Exposure to mineral oil at working environment and autoimmunity

• Project/Area Number: 15K08790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: SATOH Minoru 産業医科大学, 産業保健学部, 教授 (90162487)
• Co-Investigator(Kenkyū-buntansha): 黒田 嘉紀 宮崎大学, 医学部, 教授 (50234620) ; 保利 一 産業医科大学, 産業保健学部, 教授 (70140902) ; 田中 晋 産業医科大学, 産業保健学部, 講師 (70280253)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 自己抗体 / 抗核抗体 / 自己免疫 / 鉱物油 / 労働環境 / 環境因子

Outline of Final Research Achievements

Humans are exposed to petroleum-derived mineral oils via food, cosmetics, medicine in daily life, exposure at working environment, environmental pollution and others. Mineral oils are generally believed inert and the effects of mineral oil exposure in human life have not been getting much attention. Development of lupus-like autoimmune syndrome as well as arthritis similar to rheumatoid arthritis, following an administration of pristane and other components of mineral oils, has been reported in mouse studies. An increased risk of rheumatoid arthritis among workers exposed to mineral oils also was reported. Nevertheless, little has been studied on the possible association between mineral oil exposure and autoimmunity in human. In this study, whether exposure to mineral oil at working environment is associated with production of autoantibodies associated with systemic autoimmune rheumatic diseases, was investigated.

