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Pain and itch perception in humans using neuroimaging methods

Research Project

Project/Area Number 15K08685
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

KAKIGI Ryusuke  生理学研究所, システム脳科学研究領域, 教授 (10145196)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords痛み / かゆみ / 脳波 / 脳磁図 / MRI / 痛覚 / 機能的MRI / 痒み / 触覚 / 経頭蓋磁気刺激
Outline of Final Research Achievements

The main research objective was to clarify the cognitive mechanism of nociception and itch in human brain using various non-invasive measurement methods. During the study period, I published many articles on pain and itch and many new treatments, and was introduced in many media such as newspapers, television and radio. In 2018,I published "Guidelines on the clinical application of MEG (magnetoencephalography)" by co-authoring with famous MEG researchers from around the world. I wrote mainly on "pain and itch perception". It is published in the top journal of this field, and a number of citations are expected as a guide for future MEG studies. I am highly regarded internationally and have made special lectures at many international conferences.

Academic Significance and Societal Importance of the Research Achievements

ヒトにおける痛みとかゆみの脳内認知機構に関する研究者は少なく、国内はもとより、海外においても、研究成果は高く評価され注目されてきた。これまではほとんど解明されていなかった痛みとかゆみの認知機構を詳細に解析し、私たちが、なぜ、どのようにして、痛みとかゆみを感じるのかを明らかにした。また、治療が困難な痛みとかゆみについて、新たな治療法を報告し、高い注目を集めている。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (35 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (17 results) (of which Int'l Joint Research: 7 results,  Invited: 17 results) Book (2 results) Remarks (3 results)

  • [Journal Article] IFCN-endorsed practical guidelines for clinical magnetoencephalography (MEG)2018

    • Author(s)
      Hari Riitta、Baillet Sylvain、Barnes Gareth、Burgess Richard、Forss Nina、Gross Joachim、Hamalainen Matti、Jensen Ole、Kakigi Ryusuke、Mauguiere Francois、Nakasato Nobukatzu、Puce Aina、Romani Gian-Luca、Schnitzler Alfons、Taulu Samu
    • Journal Title

      Clinical Neurophysiology

      Volume: 129 Issue: 8 Pages: 1720-1747

    • DOI

      10.1016/j.clinph.2018.03.042

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 痒みを想像すると痒くなるメカニズム2018

    • Author(s)
      望月秀紀、柿木隆介
    • Journal Title

      神経内科

      Volume: 89 Pages: 62-68

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarity-independent effects of transcranial direct current stimulation over the bilateral opercular somatosensory region: a magnetoencephalography study.2017

    • Author(s)
      Nakagawa K, Koyama S, Inui K, Tanaka S, Kakigi R, Sadato N
    • Journal Title

      NeuroReport

      Volume: 28 Issue: 13 Pages: 822-827

    • DOI

      10.1097/wnr.0000000000000845

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] かゆみと痛みの脳内認知機構2017

    • Author(s)
      望月秀紀、柿木隆介
    • Journal Title

      日本臨床

      Volume: 75 Pages: 334-343

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A transcranial direct current stimulation over the sensorimotor cortex modulates the itch sensation induced by histamine2016

    • Author(s)
      Nakagawa K., Mochizuki H., Koyama S., Tanaka S., Sadato N., Kakigi R
    • Journal Title

      Clinical Neurophysiology

      Volume: 127 Issue: 1 Pages: 827-832

    • DOI

      10.1016/j.clinph.2015.07.003

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] かゆみの脳内認知機構2016

    • Author(s)
      望月秀紀、柿木隆介
    • Journal Title

      脊髄外科

      Volume: 30 Pages: 53-57

    • NAID

      130005163535

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] ヒトにおける痛覚の脳内認知機構2016

    • Author(s)
      柿木隆介
    • Journal Title

      臨床評価

      Volume: 43 Pages: 516-522

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Journal Article] Investigation of the Cerebral Cortex Using Magnetoencephalography(MEG)2015

    • Author(s)
      柿木隆介
    • Journal Title

      BRAIN and NERVE

      Volume: 67 Issue: 4 Pages: 451-466

    • DOI

      10.11477/mf.1416200162

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2015-04-01
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Temporal dynamics of neural activity in motor execution and inhibition processing2015

    • Author(s)
      Nakata H, Sakamoto K, Kakigi R
    • Journal Title

      Neuroscience Letters

      Volume: 594 Pages: 82-86

    • DOI

      10.1016/j.neulet.2015.03.055

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central mechanisms of itch2015

    • Author(s)
      Mochizuki H, Kakigi R
    • Journal Title

      Clinical Neurophysiology

      Volume: 126 Issue: 9 Pages: 1650-1660

    • DOI

      10.1016/j.clinph.2014.11.019

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Itch and brain2015

    • Author(s)
      Mochizuki H, Kakigi R
    • Journal Title

      Journal of Dermatology

      Volume: 42 Issue: 8 Pages: 761-767

    • DOI

      10.1111/1346-8138.12956

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 運動による除痛効果2015

    • Author(s)
      中田大貴、柿木隆介
    • Journal Title

      ペインクリニック

      Volume: 36 Pages: 592-600

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 神経イメージング手法を用いた痛みの脳内認知機構の解明 -特に運動による除痛効果について-2015

