Worksite-based epidemiological study for examining utility of serum polyunsaturated fatty acid levels for predicting new-onset metabolic syndrome in workingmen.

• Project/Area Number: 15K08752
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Nippon Medical School
• Principal Investigator: Otsuka Toshiaki 日本医科大学, 医学部, 准教授 (80339374)
• Co-Investigator(Kenkyū-buntansha): 川田 智之 日本医科大学, 大学院医学研究科, 大学院教授 (00224791) ; 小谷 英太郎 日本医科大学, 医学部, 講師 (10287708)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: メタボリック症候群 / 多価不飽和脂肪酸 / 疫学研究 / コホート研究 / メタボリックシンドローム / 不飽和脂肪酸 / 中年男性 / 予防医学 / 危険因子

Outline of Final Research Achievements

Metabolic syndrome (MetS) is well known to be a major risk factor for cardiovascular disease, not only in Western countries but also in Japan. It is therefore important to prevent new-onset MetS to further support health promotion for Japanese people. We conducted worksite-based epidemiological study to examine whether serum ω-3 polyunsaturated fatty acid levels were predictive of new-onset MetS in Japanese workingmen. However, any polyunsaturated fatty acid levels measured in this study (eicosapentaenoic acid, docosahexaenoic acid, and eicosapentaenoic acid/arachidonic acid ratio) did not show significant predictive values for new-onset MetS in this study population. Further studies are needed to elucidate the longitudinal association between ω-3 polyunsaturated fatty acid levels and the risk of new-onset MetS.

Research Products

• [Remarks] 日本医科大学 衛生学公衆衛生学
  • URL: http://www2.nms.ac.jp/nms/dhph/