Assessment of HDL levels and Risk of a First Myocardial Infarction Among Bangladeshi population: A comparison with the data of Japanese population

• Project/Area Number: 15K08760
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: Okazaki Osamu 国立研究開発法人国立国際医療研究センター, その他部局等, 第3循環器内科医長 (30203970)
• Co-Investigator(Kenkyū-buntansha): Jesmin Subrina 筑波大学, 体育系, 研究員 (60374261)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 予防医学 / 心筋梗塞 / 日本 / バングラデシュ / HDL

Outline of Final Research Achievements

We analyzed the ACS (acute coronary syndrome) patients of 738 conducted in Bangladesh and their age and sex adjusted control subjects. Overall low HDL prevalence was found in about 52% of these ACS patients (male 44.7% vs. female 74.3%). The prevalence of low HDL in ACS patients did not differ in rural and urban Bangladesh. Prevalence of low HDL among STEMI (Total-51.0%, Male-46.9%, Female-72.6%); among non-STEMI (Total-48.8%, Male-39.4%, Female-87.5%); among unstable angina (Total-52.0%, M-40.9%, F-72.9%) of sub groups of ACS patients. From these data, it is obviously clear that low HDL prevalence is highly dominated in female ACS patients in Bangladesh. Mean level of cardiac troponin in low HDL ACS patient vs. normal HDL ACS subject was 26.6 ng/ml vs. 14.7 ng/ml (p=0.001). The ACS patients who had previous history of angina the prevalence of low HDL was 39.02%, in contrast ACS patients having previous history of myocardial infarction was 25%

