Mendelian Randomization Analysis of Pre-diagnostic Plasma Adipokine Levels and Colorectal Cancer Risk
| Project/Area Number |
15K08722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Yamaji Taiki 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 室長 (10466203)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 大腸がん / アディポカイン / メンデルの無作為化法 / コホート研究 / レプチン / アディポネクチン / Mendelian Randomization / FTO遺伝子 / 遺伝子多型解析 |
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| Outline of Final Research Achievements |
Supported by Grant-in-Aid for Scientific Research C, this researcher conducted a Mendelian randomization analysis for the association of pre-diagnostic plasma adipokine levels with colorectal cancer risk. This researcher observed a positive association between plasma leptin levels and colorectal cancer risk after controlling for known confounding factors. Of interest, the Mendelian randomization analysis revealed that an observed association was not fully explained by unknown confounding factors. These results should be interpreted in light of several limitations of the Mendelian randomization analysis, and further studies are needed to confirm the findings of this study.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study2016
Author(s)
Svensson T, Yamaji T, Budhathoki S, Hidaka A, Iwasaki M, Sawada N, Inoue M, Sasazuki S, Shimazu T, Tsugane S
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 36607-36607
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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