A cohort study of maternal urinary biomarkers during pregnancy in relation to changes in blood pressure and their children's food preference
| Project/Area Number |
15K08755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
磯 博康 大阪大学, 医学系研究科, 教授 (50223053)
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| Co-Investigator(Renkei-kenkyūsha) |
UMESAWA Mitsumasa 独協医科大学, 大学院医学系研究科, 准教授 (00567498)
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| Research Collaborator |
KIMURA Takashi 大阪大学, 大学院医学系研究科, 特任助教
TANIGAWA Kanami 大阪大学, 大学院医学系研究科, 大学院生
AOCHI Yuri 大阪大学, 大学院医学系研究科, 大学院生
CUI Meishan 大阪大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 妊婦 / 子ども / 血圧 / 食嗜好 / 尿中バイオマーカー / 小児 |
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| Outline of Final Research Achievements |
As for spot urine in the 1st trimester, Mg/Cre and UN/Cre were inversely associated with blood pressure (BP) levels during pregnancy and one month after childbirth, and Ca/Cre was inversely associated with BP levels one month after childbirth. Na/K was positively associated with BP levels during pregnancy and one month after childbirth.
As for spot urine in the 2nd-to-3rd trimester, Mg/Cre was inversely associated with BP levels during pregnancy and one month after childbirth. Ca/Cre was positively associated with systolic BP (SBP) levels in the 2nd and 3rd trimesters. Na/K was positively associated with SBP levels in the 3rd trimester. UN/Cre was inversely associated with BP levels in the 3rd trimester and one month after childbirth.
For taste preference in 4.5-year children, maternal Na/K in the 1st trimester was inversely associated with sweet food preference, while Na/Cre in the 2nd-to-3rd trimester was positively associated with salty food preference.
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Report
(4 results)
Research Products
(1 results)