Research Products

• [Int'l Joint Research] HDRCRP/ボグラ医科大学/Shuvo Diagnostic Center(バングラデシュ)
• [Int'l Joint Research] HDRCRP/ボグラ医科大学/Shuvo Diagnostic Center Dhunat(バングラデシュ)
• [Int'l Joint Research] HDRCRP/Bogla Medical college/Dhaka Medical college(Bangladesh)
• [Journal Article] Prevalence of metabolic syndrome components among early age onset acute in coronary syndrome patients in Bangladesh (2016)
  • Author(s): Abdullah Al Mamun, Subrina Jesmin, Md. Arifur Rahman, AKM Ahsan Habib, Md. Majdul Islam, Nobutake Shimojo, Sayeeda Nusrat Sultana, Farzana Sohael, Osamu Okazaki, Masao Moroi, Satoru Kawano
  • Journal Title: Endocrine Practice Volume: Supplementary issue Pages: 121-121
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] (National burden on non-communicable disease risk factors in Bangladesh (2016)
  • Author(s): Abdullah Al Mamun, Subrina Jesmin, Md. Arifur Rahman, AKM Ahsan Habib, Md. Majdul Islam, Sayeeda Nusrat Sultana, Farzana Sohael, Nobutake Shimojo, Osamu Okazaki, Satoru Kawano
  • Journal Title: Endocrine Practice Volume: Supplementary issue Pages: 182-182
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh. (2015)
  • Author(s): 1.S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
  • Journal Title: European Heart Journal Volume: 36(1) Pages: 897-897
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of Circulatory Levels of Endothelin-1 in Diabetic Subjects Screened Through a Cross Sectional Study from Rural Women in Bangladesh. (2015)
  • Author(s): M.A. Rahman, S. Jesmin, C.N. Mowa, F. Sohael, J. Kamiyama, A.K.M.A. Habib, N. Shimojo, M.M. Islam, M. Moroi, O. Okazaki, N. Yamaguchi, S. Kawano, T. Mizutani, Y. Iwashima
  • Journal Title: International Journal of Diabetes and Clinical Research Volume: 2 Pages: 1-5
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh. (2015)
  • Author(s): S. Jesmin, M.A. Rahman, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Journal Title: Journal of Hypertension Volume: 33 Issue: Supplement 2 Pages: 2-2
  • DOI: 10.1097/01.hjh.0000469776.89393.2e
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of Circulatory Endothelin-1 Level among Preand Post-Menopausal Rural Women in Bangladesh: Result from a Population-Based Study. (2015)
  • Author(s): T. Khatun, S. Jesmin, N. Yamaguchi, J. Kamiyama, S. Akter, S.N. Sultana, M.M. Islam, O. Okazaki, S. Kawano, H. Akashi, T. Mizutani, T. Miyauchi, M.A. Rahman, A.K.M. A. Habib
  • Journal Title: Annals of Vascular Medicine and Research Volume: 2(2) Issue: 25-26 Pages: e68-e68
  • DOI: 10.1016/j.lfs.2014.01.030
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Assessment of Hypertension and the Associated Risk Factors in Postmenopausal Rural Women in Bangladesh: A Study from Basic Epidemiology to Biomarker Assessment. (2015)
  • Author(s): S. Jesmin, M.A. Rahman, S. Akter, M.M. Islam, T. Khatun, S.N. Sultana, S. Zaedi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Journal Title: Journal of Hypertension Volume: 33 Issue: Supplement 2 Pages: 1-1
  • DOI: 10.1097/01.hjh.0000469779.86715.a9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Low HDL in female acute coronary syndrome patient is alarming in Bangladesh. (2017)
  • Author(s): Subrina Jesmin, Osamu Okazaki, Arifur Rahman
  • Organizer: Specially arranged symposium at Bogra Medical college
  • Int'l Joint Research
• [Presentation] Prevention of low HDL and heart disease in Bangladesh: Effects of daily exercise intervention. (2017)
  • Author(s): Subrina Jesmin, Osamu Okazaki, Arifur Rahman
  • Organizer: Specially arranged symposium at HDRCRP, Dhaka
  • Int'l Joint Research
• [Presentation] バングラデシュにおける習慣的な歩行プログラムによる低HDL改善効果 (2016)
  • Author(s): Jesmin S, Md. Arifur Rahman, 小倉 かさね, 島 孟留, 松石 雄二朗, 下條 信威, 河野 了, 征矢 英昭
  • Organizer: Annual meeting of Japanese Society of Physical Fitness and Sports Medicine
  • Place of Presentation: 岩手
  • Year and Date: 2016-09-23
• [Presentation] Effects of endothelin receptor antagonism on VEGF signaling in diabetic penis: A possible clinical implication for diabetes erectile dysfunction. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Islam MM, Shimojo N, Sultana SN, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Diabetes induced cardiac VEGF system in estrogen/estrogen receptor manipulated animal model. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Islam MM, Shimojo N, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Prevalence of metabolic syndrome components among early age onset acute in coronary syndrome patients in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Shimojo N, Sultana SN, Sohael F, Okazaki O, Moroi M, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] National burden on non-communicable disease risk factors in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Sohael F, Shimojo N, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Gestational diabetes mellitus (GDM) in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Islam MM, Sohael F, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh, (2015)
  • Author(s): S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
  • Organizer: ESC Congress 2015
  • Place of Presentation: London, United Kingdom
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Nationwide Assessment of Hypertension Among the Adult Population in Bangladesh (2015)
  • Author(s): M.A. Rahman, S. Jesmin, M.M. Islam, S. Zaedi, A.S.H. Hasan, A.K.M.A. Habib, T. Khatun, S.N. Sultana, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Iwashima. A
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh (2015)
  • Author(s): M.A. Rahman, S. Jesmin, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Assessment of Hypertension and the Associated Risk Factors in Postmenopausal Rural Women in Bangladesh: A Study from Basic Epidemiology to Biomarker Assessment (2015)
  • Author(s): M.A. Rahman, S. Jesmin, S. Akter, M.M. Islam, T. Khatun, S.N. Sultana, S. Zaedi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Circulatory Level of Endothelin-1 and Hypertension in Rural Women in Bangladesh: A Potential Association Evidenced From a Community Based Cross-Sectional Study (2015)
  • Author(s): M.A. Rahman, S. Jesmin, M.M. Islam, F. Sohael, A.S.H. Hasan, S. Zaedi, S.N. Sultana, N. Yamaguchi, S. Kawano, O. Okazaki, A.K.M.A. Habib
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2015-06-04
  • Int'l Joint Research