Longitudinal study of cerebral atrophy, cognitive function for prevention of dementia

• Project/Area Number: 15K08736
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Ehime University
• Principal Investigator: IGASE MICHIYA 愛媛大学, 医学部附属病院, 准教授 (90314955)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脳萎縮 / 認知機能 / 軽度認知障害 / 脳MRI / 脈波伝搬速度 / 抗加齢ドック / 微小脳出血 / 無症候性ラクナ / 頚動脈エコー検査

Outline of Final Research Achievements

Seventy-eight subjects over the age of 40 (average age 66.1 ± 8.5 years old) who had no history of cerebral diseases such as cerebral infarction and were able to follow up with MRI over 1 year of MRI examination and cognitive function test results were analyzed. Regarding the degree of cerebral atrophy, the temporal horn area (THA) was examined by brain MRI. As a cognitive function test, a simple dementia screening test was used. There was a significant correlation between the THA and age, and also there was a significant gender differences. However, no significant correlation with the rate of change in THA and the rate of change in cognitive function. Because the subjects of this study were not included obvious dementia patients, it seems necessary to examine the relationship with mild cognitive impairment in the future study.

Research Products

• [Int'l Joint Research] University Medical Center Utrecht(オランダ)
• [Journal Article] Cross-sectional study of equol producer status and cognitive impairment in older adults. (2017)
  • Author(s): Igase M, Igase K, Tabara Y, Ohyagi Y, Kohara K
  • Journal Title: Geriatr Gerontol Int. Volume: - Issue: 11 Pages: 2103-2108
  • DOI: 10.1111/ggi.13029
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Skin Autofluorescence Examination as a Diagnostic Tool for Mild Cognitive Impairment in Healthy People. (2017)
  • Author(s): Igase M, Ohara M, Igase K, Kato T, Okada Y, Ochi M, Tabara Y, Kohara K, Ohyagi Y.
  • Journal Title: J Alzheimers Dis. Volume: 55 Issue: 4 Pages: 1481-1487
  • DOI: 10.3233/jad-160917
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Facial pigmentation as a biomarker of carotid atherosclerosis in middle-aged to elderly healthy Japanese subjects. (2015)
  • Author(s): Miyawaki S, Kohara K, Kido T, Tabara Y, Igase M, Miki T, Sayama K.
  • Journal Title: Skin Res Technol. Volume: in press Issue: 1 Pages: 20-24
  • DOI: 10.1111/srt.12223
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association of postural instability with asymptomatic cerebrovascular damage and cognitive decline: the Japan Shimanami Health Promoting Program study. (2015)
  • Author(s): Tabara Y, Okada Y, Ohara M, Uetani E, Kido T, Ochi N, Nagai T, Igase M, Miki T, Matsuda F, Kohara K.
  • Journal Title: Stroke. Volume: 46 Issue: 1 Pages: 16-22
  • DOI: 10.1161/strokeaha.114.006704
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Portable indices for sarcopenia are associated with pressure wave reflection and central pulse pressure: the J-SHIPP study. (2015)
  • Author(s): Ohara M, Kohara K, Tabara Y, Igase M, Miki T.
  • Journal Title: J Hypertens. Volume: 33 Issue: 2 Pages: 314-322
  • DOI: 10.1097/hjh.0000000000000394
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 高齢者のMCI診断におけるSAFの有用性 (2016)
  • Author(s): 伊賀瀬道也 他
  • Organizer: 日本老年医学会学術集会
  • Place of Presentation: 金澤
  • Year and Date: 2016-06-08
• [Presentation] Skin autofluorescence examination as a diagnostic tool for mild cognitive impairment in prehypertensives. (2016)
  • Author(s): Igase M et al.
  • Organizer: The American Society of Hypertension (ASH2016)
  • Place of Presentation: NY, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Usefullness of 3D Fast Spin-Echo Protcol for Vessel Wall Imaging in Cerebral Main Artery Stenosis. (2015)
  • Author(s): Igase M, Igase K, Sadamoto K and Kohara K.
  • Organizer: 7th WMIC meeting
  • Place of Presentation: ホノルル（USA）
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] 抗加齢ドックの検査結果から見えるもの ～フレイルの早期発見と寝たきり予防～ (2015)
  • Author(s): 伊賀瀬道也
  • Organizer: 第56回人間ドック学会学術大会
  • Place of Presentation: 横浜（神奈川）
  • Year and Date: 2015-07-31
  • Invited
• [Presentation] Effect of botulinum toxin therapy on blood pressure in patients with post-stroke upper limb spasticity. (2015)
  • Author(s): Igase M, Yamashita S, Fujisawa M and Kohara K.
  • Organizer: 24th European Stroke Conference
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2015-05-13
  • Int'l Joint Research