| Project/Area Number |
15K08738
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
Mukai Naoko 九州大学, 医学研究院, 講師 (90596826)
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| Co-Investigator(Kenkyū-buntansha) |
清原 裕 九州大学, 医学研究院, 教授 (80161602)
二宮 利治 九州大学, 医学研究院, 教授 (30571765)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | HbA1c / グリコアルブミン / GA/HbA1c比 / 1,5-アンヒドログルシトール / アルツハイマー病 / 1,5－アンヒドログルシトール / GA/ＨｂＡ1c比 / 心血管病 / 悪性腫瘍 / １，５－アンヒドログルシトール / 認知症 |
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| Outline of Final Research Achievements |
We examined the association of glycemic biomarkers with the development of Alzheimer’s disease (AD) in an average 4.8-year follow-up study of 1,187 community-dwelling Japanese subjects aged ≧65 years. The age- and sex-adjusted incidence of AD increased significantly with higher the glycated albumin (GA)/HbA1c ratio, and a similar tendency was seen for GA, while no such association was observed for HbA1c and 1,5-AG. After adjusting for potential confounding factors, positive association of the GA/HbA1c ratio with the risk of AD remained significant. Among subjects with normal glucose tolerance, those with high GA/HbA1c ratio had a higher risk of AD than those with low GA/HbA1c ratio, and a similar tendency was found in those with glucose intolerance. Our findings suggest that the GA/HbA1c ratio may be a useful biomarker for predicting incident AD.
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