Study of usefulness of behavior modification assessment for the preventive strategy of CKD

• Project/Area Number: 15K08742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Iwate Medical University (2018); Fukushima Medical University (2015-2017)
• Principal Investigator: Asahi Koichi 岩手医科大学, 医学部, 教授 (60274966)
• Co-Investigator(Kenkyū-buntansha): 木村 浩 福島県立医科大学, 医学部, 助教 (30595608)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 慢性腎臓病 / 生活習慣 / 保健指導 / 一次予防 / 重症化予防 / 生活習慣病 / ライフスタイル / 行動変容

Outline of Final Research Achievements

We intended to analyze the standard analysis files edited from nationwide health checkup survey database and to clarify the association between behavior modification stage and onset or progression of CKD in general population who participated in specific health checkup. As a result of analyses, we obtained several interesting findings about following themes. 1) The effect of smoking on the association of alcohol and CKD, 2) The association of overall lifestyle modification and incidence of proteinuria, 3) The association of hypertriglyceridemia with the incidence and progression of CKD and modification of the association by daily alcohol consumption, 4) The association of alcohol consumption and incidence of proteinuria, 5) The association of fast eating and new-onset of diabetes, 6) The association of walking speed and new-onset of diabetes. Further detailed investigation is necessary to clarify the relationships between behavior modification stage and onset or progression of CKD.

Academic Significance and Societal Importance of the Research Achievements

本研究で種々の生活習慣因子とCKD発症進展の関連やその関連性に対するその他の生活習慣の影響，生活習慣全般の改善へ向けた行動変容のCKD新規発症抑制の可能性などの新たな学術的成果が得られた．これらの成果はCKDや背景となる広汎な生活習慣関連疾患の発症進展予防のための具体的な保健指導法や療養指導法の開発や保健施策の立案に寄与することが期待される．

