄、鎌田弥生、高橋伸明、松田浩則、幸坂涼平、梅原芳恵、須賀 康、冨永光俊、髙森建二.
  • Organizer: 第47回日本皮膚アレルギー・接触皮膚炎学会総会学術大会, 鹿児島 (かごしま県民交流センター), 2017年12月8日(金)～10日(日) (口頭発表)
• [Presentation] Intrathecal injection of sulfated cholecystokinin-8 induces alloknesis in mice. (2017)
  • Author(s): Tominaga M, Kusube F, Honda K, Takahashi N, Naito H, Yamakura F, Suga Y, Ogawa H, Tomooka Y, Takamori K.
  • Organizer: 第42回日本研究皮膚科学会, 高知市文化プラザかるぽーと, 高知, 2017年12月15日～17日(ポスター発表)
• [Presentation] Involvement of satellite glial cell derived lipocalin-2 in the pathogenesis of NC/Nga mice with atopic dermatitis-like symptoms. (2017)
  • Author(s): Takahashi N, Tominaga M, Kosaka R, Matsuda H, Suga Y, Ogawa H, Takamori K.
  • Organizer: 第42回日本研究皮膚科学会, 高知市文化プラザかるぽーと, 高知, 2017年12月15日～17日(ポスター発表)
• [Presentation] Calcium increases semaphorin 3A expression by activating PKC/MAPK/AP-1 signaling axis in normal human epidermal keratinocytes. (2017)
  • Author(s): Kamata Y, Umehara Y, Sakaguchi A, Suga Y, Ogawa H, Tominaga M, Takamori K.
  • Organizer: 第42回日本研究皮膚科学会, 高知市文化プラザかるぽーと, 高知, 2017年12月15日～17日(ポスター発表)
• [Presentation] A method to differentiate peripheral neurons from human induced pluripotent stem cells for the development of treatment for intractable itch. (2017)
  • Author(s): Umehara Y, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Ogawa H, Takamori K.
  • Organizer: 第42回日本研究皮膚科学会, 高知市文化プラザかるぽーと, 高知, 2017年12月15日～17日(ポスター発表)
• [Presentation] Regulatory T cells modulate skin inflammation in atopic dermatitis model mouse. (2017)
  • Author(s): Toyama S, Matsuda H, Kosaka R, Ogawa H, Tominaga M, Takamori K.
  • Organizer: 第42回日本研究皮膚科学会, 高知市文化プラザかるぽーと, 高知, 2017年12月15日～17日(ポスター発表)
• [Presentation] Electrophysiological characterization of nalfurafine-responsive dorsal horn neurons in spinal itch transmission. (2017)
  • Author(s): Honda K, Tominaga M, Kusube F, Yamakura F, Naito H, Suga Y, Ogawa H, Takamori K.
  • Organizer: 第42回日本研究皮膚科学会, 高知市文化プラザかるぽーと, 高知, 2017年12月15日～17日(口頭発表、Concurrent session)
• [Presentation] CD26/DPPIV regulates mechanical itch in a mechanistically distinct manner from chemical itch. (2017)
  • Author(s): Komiya E, Hatano R, Otsuk H, Itoh T, Yamazaki H, Tominaga M, Takamori K, Ohnuma K, Morimoto C.
  • Organizer: 第42回日本研究皮膚科学会, 高知市文化プラザかるぽーと, 高知, 2017年12月15日～17日(口頭発表、Concurrent session)
• [Presentation] 痒みのメカニズムと治療展望―特に、アトピー性皮膚炎について―. (2017)
  • Author(s): 冨永光俊
  • Organizer: 第14回順天堂眼アレルギー研究会
  • Place of Presentation: ホテル東京ガーデンパレス（東京）
  • Invited
• [Presentation] アトピー性皮膚炎、なぜかゆい？ (2016)
  • Author(s): 冨永光俊、高森建二.
  • Organizer: 第46回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2016-11-05
  • Invited
• [Presentation] Roles of brain-natriuretic peptide- and gastrin-releasing peptide-responsive neurons in spinal transmission of itch. (2016)
  • Author(s): Kusube Y, Tominaga M, Kawasaki H, Yamakura F, Naito H, Ogawa H, Tomooka Y, Takamori K.
  • Organizer: 46th Annual Meeting of the European Society for Dermatological Research (ESDR)
  • Place of Presentation: Technical University of Munich (Munich, Germany)
  • Year and Date: 2016-09-07
  • Int'l Joint Research
• [Presentation] Efficacy of kappa-opioid receptor agonist and mu-opioid receptor antagonist to treat itch in imiquimod-induced psoriasis-like dermatitis model. (2016)
  • Author(s): Takahashi, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Ogawa H, Takamori K.
  • Organizer: 46th Annual Meeting of the European Society for Dermatological Research (ESDR)
  • Place of Presentation: Technical University of Munich (Munich, Germany)
  • Year and Date: 2016-09-07
  • Int'l Joint Research
• [Presentation] An analgesic agent suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms. (2016)
  • Author(s): Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K.
