Investigation of Varicella zoster Virus Specific Immune Response for Prevention of Shingles in people with Diabetes.

• Project/Area Number: 15K08759
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: The Tazuke Kofukai
• Principal Investigator: HATA Atsuko 公益財団法人田附興風会, 医学研究所 第4研究部, 研究主幹 (70321685)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 水痘帯状疱疹ワクチン / 糖尿病 / 細胞性免疫 / 液性免疫 / IFN-γ アッセイ / 同時接種 / 23価肺炎球菌ワクチン / 帯状疱疹 / 水痘ワクチン / 二重盲検比較試験 / 高齢者 / 二重盲検プラセボ対照ランダム化比較試験 / IFNγアッセイ / 水痘帯状疱疹ウイルス

Outline of Final Research Achievements

Cell-mediated immunity against live varicella-zoster vaccine with 23 valent pneumococcal polysaccharide vaccine simultaneously for people with diabetes aged 50 years or over resulted in a low response assessed by varicella-zoster virus (VZV) antigen skin test. We changed the method and found that VZV-specific cell-mediated immunity after varicella-zoster vaccination in healthy adults can be evaluated by whole blood IFN-γ assay by VZV antigen stimulation. A randomized double blind placebo-controlled trial with varicella-zoster vaccine and placebo in people with diabetes over the age of 50 years was conducted. VZV specific cell-mediated immunity was assessed by this whole blood IFN-γ assay and humoral immunity and safety to the varicella-zoster vaccine were also evaluated. 85 people were registered by June 2018, the final blood sampling one year after the last vaccination is scheduled to be completed in July 2018.

Research Products

• [Journal Article] Herpes zoster meningitis in immunocompetent children: Two case reports and a literature review. (2017)
  • Author(s): Itoh N, Motokura K, Kumakura A, Hata D, Hata A.
  • Journal Title: Pediatr Int. Volume: 59 Issue: 10 Pages: 1116-1118
  • DOI: 10.1111/ped.13362
  • Peer Reviewed
• [Journal Article] Efficacy and safety of live varicella zoster vaccine in diabetes: a randomized, double-blind, placebo-controlled trial (2016)
  • Author(s): Hata A, Inoue F, Hamamoto Y, Yamasaki M, Fujikawa J, Kawahara H, Kawasaki Y, Honjo S, Koshiyama H, Moriishi E, Mori Y, Ohkubo T.
  • Journal Title: Diabet Med. Volume: 33 Issue: 8 Pages: 1094
  • DOI: 10.1111/dme.13038
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Vaccine-strain herpes zoster found in the trigeminal nerve area in a healthy child: A case report. (2016)
  • Author(s): Iwasaki S, Motokura K, Honda Y, Mikami M, Hata D, Hata A.
  • Journal Title: J Clin Virol. Volume: 85 Pages: 44-47
  • DOI: 10.1016/j.jcv.2016.10.022
  • Peer Reviewed
• [Presentation] 帯状疱疹と水痘ワクチン (2018)
  • Author(s): 羽田敦子
  • Organizer: 第15回北大阪感染症研究会
  • Invited
• [Presentation] Humoral immunity to varicella zoster virus 7 years after varicella vaccination (2017)
  • Author(s): Atsuko Hata、 Kentaro Kato, Ryoko Akashi-Ueda, Kenji Nakagawa, Junya Abe, Sumie Yamashita, Akira Kumakura, Yui Itou, Toshihiko Nanbara, Takakazu Yoshioka, Hiroshi Mizumoto, Mitsutaka Shiota, Ken Watanabe, Daisuke Hata.
  • Organizer: 35th annual meeting of the ESPID. Madrid, Spain 23-27 May 2017
  • Int'l Joint Research
• [Presentation] 健常成人における水痘帯状疱疹ワクチンの細胞性免疫能増強 (2017)
  • Author(s): 羽田敦子、辻本考、加藤瑞樹、丸毛聡、上田覚、四茂野恵奈、菊池航紀、藤本卓司、秦大資、奥野壽臣
  • Organizer: 第91回日本感染症学会総会・学術講演会
• [Presentation] 予防接種に関しての最新のトピックス (2017)
  • Author(s): 羽田敦子
  • Organizer: 東淀川区病診連携会講演会
  • Invited
• [Presentation] 健常成人における水痘帯状疱疹ワクチンの細胞性免疫能評価 (2016)
  • Author(s): 〇羽田敦子，榊原敦子，奥野壽臣
  • Organizer: 第20回日本ワクチン学会学術集会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 2016-10-22
• [Presentation] 高齢糖尿病患者における水痘帯状疱疹ワクチンランダム化二重盲検試験後の同時接種23価肺炎球菌多糖体ワクチン免疫応答解析 (2016)
  • Author(s): ○羽田敦子，石岡大成，大石和徳
  • Organizer: 第90回日本感染症学会総会・学術講演会
  • Place of Presentation: 仙台市、仙台国際センター
  • Year and Date: 2016-04-16