Research Products

• [Journal Article] Low fasting plasma glucose level as a predictor of new-onset diabetes mellitus on a large cohort from a Japanese general population. (2018)
  • Author(s): Ogata E, Asahi K, Yamaguchi S, Iseki K, Sato H, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Shibagaki Y, Kasahara M, Watanabe T, Shimabukuro M.
  • Journal Title: Sci Rep Volume: 8 Pages: 13927-13927
  • Peer Reviewed
• [Journal Article] Alcohol consumption and incidence of proteinuria: a retrospective cohort study (2018)
  • Author(s): Kimura Y. Yamamoto R, Isaka Y, Iseki K, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Moriyama T, Watanabe T.
  • Journal Title: Clin Exp Nephrol Volume: 22 Pages: 1133-1142
  • Peer Reviewed
• [Journal Article] Alcohol consumption and incidence of proteinuria: a retrospective cohort study. (2018)
  • Author(s): Kimura Y. Yamamoto R, Isaka Y, Iseki K, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Moriyama T, Watanabe T
  • Journal Title: Clin Exp Nephrol Volume: -
• [Journal Article] Association of hypertriglyceridemia with the incidence and progression of chronic kidney disease and modification of the association by daily alcohol consumption (2017)
  • Author(s): Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K, Iseki C, Fujimoto S, Konta T, Moriyama T, Yamagata K, Narita I, Kimura K, Kondo M, Asahi K, Watanabe T
  • Journal Title: J Ren Nutr Volume: 27 Pages: 381-394
  • Peer Reviewed
• [Journal Article] Associations between serum uric acid levels and the incidence of nonfatal stroke: a nationwide community-based cohort study (2017)
  • Author(s): Kamei K, Konta T, Hirayama A, Ichikawa K, Kubota I, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Shibagaki Y, Kasahara M, Asahi K, Watanabe T
  • Journal Title: Clin Exp Nephrol Volume: -
  • Peer Reviewed
• [Journal Article] Mortality risk among screened subjects of the specific health check and guidance program in Japan 2008-2012 (2017)
  • Author(s): Iseki K, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Konta T, Kasahara M, Shibagaki Y, Yoshida H, Moriyama T, Kondo M, Iseki C, Watanabe T
  • Journal Title: Clin Exp Nephrol Volume: -
  • Peer Reviewed
• [Journal Article] Association between overall lifestyle changes and incidence of proteinuria: a population-based, cohort study (2017)
  • Author(s): Wakasugi M, Kazama JJ, Narita I, Iseki K, Fujimoto S, Moriyama T, Yamagata K, Konta T, Tsuruya K, Asahi K, Kondo M, Kurahashi I, Ohashi Y, Kimura K, Watanabe T
  • Journal Title: Intern Med Volume: -
  • NAID: 130006856811
  • Peer Reviewed
• [Journal Article] Body mass index modifies an association between self-reported regular exercise and proteinuria (2016)
  • Author(s): Nagasawa Y, Yamamoto R, Shinzawa M, Hasuike Y, Kuragano T, Isaka Y, Nakanishi T, Iseki K, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Moriyama T, Watanabe T.
  • Journal Title: J Atheroscler Thromb Volume: 23 Pages: 402-412
  • Peer Reviewed
• [Journal Article] Control status of atherosclerotic cardiovascular risk factors among Japanese high-risk subjects:analyses of a Japanese health check database from 2008 to 2011 (2016)
  • Author(s): Hasegawa K, Tsukamoto K, Kunimi M, Asahi K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kimura K, Ohashi Y, Watanabe T
  • Journal Title: J Atheroscler Thromb Volume: 23 Pages: 991-1003
  • NAID: 130005254340
  • Peer Reviewed
• [Journal Article] Control status of atherosclerotic cardiovascular risk factors among Japanese high-risk suubjects: Analyses of a Japanese Health Check Database from 2008 through 2011 (2016)
  • Author(s): Hasegawa K, Tsukamoto K, Kunimi M, Asahi K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kimura K, Kurahashi I, Ohashi Y, Watanabe T
  • Journal Title: J Atheroscler Thromb Volume: *
  • Peer Reviewed
• [Presentation] Recent prevalence and characteristic of CKD including diabetic kidney disease among participants of nationwide health check program in Japan (2018)