  • Organizer: 46th Annual Meeting of the European Society for Dermatological Research (ESDR)
  • Place of Presentation: Technical University of Munich (Munich, Germany)
  • Year and Date: 2016-09-07
  • Int'l Joint Research
• [Presentation] A role of spinal glial cells in pruritus of atopic dermatitis model mouse. (2016)
  • Author(s): Tominaga M, Torigoe K, Ogawa H, Takamori K.
  • Organizer: 46th Annual Meeting of the European Society for Dermatological Research (ESDR)
  • Place of Presentation: Technical University of Munich (Munich, Germany)
  • Year and Date: 2016-09-07
  • Int'l Joint Research
• [Presentation] Studies on a novel biomarker for atopic dermatitis. (2016)
  • Author(s): Iizumi K, Kawasaki H, Tominaga M, Shigenaga A, Kamo A, Kamata Y, Takamori K, Yamakura F.
  • Organizer: 16th IUBMB CONFERENCE
  • Place of Presentation: Vancouver Convention Centre (Canada)
  • Year and Date: 2016-07-17
  • Int'l Joint Research
• [Presentation] 難治性かゆみのメカニズムと制御―皮膚から脊髄まで―. (2016)
  • Author(s): 冨永光俊、高森建二.
  • Organizer: 第26回国際痒みシンポジウム
  • Place of Presentation: エーザイ本社（東京）
  • Invited
• [Presentation] Electrophysiological characterization of BNP- and GRP-responsive dorsal horn neurons in spinal itch transmission. (2015)
  • Author(s): Tominaga M, Kusube F, Kawasaki H, Yamakura F, Naito H, Ogawa H, Tomooka Y, Takamori K.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] Inhibitory factors in semaphorin 3A expression of human epidermal keratinocytes. (2015)
  • Author(s): Kamata Y, Umehara Y, Tominaga M, Negi O, Ogawa H, Takamori K.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] Effects of antimicrobial peptides on expression of axon guidance molecules in normal human epidermal keratinocytes. (2015)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] Host defense protein S100A7/psoriasin regulates pores in the epidermis: aquaporins and tight junctions. (2015)
  • Author(s): Hattori F, Ikeda S, Okumura K, Tominaga M, Takamori K, Ogawa H, Okamoto K, Niyonsaba F.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] ヒト表皮角化細胞を用いたセマフォリン3A 遺伝子の近位プロモーター領域の解析. (2015)
  • Author(s): 鎌田弥生、冨永光俊、梅原芳恵、高森建二.
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド (神戸)
  • Year and Date: 2015-12-01
• [Presentation] ヒトiPS細胞からのかゆみ末梢神経誘導法の開発. (2015)
  • Author(s): 梅原芳恵、冨永光俊、松田浩則、鎌田弥生、髙森建二.
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド (神戸)
  • Year and Date: 2015-12-01
• [Presentation] H1-ヒスタミン受容体拮抗薬による軸索ガイダンス分子の発現調節作用. (2015)
  • Author(s): 鎌田弥生、坂口安澄、梅原芳恵、冨永光俊、小川秀興、高森建二.
  • Organizer: 第45回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 島根県民会館（島根）
  • Year and Date: 2015-11-20
• [Presentation] 抗菌ペプ チドLL-37は培養正常ヒト表皮角化細胞における神経反発因子semaphorin 3Aの発現を促進する. (2015)
  • Author(s): 梅原芳恵、鎌田弥生、冨永光俊、Francois Niyonsaba、小川秀興、高森建二.
  • Organizer: 第45回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 島根県民会館（島根）
  • Year and Date: 2015-11-20
• [Book] Atopic dermatitis: Pruritus Second Edition. (2016)
  • Author(s): Tominaga M, Takamori K.
  • Total Pages: 453
  • Publisher: Springer Science+Business Media
• [Book] Itch in atopic dermatitis management. Curr Probl Dermatol. (2016)
  • Author(s): Kamata Y, Tominaga M, Takamori K.
  • Total Pages: 209
  • Publisher: Karger
• [Book] Pruritus Second Edition (2016)
  • Author(s): Tominaga M, Takamori K.
  • Publisher: Springer Science+Business Media
• [Book] Itch-Management in Clinical Practice (2016)
  • Author(s): Kamata Y, Tominaga M, Takamori K.
  • Publisher: Medical and Scientific Publishers
• [Remarks] 順天堂大学大学院医学研究科環境医学研究所 高森建二研究グループ
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/k4_takamori.html
• [Remarks] かゆみと真剣勝負、かゆみの克服を目指して！
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/kayumi/
• [Remarks] 順天堂大学大学院医学研究科環境医学研究所 高森建二グループ
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/k4_takamori.html
• [Patent(Industrial Property Rights)] 掻痒性皮膚疾患の予防又は治療薬 (2018)
  • Inventor(s): 楠部史也、冨永光俊、高森建二.
  • Industrial Property Rights Holder: 楠部史也、冨永光俊、高森建二.
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-028908
  • Filing Date: 2018
  • Overseas