Prediction of tumor control and side effects using in-treatment dose distribution in stereotactic body radiotherapy
| Project/Area Number |
15K08692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Imae Toshikazu 東京大学, 医学部附属病院, 主任診療放射線技師 (80420222)
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| Co-Investigator(Kenkyū-buntansha) |
山下 英臣 東京大学, 医学部附属病院, 講師 (70447407)
芳賀 昭弘 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (30448021)
辰己 大作 医療法人新明会都島放射線科クリニック(放射線治療研究開発部), 放射線治療研究開発部, 医学物理士 (60728848)
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| Research Collaborator |
WATANABE Yuichi 東京大学, 医学部附属病院, 診療放射線技師 (30772876)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 体幹部定位放射線治療 / 強度変調回転照射法 / 対象内構造 / 実線量分布 / 腫瘍制御 / 副作用 / 予測法 / 治療中 / 強度変調放射線回転治療 / Flattening Filter Free / 放射線治療 / 定位 / 体幹部 / 強度変調法 / 回転型 / 線量分布 |
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| Outline of Final Research Achievements |
Stereotactic body radiotherapy (SBRT) with volumetric modulated arc therapy (VMAT) is an effective strategy to treat lung or prostate cancer. VMAT is a rotational intensity modulated radiotherapy technique capable of acquiring projection images during delivery. The purpose of this study was to reconstruct in-treatment dose distribution for SBRT by use of cone-beam CT (CBCT) and a log file during VMAT delivery and predict tumor control and side effects using in-treatment dose distribution. We evaluated in vivo dosimetry for prostate cancer using commercial software, developed a new method to reconstruct in-treatment dose distribution from in-treatment CBCT and a log file acquired during VMAT-SBRT and evaluated the safety and availability of VMAT-SBRT using flattening-filter-free (FFF) technique in treatment of lung cancer. VMAT-SBRT using FFF technique shortened the treatment time for lung SBRT while maintaining a high local control rate with low toxicity.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Evaluation of a Post-analysis Method for Cumulative Dose Distribution in Stereotactic Body Radiotherapy2016
Author(s)
今江 禄一, 芳賀 昭弘, 早乙女 直也, 木田 智士, 中野 正寛, 竹中 重治, 竹内 幸浩, 白木 尚, 矢野 敬一, 山下 英臣, 中川 恵一, 大友 邦
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Journal Title
Japanese Journal of Radiological Technology
Volume: 72
Issue: 3
Pages: 251-260
DOI
NAID
ISSN
0369-4305, 1881-4883
Related Report
Peer Reviewed / Open Access
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[Presentation] Dose Reconstruction for Prostate SBRT by Use of Cone-Beam CT and a Log File During FFF-VMAT Delivery.2017
Author(s)
T Imae, A Haga, Y Watanabe, S Takenaka, K Nawa, W Takahashi, H Yamashita, Y Takeuchi, K Yano, K Nakagawa, O Abe.
Organizer
The 59th Annual Meeting and Exhibition (AAPM)
Related Report
Int'l Joint Research
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