| Project/Area Number |
15K08719
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Okinaka Memorial Institute for Medical Research |
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Principal Investigator |
Hoshino Junichi (財)冲中記念成人病研究所, その他部局等, 研究員 (70725861)
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| Research Collaborator |
Fujii Takayuki
Usui Joichi
Tsunoda Ryoya
Takada Daisuke
Suzuki Satoshi
Takaichi Kenmei
Ubara Yoshifumi
Yamagata Kunihiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | IgA腎症 / 臨床疫学 |
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| Outline of Final Research Achievements |
In order to clarify appropriate treatment strategies in patients with immunoglobulin A nephropathy (IgAN), we established a new data collection system consists of multidisciplinary teams and have collected 1840 patients who diagnosed IgAN by renal biopsy from 4 hospitals.
The 10-year survival in IgAN patients has been improving by decades, which may be associated with the widespread of tonsillectomy plus steroid pulse therapy (TSP) in 2000s. Patients with TSP had better renal outcome than other therapies in patients with massive proteinuria (≧1.0 g/gCr), and similar finding was observed in CKDG4 patients with proteinuria≧0.5g/gCre. We also found by propensity-matched analyses that the number of steroid pulse in TSP was associated with renal outcome. In addition, remission of urinary protein at 1 year may predict renal outcome. All these findings may serve further studies for treatments of IgAN.
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