Longitudinal association of glycemic biomarkers with diabetic complications in the community

• Project/Area Number: 15K08738
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyushu University
• Principal Investigator: Mukai Naoko 九州大学, 医学研究院, 講師 (90596826)
• Co-Investigator(Kenkyū-buntansha): 清原 裕 九州大学, 医学研究院, 教授 (80161602) ; 二宮 利治 九州大学, 医学研究院, 教授 (30571765)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: HbA1c / グリコアルブミン / GA/HbA1c比 / 1,5-アンヒドログルシトール / アルツハイマー病 / 1,5－アンヒドログルシトール / GA/ＨｂＡ1c比 / 心血管病 / 悪性腫瘍 / １，５－アンヒドログルシトール / 認知症

Outline of Final Research Achievements

We examined the association of glycemic biomarkers with the development of Alzheimer’s disease (AD) in an average 4.8-year follow-up study of 1,187 community-dwelling Japanese subjects aged ≧65 years. The age- and sex-adjusted incidence of AD increased significantly with higher the glycated albumin (GA)/HbA1c ratio, and a similar tendency was seen for GA, while no such association was observed for HbA1c and 1,5-AG. After adjusting for potential confounding factors, positive association of the GA/HbA1c ratio with the risk of AD remained significant. Among subjects with normal glucose tolerance, those with high GA/HbA1c ratio had a higher risk of AD than those with low GA/HbA1c ratio, and a similar tendency was found in those with glucose intolerance. Our findings suggest that the GA/HbA1c ratio may be a useful biomarker for predicting incident AD.

