Association between H. pylori infection and dental disease

• Project/Area Number: 15K08711
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokyo
• Principal Investigator: mizuno yoshiko 東京大学, 大学院医学系研究科(医学部), 特任研究員 (80436477)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ヘリコバクターピロリ菌 / 齲歯 / 歯周炎 / 胃十二指腸病変 / 齲歯、歯周炎 / 胃・十二指腸病変

Outline of Final Research Achievements

Helicobacter pylori (H. pylori) is a gram negative, microaerophilic, spiral-shaped bacterium found in the gastric mucosa. Infection with this organism causes peptic and duodenal ulcers, gastric carcinoma and non-Hodgkin's lymphomas of gastric mucosa-associated lymphoid tissue (MALT). Although approximately 50% of people in the world are infected with H. pylori, the route by which H. pylori infection is transmitted is not yet clear. One of the unanswered questions is whether oral cavities could be a reservoir of these bacteria. The aim of this study is to determine the relationship between H. pylori and dental caries/periodontitis focusing on cytotoxin-associated A (CagA)-positive H. pylori strains.

Academic Significance and Societal Importance of the Research Achievements

ピロリ菌の罹患率は、先進国では20-30%であり、除菌治療に成功しない限り感染者は生涯キャリアとなる。本邦では除菌治療の健康保険適用が「慢性胃炎」にまで改訂され、治療法は確立されているが、除菌の成功率は約90％である。また、一旦除菌に成功しても胃・十二指腸病変が再発する症例もあり、除菌治療後の成人におけるピロリ菌の再感染も否めない。本研究では齲歯、歯周炎がピロリ菌の病原巣となりうるかにつき、ピロリ感染と齲歯/歯周病の関連について解析した。

Research Products

• [Journal Article] Usefulness of carotid arterial strain values for evaluating the arteriosclerosis. (2019)
  • Author(s): Iino H, Okano T, Daimon M, Sasaki K, Chigira M, Nakao T, Mizuno Y, Yamazaki T, Kurano M, Yatomi Y, Sumi Y, Sasano T, Miyata T.
  • Journal Title: J Atheroscler Thromb. Volume: 26(5) Pages: 476-487
  • NAID: 130007641277
  • Peer Reviewed
• [Journal Article] Beneficial effect of body weight control on left ventricular diastolic function in the general population: an analysis of longitudinal data from a health check-up clinic. (2018)
  • Author(s): Lee SC, Daimon M, Di Tullio MR, Homma S, Hasegawa T, Chiou SH, Nakao T, Hirokawa M, Mizuno Y, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 19(2) Pages: 136-142
  • Peer Reviewed
• [Journal Article] Association of subclinical carotid atherosclerosis with immediate memory and other cognitive functions. (2018)
  • Author(s): Matsumoto L, Suzuki K, Mizuno Y, Ohike Y, Ozeki A, Ono S, Takanashi M, Sawaki D, Suzuki T, Yamazaki T, Tsuji S, Iwata A.
  • Journal Title: Geriatrics & Gerontology International Volume: 18(1) Pages: 65-71
  • Peer Reviewed
• [Journal Article] Relationship of left ventricular diastolic function to obesity and overweight in a japanese population with preserved left ventricular ejection fraction. (2016)
  • Author(s): 1.Lee SL, Daimon M, Di Tullio MR, Homma S, Nakao T, Kawata T, Kimura K, Shinozaki T, Hirokawa M, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: Circulation Journal Volume: 80(9) Pages: 1951-1956
  • NAID: 130005406872
  • Peer Reviewed
• [Journal Article] Factors influencing left atrial volume in a population with preserved ejection fraction: Left ventricular diastolic dysfunction or clinical factors? (2016)
  • Author(s): 2.Lee SL, Daimon M, Nakao T, Singer DE, Shinozaki T, Kawata T, Kimura K, Hirokawa M, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: Journal of Cardiology Volume: 68(4) Pages: 275-281
  • Peer Reviewed
• [Journal Article] Early menopause does not influence left ventricular diastolic dysfunction: A clinical observational study in healthy subjects. (2016)
  • Author(s): 3.Hirokawa M, Daimon M, Lee SL, Nakao T, Kawata T, Kimura K, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: Journal of Cardiology Volume: 68 Pages: 548-553
  • Peer Reviewed
• [Journal Article] 脳ドックの実際、心電図 (2016)
  • Author(s): 水野由子、山崎力
  • Journal Title: Clinical Neuroscience Volume: 34巻4号 Pages: 419-423
• [Journal Article] Early menopause does not influence left ventricular diastolic dysfunction: A clinical observational study in healthy subjects. (2016)
  • Author(s): 1.Hirokawa M, Daimon M, Lee SL, Nakao T, Kawata T, Kimura K, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: J Cardiol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Factors influencing left atrial volume in a population with preserved ejection fraction: Left ventricular diastolic dysfunction or clinical factors? (2016)
  • Author(s): Lee SL, Daimon M, Nakao T, Singer DE, Shinozaki T, Kawata T, Kimura K, Hirokawa M, Kato TS, Mizuno Y, Watanabe M, Yatomi Y, Yamazaki T, Komuro I.
  • Journal Title: J Cardiol. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 耐糖能異常が腫瘍マーカーに及ぼす影響について (2015)
  • Author(s): 水野由子、山崎力、小出大介、小室一成
  • Journal Title: 日本内科学会雑誌 Volume: 104(Suppl) Pages: 160-160
  • Peer Reviewed
• [Presentation] Lipoprotein(a) is associated with elevated mitral E/e’ ratio in Japanese non-Heart Failure population. (2019)
  • Author(s): Mizuno Y, Daimon M Uemura K, Ito H, Kiriyama H, Yoshida Y, Nakanishi K, Kaneko H, Koide D, Yamamichi N, Komuro I.
  • Organizer: American College of Cardiology
  • Int'l Joint Research
• [Presentation] Role of anemia and proteinuria in the development of renal function deterioration in general population with preserved glomerular filtration Rate. (2019)
  • Author(s): Kiriyama H, Kaneko H, Itoh H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yatomi Y, Komuro I.
  • Organizer: Japanese Circulation Society 第83回日本循環器学会学術集会
• [Presentation] Association between the updated blood pressure classification according to ACC/AHA guidelines and carotid intima-media thickness: A community-based cohort study. (2019)
  • Author(s): Itoh H, Kaneko H, Kiriyama H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yatomi Y, Komuro I.
  • Organizer: Japanese Circulation Society 第83回日本循環器学会学術集会
• [Presentation] Association of arterial stiffness with left atrial volume and function: A community-based cohort study (2019)
  • Author(s): Yoshida Y, Nakanishi K, Daimon M, Nakao T, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Mizuno Y, Morita H, Yatomi Y, Komuro I.
  • Organizer: Japanese Circulation Society 第83回日本循環器学会学術集会
• [Presentation] 人間ドック受診者における脂肪肝と脂質関連因子および動脈硬化の検討 (2018)
  • Author(s): 水野由子、小出大介、大門雅夫、山道信毅、小室一成
  • Organizer: 第5９回日本人間ドック学会学術大会
• [Presentation] 当センターで新たに診断された心房細動症例についての検討 (2017)
  • Author(s): 1.古川佳子、横山郁夫、松尾容子、水野由子、内野悠一、林田済、銭谷幹夫、天野隆弘
  • Organizer: 第58回日本人間ドック学会学術大会
• [Presentation] 耐糖能異常が腫瘍マーカーに及ぼす影響について (2015)
  • Author(s): 水野由子、山崎力、小出大介、小室一成
  • Organizer: 第112回日本内科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2015-04-10