The synergistic effect of heavy metal exposure and periodontal disease on preterm birth and/or low birth weight
Project/Area Number |
15K08747
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Jichi Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
香山 不二雄 自治医科大学, 医学部, 客員教授 (50177614)
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Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Takahiko 旭川医科大学, 医学部, 教授 (90200998)
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Research Collaborator |
MIZUNO Atsuko 自治医科大学, 医学部 (30364532)
OHTSU Mayumi 自治医科大学, 医学部 (00644238)
KOBAYASHI Yayoi 国立研究開発法人国立環境研究所, 研究員 (00391102)
TAKAGI Mai 国立研究開発法人国立環境研究所, 研究員 (40615978)
FATMI Zafar Aga Khan University
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 重金属 / 歯周病 / 早産 / 低体重児出産 |
Outline of Final Research Achievements |
We estimated the synergistic effect of heavy metal exposure and periodontal disease on preterm birth and/or low birth weight in Japan and Pakistan. Low birth weight was significantly increased by the combination of heavy metal exposure and periodontal disease, it displayed the synergistic effect of negative in pregnancy. Major important sources of exposure to heavy metals in Pakistan were lead in food and house dust, and arsenic in drinking water.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] External lead contamination of women's nails by surma in Pakistan: Is the biomarker reliable?2016
Author(s)
Ikegami, A. Takagi, M. Fatmi, Z. Kobayashi, Y. Ohtsu, M. Cui, X. Mise, N. Mizuno, A. Sahito, A. Khoso, A. Kayama, F.
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Journal Title
Environmental Pollution
Volume: 218巻
Pages: 723-727
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan.2016
Author(s)
Kayama F, Fatmi Z, Ikegami A, Mizuno A, Ohtsu M, Mise N, Cui X, Ogawa M, Sakamoto T, Nakagi Y, Yoshida T, Sahito A, Naeem S, Ghias K, Zuberi H, Tariq K, Kobayashi Y, Nohara K.
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Journal Title
Rev. Environ. Health.
Volume: 31(1)
Issue: 1
Pages: 33-35
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] External Lead Contamination of Women's Nails by Surma in Pakistan: Is the Biomarker Reliable?2016
Author(s)
Akihiko Ikegami, Mai Takagi, Zafar Fatmi, Yayoi Kobayashi, Mayumi Ohtsu, Xiaoyi Cui, Nathan Mise, Atsuko Mizuno, Ambreen Sahito, Aneeta Khoso, Fujio Kayama
Organizer
5th Conference on Prenatal Programming and Toxicity
Place of Presentation
Kitakyushu International Conference Center (Kitakyushu, Fukuoka, Japan)
Year and Date
2016-11-13
Related Report
Int'l Joint Research
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[Presentation] Lead and arsenic exposures assessment among pregnant mother and infants in Pakistan and Japan2016
Author(s)
Fujio Kayama, Zafar Fatmi, Ambreen Sahito, Akihiko Ikegami, Atsuko Mizuno, Mayumi Ohtsu, Nathan Mise, Xiaoyi Cui, Masanori Ogawa, Takako Sakamoto, Yoshiko Nakagi, Takahiko Yoshida, Mai Takagi, Yayoi Kobayashi, Keiko Nohara
Organizer
5th Conference on Prenatal Programming and Toxicity
Place of Presentation
Kitakyushu International Conference Center (Kitakyushu, Fukuoka, Japan)
Year and Date
2016-11-13
Related Report
Int'l Joint Research
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[Presentation] The developmental effects by children’s dietary intake of lead and arsenic in Japan and Pakistan -PbAs study-2016
Author(s)
Mayumi Ohtsu, Yoshihiko Nakagi, Xiaoyi Cui, Nathan Mise, Akihiko Ikegami, Atsuko Mizuno, Yayoi Kobayashi, Fatami Zafer, Takahiko Yoshida, Fujio Kayama
Organizer
48th Asia-Pacific Academic Consortium for Public Health Conference
Place of Presentation
Teikyo University (Itabashi, Tokyo, Japan)
Year and Date
2016-09-16
Related Report
Int'l Joint Research
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[Presentation] Lead and arsenic from food and Health Effects among Vulnerable Populations in Pakistan and Japan2016
Author(s)
Fujio Kayama, Zafar Fatmi, Ambreen Sahito, Akihiko Ikegami, Atsuko Mizuno, Mayumi Ohtsu, Nathern Mise, Xiaoyi Cui, Masanori Ogawa, Takako Sakamoto, Yoshiko
Organizer
Conference of International Society for Environmental Epidemiology and Internationa Society of Exposure Science - Asia Chapter 2016
Place of Presentation
Conference Hall, Hokkaido University (Sapporo, Hokkaido, Japan)
Year and Date
2016-06-26
Related Report
Int'l Joint Research
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