Research Products

• [Journal Article] Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study. (2018)
  • Author(s): Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: J Am Heart Assoc Volume: 7
  • DOI: 10.1161/jaha.117.006693
  • Peer Reviewed / Open Access
• [Journal Article] Alternative measures of hyperglycemia and risk of alzheimer's disease in the community: the Hisayama Study. (2017)
  • Author(s): Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 102 Pages: 3002-3010
  • DOI: 10.1210/jc.2017-00439
  • Peer Reviewed
• [Journal Article] Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. (2017)
  • Author(s): Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: Circulation Volume: 136 Pages: 516-525
  • DOI: 10.1161/circulationaha.116.025667
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population ― The Hisayama Study ― (2017)
  • Author(s): Umehara K, Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Kishimoto H, Kitazono T, Hoka S, Kiyohara Y, Ninomiya T
  • Journal Title: Circ J Volume: 81 Issue: 9 Pages: 1315-1321
  • DOI: 10.1253/circj.cj-16-0954 10.1253/circj.CJ-16-0954
  • NAID: 130006003854
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] White-coat and masked hypertension are associated with albuminuria in a general population: the Hisayama Study. (2017)
  • Author(s): Hata J, Fukuhara M, Sakata S, Arima H, Hirakawa Y, Yonemoto K, Mukai N, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Hypertens Res Volume: 40 Pages: 937-943
  • DOI: 10.1038/hr.2017.74
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study (2017)
  • Author(s): Usui T, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: J Atheroscler Thromb Volume: 24 Issue: 7 Pages: 706-715
  • DOI: 10.5551/jat.37044
  • NAID: 130006827175
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Dietary protein intake and stroke risk in a general Japanese population: the Hisayama Study (2017)
  • Author(s): Ozawa M, Yoshida D, Hata J, Ohara T, Mukai N, Shibata M, Uchida K, Nagata M, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Stroke Volume: 48 Pages: 1478-1486
  • DOI: 10.1161/strokeaha.116.016059
  • Peer Reviewed
• [Journal Article] Morning and Evening Blood Pressures Are Associated With Intima-Media Thickness in a General Population ― The Hisayama Study ― (2017)
  • Author(s): Sakata S, Hata J, Fukuhara, M, Yonemoto, K, Mukai N, Yoshida D, Kishimoto H, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Circ J Volume: 81 Issue: 11 Pages: 1647-1653
  • DOI: 10.1253/circj.cj-16-1306 10.1253/circj.CJ-16-1306
  • NAID: 130006179861
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cancer death in a Japanese community: The Hisayama Study (2017)
  • Author(s): Nagata M, Hata J, Hirakawa Y, Mukai N, Yoshida D, Ohara T, Kishimoto H, Kawano H, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Journal of Epidemiology Volume: 27 Issue: 12 Pages: 578-583
  • DOI: 10.1016/j.je.2017.01.004
  • NAID: 130006832552
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Trends in dementia prevalence, incidence, and survival rate in a Japanese community (2017)
  • Author(s): Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y.
  • Journal Title: Neurology Volume: 印刷中 Pages: 1925-1932
  • DOI: 10.1212/wnl.0000000000003932
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association of Airflow Limitation With Carotid Atherosclerosis in a Japanese Community ― The Hisayama Study ― (2017)
  • Author(s): Kudo K, Hata J, Matsumoto K, Shundo Y, Fukuyama S, Inoue H, Kitazono T, Kiyohara Y, Ninomiya T, Nakanishi Y
  • Journal Title: Circ J Volume: 81 Issue: 12 Pages: 1846-1853
  • DOI: 10.1253/circj.cj-16-1305 10.1253/circj.CJ-16-1305
  • NAID: 130006219104
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Serum Uric Acid as a Risk Factor for Chronic Kidney Disease in a Japanese Community – The Hisayama Study – (2016)
  • Author(s): 1.Takae K, Nagata M, Hata J, Mukai N, Hirakawa Y, Yoshida D, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T.
  • Journal Title: Circ J Volume: 80 Issue: 8 Pages: 1857-1862
  • DOI: 10.1253/circj.cj-16-0030 10.1253/circj.CJ-16-0030
  • NAID: 130005166109
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum angiopoietin-like protein 2 (ANGPTL2) is a novel risk factor for cardiovascular disease in the community: the Hisayama Study. (2016)
  • Author(s): Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y & Ninomiya T.
  • Journal Title: Aterioscler Thromb Vasc Biol Volume: 36 Pages: 1686-1691
  • DOI: 10.1161/atvbaha.116.307291
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study. (2016)
  • Author(s): 4.Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
  • Journal Title: Diabetes Care Volume: 39 Pages: 1543-1549
  • DOI: 10.2337/dc15-2800
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The long-term association between physical activity and risk of dementia in the community: the Hisayama Study. (2016)
