| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Enlargement of the temporal horn of the lateral ventricle on CT images is an accurate diagnostic marker of Alzheimer's disease. We developed a z-score-based semi-quantitative analysis of the temporal horn volume of the lateral ventricle for detection of early Alzheimer's disease on CT images. The previous study showed that regional mean z score of the temporal horn of the lateral ventricle calculated using the method was highly correlated with the volume of the temporal horn of the lateral ventricle for 50 subjects (R2=0.94). Also, This scheme was applied to CT scans from 51 AD patients and 31 controls to evaluate the performance of the method for detecting Alzheimer's. The estimated temporal horn of the lateral ventricle volume was markedly increased in the Alzheimer's group compared with the controls (P < .0001). Therefore, this computerized method may have the potential to accurately detect early Alzheimer's on CT images.
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