On Intra-Individual Variations in Hair Minerals Measured by PIXE in relation to Epidemiological Risk Assessment of Atopic Dermatitis
| Project/Area Number |
15K08733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Osaka University |
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Principal Investigator |
YAMADA TOMOMI 大阪大学, 医学部附属病院, 特任教授 (60363371)
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| Co-Investigator(Kenkyū-buntansha) |
中村 剛 中央大学, 理工学部, その他 (80039586)
世良 耕一郎 岩手医科大学, 医学部, 教授 (00230855)
森 弘行 長崎女子短期大学, その他部局等, 教授(移行) (30128227)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 測定誤差 / 毛髪PIXE / アトピー性皮膚炎 / PIXE / PIXE分析 |
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| Outline of Final Research Achievements |
In 2005, we conducted a cohort study of 834-mother-infant pairs to determine the relationship between hair minerals of mother and infant at one-month after birth and the onset of atopic dermatitis (AD) of infant at ten-months after birth. Six years after the initial research, we have sampled 209 six year-old children from the original cohort and noticed there were large variations in measurements of hair minerals measured by the particle induced X-ray emission method.
Investigating the statistical nature of the variations, we found that the most intra-individual variations in hair mineral measurements were normal random errors. Furthermore, inter-individual variations are approximated by ordinary parametric distributions. In other words, those variations are statistically tractable, or controllable. In conclusion, we have developed a method for the prediction of AD at 10 month after birth using two specimens of hair from each subject which outperforms the results of initial research.
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Report
(4 results)
Research Products
(26 results)
