| Project/Area Number |
15K08692
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Imae Toshikazu 東京大学, 医学部附属病院, 主任診療放射線技師 (80420222)
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| Co-Investigator(Kenkyū-buntansha) |
山下 英臣 東京大学, 医学部附属病院, 講師 (70447407)
芳賀 昭弘 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (30448021)
辰己 大作 医療法人新明会都島放射線科クリニック(放射線治療研究開発部), 放射線治療研究開発部, 医学物理士 (60728848)
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| Research Collaborator |
WATANABE Yuichi 東京大学, 医学部附属病院, 診療放射線技師 (30772876)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 体幹部定位放射線治療 / 強度変調回転照射法 / 対象内構造 / 実線量分布 / 腫瘍制御 / 副作用 / 予測法 / 治療中 / 強度変調放射線回転治療 / Flattening Filter Free / 放射線治療 / 定位 / 体幹部 / 強度変調法 / 回転型 / 線量分布 |
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| Outline of Final Research Achievements |
Stereotactic body radiotherapy (SBRT) with volumetric modulated arc therapy (VMAT) is an effective strategy to treat lung or prostate cancer. VMAT is a rotational intensity modulated radiotherapy technique capable of acquiring projection images during delivery. The purpose of this study was to reconstruct in-treatment dose distribution for SBRT by use of cone-beam CT (CBCT) and a log file during VMAT delivery and predict tumor control and side effects using in-treatment dose distribution. We evaluated in vivo dosimetry for prostate cancer using commercial software, developed a new method to reconstruct in-treatment dose distribution from in-treatment CBCT and a log file acquired during VMAT-SBRT and evaluated the safety and availability of VMAT-SBRT using flattening-filter-free (FFF) technique in treatment of lung cancer. VMAT-SBRT using FFF technique shortened the treatment time for lung SBRT while maintaining a high local control rate with low toxicity.
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