  • Author(s): Asahi K, Nagai K, Tsunoda R, Tsuruya K, Iseki K, Yamagata K.
  • Organizer: Kidney Week 2018
  • Int'l Joint Research
• [Presentation] 慢性腎臓病の有無による朝食を抜く食習慣と死亡の関係 (2018)
  • Author(s): 古澤彩美, 村澤昌, 内田大介, 木戸亮, 河原崎宏雄, 渡辺毅, 井関邦俊, 守山敏樹, 山縣邦弘, 鶴屋和彦, 今田恒夫, 成田一衛, 近藤正英, 笠原正登, 旭浩一, 柴垣有吾
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] 慢性腎臓病の有無による歩行速度と死亡の関係 (2018)
  • Author(s): 村澤昌, 古澤彩美, 内田大介, 木戸亮, 河原崎宏雄, 渡辺毅, 井関邦敏, 守山敏樹, 山縣邦弘, 鶴屋和彦, 藤元昭一, 今川恒夫, 成田一衛, 近藤正英, 笠原正登, 旭浩一, 柴垣有吾
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] CKD患者における飲酒量と腎機能予後 後向きコホート研究 (2018)
  • Author(s): 木村良紀, 山本陵平, 猪阪善隆, 井関邦敏, 山縣邦弘, 鶴屋和彦, 吉田英昭, 藤元昭一, 旭浩一, 守山敏樹, 渡辺毅
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] 運動要因および食行動要因と糖尿病新規発症の関連 65才未満群および65才以上群での検討 (2017)
  • Author(s): 岩崎麻里子, 旭 浩一, 島袋充生ほか
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] 食行動要因の糖尿病新規発症におよぼす影響 特定健診受診者における解析 (2017)
  • Author(s): 工藤明宏, 旭 浩一, 島袋充生ほか
  • Organizer: 第60回日本糖尿病学会年次学術集会
• [Presentation] The effect of high alcohol consumption on incidence of proteinuria was different by gender: a retrospective cohort study (2017)
  • Author(s): Kimura Y, Asahi K. et al.
  • Organizer: Kidney Week 2017 (Annual Meeting of American Society of Nephrology)
• [Presentation] 特定健診から見えるCKDのリスク (2016)
  • Author(s): 旭浩一
  • Organizer: 第18回国際腎と栄養代謝学会(第１回世界腎と栄養週間）
  • Place of Presentation: 沖縄県宜野湾市
  • Int'l Joint Research
• [Presentation] Expected risk of death by CKD stage using stochastic linkage between death certificates and the specific health check programme cohort in Japan (2016)
  • Author(s): Kondo M, Yamamura M, Iseki C, IsekiK, Asahi K, Yamagata K, Fujimoto S, Tsuruya K, Moriyama T, Narita I, Konta T, Shibagaki Y, Kasahara M, Watanabe T
  • Organizer: 53rd ERA-EDTA Congress
  • Place of Presentation: Vienna
  • Int'l Joint Research
• [Presentation] Regional differences in chronic kidney disease prevalence and incident dialysis in Japan: a Japanese nationwide health check study (2016)
  • Author(s): Yasuda Y, Kamiya M, Nakatochi M, Nakai S, Shibata K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Watanabe T, Maruyama S
  • Organizer: 53rd ERA-EDTA Congress
  • Place of Presentation: Vienna
  • Int'l Joint Research
• [Presentation] The association between serum uric acid and incidence of non-fatal stroke in the CKD population (2016)
  • Author(s): Kamei K, Araumi A, Watanabe S, Sato H, Ichikawa K, Konta K, IsekiK, Yamagata K, Fujimoto S, Tsuruya K, Narita I, Moriyama T, Shibagaki Y, Asahi K, Kondo M, Kasahara M, Watanabe T
  • Organizer: 53rd ERA-EDTA Congress
  • Place of Presentation: Vienna
  • Int'l Joint Research
• [Presentation] 慢性腎臓疾患(CKD)有病者数の地域差は透析導入患者数に関連する (2016)
  • Author(s): 安田宜成，神谷真由美，中杤昌弘，井関邦敏，守山敏樹，山縣邦弘，鶴屋和彦，吉田英昭，藤元昭一，旭浩一，渡辺毅，中井滋，丸山彰一
  • Organizer: 第61回日本透析医学会学術集会・総会
  • Place of Presentation: 大阪
• [Presentation] 特定健康診査による個人リスク評価に基づく、保健指導と連結した効果的なCKD地域医療連携システムの制度設計 (2016)
  • Author(s): 旭浩一，渡辺毅
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Lowering diastolic blood pressure was associated with higher incidence of chronic kidney disease in general population only in those using antihypertensive medication (2016)
  • Author(s): Uchida D, Kido R, Kawarazaki H, Murasawa M, Fujimoto S, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Konta T, Narita I, Kondo M, Kasahara M, Asahi K, Watanabe T, Shibagaki Y
  • Organizer: Kidney Week 2016
  • Place of Presentation: Chicago
  • Int'l Joint Research
• [Presentation] International variations in the frequency of the types of patient-physician contact for CKD patients: early findings from CKDopps (2016)
  • Author(s): Speyer E, Stengel B, Asahi K, Bieber B, Lopes AA, Pisoni RL, Sukul N, Tentori F
  • Organizer: Kidney Week 2016
  • Place of Presentation: Chicago
  • Int'l Joint Research
• [Presentation] Transient dipstick-proteinuria could be a risk of cardio-vascular diseases (2015)
  • Author(s): Nagai K, Yamagata K, Asahi K et al.
  • Organizer: Kidney Week 2015
  • Place of Presentation: San Diego
  • Year and Date: 2015-11-05
  • Int'l Joint Research