Molecule epidemiology research on coffee intake relation polymorphisms and type 2 diabetes

• Project/Area Number: 15K08718
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Seinan Jo Gakuin University
• Principal Investigator: Yin Guang 西南女学院大学, 保健福祉学部, 准教授 (90444786)
• Co-Investigator(Kenkyū-buntansha): 内藤 真理子 名古屋大学, 医学系研究科, 准教授 (10378010)
• Co-Investigator(Renkei-kenkyūsha): Hamajima Nobuyuki 名古屋大学, 医学研究科医療行政学, 教授 (30172969)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 2型糖尿病 / コーヒー摂取 / 遺伝子多型 / 分子疫学 / 空腹時血糖値 / 飲酒

Outline of Final Research Achievements

In this research, we analyzed cross-sectional study using the data set of Japan Multi-Institutional Collaborative Cohort Study. This study subjects were includes 5151 person, aged 35-69 years of Nagoya city residence. In 2015-2016, we analyzed the relationship between ADH1B and ALDH2 gene polymorphism and the risk of type 2 diabetes, examined the interaction between these genetic polymorphisms, coffee intake and alcohol consumption, and compiled them in a paper (Yin G et al, Nagoya J Med Sci 78(2):183-93, 2016). In 2017, the experiments of candidate gene polymorphisms CYP1A2, PAPSS1, GRIN2A, CAB36L and LBMA4 related to coffee intake habits were completed and statistical analysis was made on the relationship between these polymorphisms and type 2 diabetes.

Research Products

• [Journal Article] Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. (2018)
  • Author(s): Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K
  • Journal Title: Gene Volume: 642 Pages: 172-177
  • Peer Reviewed / Open Access
• [Journal Article] ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men (2016)
  • Author(s): Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H
  • Journal Title: Nagoya J Med Sci. 2016 May;78(2):183-93. Volume: ７８ Pages: 183-193
  • NAID: 120005756085
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ALDH2 Polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men (2016)
  • Author(s): GUANG YIN, MARIKO NAITO, KENJI WAKAI, EMI MORITA, SAYO KAWAI, NOBUYUKI HAMAJIMA, SADAO SUZUKI, YOSHIKUNI KITA, TOSHIRO TAKEZAKI, KEITARO TANAKA, MAKIKO MORITA, HIROKAZU UEMURA, ETSUKO OZAKI, SATOYO HOSONO, HARUO MIKAMI, MICHIAKI KUBO, HIDEO TANAKA
  • Journal Title: Nzgoya J. Med.Sci Volume: 78 Pages: 183193-183193
  • NAID: 120005756085
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] がん罹患歴とPTPN11遺伝子多型（rs2301756)の関連：J-MICC Study 静岡地区 (2015)
  • Author(s): 川合紗世、銀光、須磨紫乃、岡田理恵子、菱田朝陽、内藤真理子、浜島信之、若井建志
  • Organizer: 第74回 日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-10-08