study on accuracy of biological effects and liner energy transfer in heavy ion therapy
| Project/Area Number |
15K08690
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Nagoya University (2017)
Gunma University (2015-2016) |
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Principal Investigator |
Hirano Yoshiyuki 名古屋大学, 医学系研究科(保健), 准教授 (00423129)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 炭素線治療 / モンテカルロシミュレーション / 生物線量 / CR39 / マイクロドシメトリー / MKモデル / 重粒子 / 生物効果モデル / LET分布 / 粒子線治療 / LETスペクトル / モンテカルロ法 / シミュレーション / Geant4-DNA |
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| Outline of Final Research Achievements |
In order to verify the accuracy of liner energy transfer (LET) and biological effect (survival rate) in heavy ion therapy, I conducted experiments and simulations as follows. To calculate the survival rate by cell irradiation and colony assay method, I made an automatic system to count number of colony and measure size of the colony which may suggested dependency of LET distribution on cellular growth. The system enabled us to measure survival rate with stability. The irradiation conditions (LET distribution, secondary particle content etc) of the cell were clarified by simulation. The simulation was verified by comparing with the experimental LET distribution in carbon irradiation with the CR39 detector. I also modified the MK (microdosimetric kinetic) model, which is a model to predict survival rate, giving flexibility to the model and enabling prediction of survival rate under various irradiation conditions.
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Report
(4 results)
Research Products
(7 results)