    • Author(s)
      柿木隆介
    • Journal Title

      Practice of Pain Management

      Volume: 6 Pages: 49-53

    • Related Report
      2015 Research-status Report
  • [Presentation] Itch perception in humans2019

    • Author(s)
      Kakigi R
    • Organizer
      Second meeting of the Egyptian Clinical Neurophysiology Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Itch perception in humans2018

    • Author(s)
      Kakigi R
    • Organizer
      31st International Congress of Clinical Neurophysiology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 痒みと痛みの脳内認知機構2018

    • Author(s)
      柿木隆介
    • Organizer
      名古屋大学予防早期医療創成センター第7回ワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] かゆみと痛みの脳内認知機構2018

    • Author(s)
      柿木隆介
    • Organizer
      第十回「痛みを考える会」特別講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ich perception in humans2017

    • Author(s)
      Kakigi R
    • Organizer
      The 6th Asia-Oceanian Congress of Clinical Neurophysiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Pain perception in humans.2017

    • Author(s)
      Kakigi R
    • Organizer
      The 6th Asia-Oceanian Congress of Clinical Neurophysiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトにおける痒みの脳内認知機構2017

    • Author(s)
      柿木隆介
    • Organizer
      第7回名古屋大学医学系研究科・生理学研究所 合同シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 痒みと痛みの脳内認知機構2017

    • Author(s)
      柿木隆介
    • Organizer
      第28回ペインクリニック学会東海地方会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 「痒みと痛みの脳内認知機構」と「咀嚼が脳活動に及ぼす影響」2017

    • Author(s)
      柿木隆介
    • Organizer
      第39回与五沢矯正研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Pain and itch perception in humans.2016

    • Author(s)
      Kakigi R
    • Organizer
      Satellite Symposium of 16thW World Congress of Pain
    • Place of Presentation
      Sheraton Miyako Hotel Tokyo, Minato-Ku, Tokyo, Japan
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Pain and itch perception in humans.2016

    • Author(s)
      Kakigi R
    • Organizer
      16th Scientific Meeting of Asian Academy of Craniomandibular Disorders
    • Place of Presentation
      神奈川県歯科医師会館、Yokohama, Kanagawa, Japan
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 痛みと痒みの脳内認知機構2015

    • Author(s)
      柿木隆介
    • Organizer
      第25回日本磁気歯科学会
    • Place of Presentation
      東京医科歯科大学、東京都文京区
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 痛みと痒みの脳内認知機構2015

    • Author(s)
      柿木隆介
    • Organizer
      第42回日本脳科学会
    • Place of Presentation
      ANAホリデイ・イン宮崎、宮崎県宮崎市
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 痛覚認知に影響する諸因子:運動、心理効果など2015

    • Author(s)
      柿木隆介
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場、富山県富山市
    • Year and Date
      2015-10-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Itch perception in humans2015

    • Author(s)
      Kakigi R, Mochizuki H
    • Organizer
      8th World Congress of Itch
    • Place of Presentation
      奈良春日野国際フォーラム、奈良県奈良市
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 痛みと痒みの脳内認知機構2015

    • Author(s)
      柿木隆介
    • Organizer
      第40回日本口腔外科学会中部支部学術集会
    • Place of Presentation
      岡崎市民病院、愛知県岡崎市
    • Year and Date
      2015-06-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 痛みと痒みのニューロモデュレーション2015

    • Author(s)
      柿木隆介
    • Organizer
      第29回日本ニューロモデュレーション学会
    • Place of Presentation
      都市センターホテル、東京都千代田区
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 世界にかゆいがなくなる日2017

    • Author(s)
      柿木隆介
    • Total Pages
      192
    • Publisher
      ナツメ社
    • ISBN
      4816363408
    • Related Report
      2017 Research-status Report
  • [Book] Clinical Applications of Magnetoencephalography2016

    • Author(s)
      Tobomatsu S, Kakigi R
    • Total Pages
      330
    • Publisher
      Springer, Japan
    • Related Report
      2015 Research-status Report
  • [Remarks] 自然科学研究機構生理学研究所システム脳科学研究領域統合生理研究部門

    • URL

      http://www.nips.ac.jp/smf/

    • Related Report
      2017 Research-status Report
  • [Remarks] 生理学研究所統合生理研究部門

    • URL

      http://www.nips.ac.jp/smf/

    • Related Report
      2016 Research-status Report
  • [Remarks] 非侵襲的大脳皮質刺激により痒み知覚が抑制される

    • URL

      http://www.nips.ac.jp/release/2015/08/_tdcs.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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