Role of Nrf2 in Neutrophilic Allergic Athsma
| Project/Area Number |
15K08786
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Nippon Medical School |
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Principal Investigator |
LI YINGJI 日本医科大学, 医学部, 准教授 (60350039)
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| Co-Investigator(Kenkyū-buntansha) |
川田 智之 日本医科大学, 大学院医学研究科, 大学院教授 (00224791)
吾妻 安良太 日本医科大学, 医学部, 教授 (10184194)
平田 幸代 日本医科大学, 医学部, 助手 (40322515)
稲垣 弘文 日本医科大学, 医学部, 講師 (50213111)
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| Research Collaborator |
SHIMIZU Takako
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 酸化ストレス / アレルギー / 好中球 / 気道炎症 / 喘息 / アレルギー性気道炎症 |
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| Outline of Final Research Achievements |
In the present study, we investigated the role of Nrf2 on an experimental model of Ovalbumin (OVA) - sensitized and challenged allergic airway inflammation in both of BALB/c and C57BL/6 mice.
Nrf2+/+ and Nrf2－/－ mice were used in both of BALB/c and C57BL/6 mice. Allergic airway inflammation was generated in the mice by intraperitoneal sensitization with OVA/alum, and the mice were challenged with OVA intranasally. The several parameters such as inflammatory cytokines, IgE, and anti-oxidation index were examined in the bronchoalveolar lavage (BAL) fluid, serum, and lung tissues.
In conclusion, the role of Nrf2 in the generation of allergic airway inflammation differs markedly between mouse strains. Our results suggest that Nrf2 may play a key role in the development of allergic airway inflammation related to neutrophils in Th2 type BALB/c mice.
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Report
(4 results)
Research Products
(7 results)