  • Author(s): Hiro Kishimoto, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Fumie Ikeda, Masayo Fukuhara, Shuzo Kumagai, Shigenobu Kanba, Takanari Kitazono, Yutaka Kiyohara.
  • Journal Title: Eur. J. Epidemiol. Volume: 31 Pages: 267-274
  • DOI: 10.1007/s10654-016-0125-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Combination of <i>Helicobacter pylori</i> Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study (2016)
  • Author(s): 5.Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T
  • Journal Title: Journal of Epidemiology Volume: 26 Issue: 12 Pages: 629-636
  • DOI: 10.2188/jea.je20150258 10.2188/jea.JE20150258
  • NAID: 130005179539
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study (2015)
  • Author(s): Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y
  • Journal Title: Cardiovasc Diabetol Volume: 14 Pages: 84-84
  • DOI: 10.1186/s12933-015-0247-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hematocrit and the risk of cardiovascular disease in a Japanese community: the Hisayama Study (2015)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Ago T, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 242 Pages: 199-204
  • DOI: 10.1016/j.atherosclerosis.2015.07.014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study (2015)
  • Author(s): Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y
  • Journal Title: J Am Geriatr Soc Volume: 63 Pages: 2332-2339
  • DOI: 10.1111/jgs.13794
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Angiotensin I-Converting Enzyme Gene Polymorphism Enhances the Effect of Hypercholesterolemia on the Risk of Coronary Heart Disease in a General Japanese Population: The Hisayama Study (2015)
  • Author(s): Kondo H, Ninomiya T, Hata J, Hirakawa Y, Yonemoto K, Arima H, Nagata M, Tsuruya K, Kitazono T, Kiyohara Y
  • Journal Title: J Atheroscler Thromb Volume: 22 Issue: 4 Pages: 390-403
  • DOI: 10.5551/jat.24166
  • NAID: 130004700293
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Presentation] 糖尿病と認知症の関連 疫学的観点から：久山町研究 (2018)
  • Author(s): 向井直子、二宮利治
  • Organizer: 第52回糖尿病学の進歩
  • Invited
• [Presentation] 地域住民における血糖関連指標とアルツハイマー病発症との関連：久山町研究 (2017)
  • Author(s): 向井直子、小原知之、秦 淳、平川洋一郎、吉田大悟、岸本裕歩、古賀正史、中村宇大、北園孝成、清原 裕、二宮利治
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 地域住民における血清ビタミンD値が総死亡および死因別死亡に与える影響：久山町研究 (2016)
  • Author(s): 梅原 薫、向井直子、秦 淳、平川洋一郎、吉田大悟、岸本裕歩、清原 裕、二宮利治
  • Organizer: 第75回日本公衆衛生学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2016-10-26
• [Presentation] 一般住民における血清尿酸値と心血管病死亡との関連：久山町研究 (2016)
  • Author(s): 坂田智子、秦 淳、向井直子、吉田大悟、北園孝成、清原 裕、二宮利治
  • Organizer: 第52回日本循環器病予防学会学術集会
  • Place of Presentation: さいたま市
  • Year and Date: 2016-06-17
• [Presentation] 一般住民におけるアルブミン尿と認知症発症の関係：久山町研究 (2016)
  • Author(s): 髙江啓太、永田雅治、小原知之、秦 淳、鶴屋和彦、北園孝成、清原 裕、二宮利治
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-06-17
• [Presentation] Elevated 2-hour post-load glucose levels and longer duration of diabetes are risk factors for hippocampal atrophy in elderly Japanese: the Hisayama Study (2016)
  • Author(s): Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Goto S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
  • Organizer: the American Diabetes Association's 76th Scientific Sessions
  • Place of Presentation: New Orleans, Louisiana, U.S.
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] 地域高齢者における野菜・果実の摂取と認知機能の関係：久山町研究 (2016)
  • Author(s): 吉田大悟、津野崎希、小原知之、岸本裕歩、秦 淳、柴田舞欧、向井直子、北園孝成、清原 裕、二宮利治
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 金沢市
  • Year and Date: 2016-06-08
• [Presentation] 糖尿病合併症のバイオマーカーとしてのグリコアルブミンの臨床的意義 (2016)
  • Author(s): 向井直子
  • Organizer: 第23回日本未病システム学会学術総会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 地域高齢者における糖尿病と頭部MRI上の海馬萎縮との関係：久山町研究 (2015)
  • Author(s): 平林直樹, 秦 淳, 小原知之, 向井直子, 永田雅治, 柴田舞欧, 後藤聖司, 古田芳彦, 山下典生, 吉原一文, 北園孝成, 須藤信行, 清原 裕, 二宮利治
  • Organizer: 第22回日本未病システム学会学術総会
  • Place of Presentation: 札幌市
  • Year and Date: 2015-10-11
• [Presentation] 家庭血圧の日間変動と認知症発症との関連：久山町研究 (2015)
  • Author(s): 大石絵美, 小原知之, 福原正代, 坂田智子, 秦 淳, 大坪俊夫, 松村 潔, 北園孝成, 清原 裕, 二宮利治
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2015-10-09
• [Presentation] 地域高齢住民における認知症の疫学：久山町研究 (2015)
  • Author(s): 小原知之, 清原 裕, 二宮利治
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2015-10-09
  • Invited
• [Presentation] 動脈硬化性疾患の新しい危険因子：久山町研究から (2015)
  • Author(s): 秦 淳, 清原 裕
  • Organizer: 第47回日本動脈硬化学会総会
  • Place of Presentation: 仙台市
  • Year and Date: 2015-07-09
  • Invited
• [Presentation] 握力の経年変化が総死亡および死因別死亡に与える影響：久山町研究 (2015)
  • Author(s): 岸本裕歩, 秦 淳, 吉田大悟, 池田文恵, 向井直子, 永田雅治, 小原知之, 二宮利治, 北園孝成, 清原 裕
  • Organizer: 第51回日本循環器病予防学会学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2015-06-26
• [Book] 心房細動による脳卒中の疫学 (2015)
  • Author(s): 古田芳彦, 秦 淳, 清原 裕
  • Total Pages: 10
  • Publisher: メディカルレビュー社
• [Remarks] 九州大学大学院医学研究院 衛生・公衆衛生学分野
  • URL: http://www.eph.med.kyushu-u.ac.jp/
• [Remarks] 九州大学大学院医学研究院 環境医学分野
  • URL: http://www.envmed.med.kyushu-u.ac.jp/