Research Products

• [Journal Article] Detection of anti-mitochondrial antibodies by immunoprecipitation in patients with systemic sclerosis (2018)
  • Author(s): Ceribelli A, Isailovic N, De Santis M, Generali E, Satoh M, Selmi C
  • Journal Title: J Immunol Methods Volume: 452 Pages: 1-5
  • DOI: 10.1016/j.jim.2017.10.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Survival of Motor Neuron (SMN) Complex in a patient with necrotizing autoimmune myopathy (2018)
  • Author(s): Amlani A, Hazlewood GS, Hamilton L, Satoh M, Fritzler MJ
  • Journal Title: Rheumatology Volume: 57 Issue: 1 Pages: 199-200
  • DOI: 10.1093/rheumatology/kex392
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Immune-mediated thrombocytopenic purpura and hypothyroidism in a lung cancer patient treated with nivolumab (2018)
  • Author(s): Jotatsu T, Oda K, Kawanami T, Kido T, Satoh M, Yatera K
  • Journal Title: Immunotherapy Volume: 10 Issue: 2 Pages: 85-91
  • DOI: 10.2217/imt-2017-0100
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies (2018)
  • Author(s): S. Calise J, Zheng B, Hasegawa T, Satoh M, Isailovic N, Ceribelli A, Andrade LEC, Boylan K, Cavazzana I, Fritzler MJ, de la Torre IG, Hiepe F, Kohl K, Selmi C, Shoenfeld Y, Tincani A, Chan EKL, and the IUIS Autoantibody Standardization Committee
  • Journal Title: Clin Chem Lab Med Volume: 印刷中 Issue: 10 Pages: 1789-1798
  • DOI: 10.1515/cclm-2017-1152
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] International Consensus on Antinuclear Antibody Patterns on defining negative results and recommendation in reporting unidentified patterns (2018)
  • Author(s): Herold M, Klotz W, Andrade LEC, Conrad K, Damoiseaux J, Fritzler MJ, von Muhlen, Satoh M, Chan EKL and the other members of the Executive Committee of ICAP
  • Journal Title: Clin Chem Lab Med Volume: 印刷中 Issue: 10 Pages: 1799-1802
  • DOI: 10.1515/cclm-2018-0052
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Elevated α-defensin levels in plasma and bronchoalveolar lavage fluid from patients with myositis-associated interstitial lung disease (2018)
  • Author(s): Sakamoto Noriho、Ishimoto Hiroshi、Kakugawa Tomoyuki、Satoh Minoru、Hasegawa Tomoko、Tanaka Shin、Hara Atsuko、Nakashima Shota、Yura Hirokazu、Miyamura Takuto、Koyama Hanako、Morita Towako、Nakamichi Seiko、Obase Yasushi、Ishimatsu Yuji、Mukae Hiroshi
  • Journal Title: BMC Pulmonary Medicine Volume: 18 Issue: 1 Pages: 44-44
  • DOI: 10.1186/s12890-018-0609-5
  • NAID: 120006987302
  • Peer Reviewed / Open Access
• [Journal Article] A comprehensive overview on myositis-specific antibodies: New and old biomarkers in idiopathic inflammatory myopathy (2017)
  • Author(s): Satoh M, Tanaka S, Ceriblli A, Chan EKL
  • Journal Title: Clin Rev Allergy Immunol Volume: 52 Issue: 1 Pages: 1-19
  • DOI: 10.1007/s12016-015-8510-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Spontaneous Improvement of Interstitial Pneumonia with Autoimmune Features (2017)
  • Author(s): Oda K, Kawaguchi T, Satoh M, Yatera K
  • Journal Title: Internal Medicine Volume: 56 Issue: 12 Pages: 1607-1608
  • DOI: 10.2169/internalmedicine.56.8082
  • NAID: 130006856835
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Myositis-specific autoantibodies and their association with malignancy in Italian patients with polymyositis and dermatomyositis (2017)
  • Author(s): Ceribelli A, Isailovic N, De Santis M, Generali E, Fredi M, Cavazzana I, Franceschini F, Satoh M, Selmi C
  • Journal Title: Clin Rheumatol Volume: 36 Issue: 2 Pages: 469-475
  • DOI: 10.1007/s10067-016-3453-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Calcinosis in poly-dermatomyositis: clinical and laboratory predictors and treatment options (2017)
  • Author(s): Fredi M, Bartoli F, Cavazzana I, Ceribelli A, Carabellese N, Tincani A, Satoh M, Franceschini F
  • Journal Title: Clin Exp Rheumatol Volume: 35 Pages: 303-308
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] B cell tolerance to deiminated histones in BALB/c, C57BL/6, and autoimmune-prone mouse strains (2017)
  • Author(s): Dwivedi N, Hedberg A, Zheng YY, Neeli I, Satoh M, Morel L, Rekvig OP, Radic M
  • Journal Title: Frontiers Immunol Volume: 8 Pages: 362-362
  • DOI: 10.3389/fimmu.2017.00362
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autoantibodies to Su/Argonaute 2 in Japanese patients with inflammatory myopathy. (2017)
  • Author(s): Ogawa-Momohara M, Muro Y, Satoh M, Akiyama M.
  • Journal Title: Clin Chim Acta. Volume: 471 Pages: 304-307
  • DOI: 10.1016/j.cca.2017.06.022
  • Peer Reviewed
• [Journal Article] Clinical characteristics of patients with anti-aminoacyl-tRNA synthetase antibody positive idiopathic interstitial pneumonia (2017)
  • Author(s): Yura Hirokazu、Sakamoto Noriho、Satoh Minoru、Ishimoto Hiroshi、Hanaka Tetsuya、Ito Chiyo、Hasegawa Tomoko、Tanaka Shin、Miyamura Takuto、Nakashima Shota、Hara Atsuko、Kakugawa Tomoyuki、Oda Keishi、Kido Takashi、Obase Yasushi、Ishimatsu Yuji、Yatera Kazuhiro、Kawakami Atsushi、Mukae Hiroshi
  • Journal Title: Respiratory Medicine Volume: 132 Pages: 189-194
  • DOI: 10.1016/j.rmed.2017.10.020
  • Peer Reviewed
• [Journal Article] Associations between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004 (2016)
  • Author(s): Dinse GE, Jusko TA, Whitt IZ, Co CA, Parks CG, Satoh M, Chan EKL, Rose KM, Walker NJ, Birnbaum LS, Zeldin DC, Weinberg CR, Miller FW
  • Journal Title: Environ Health Perspect Volume: 124 Issue: 4 Pages: 426-36
  • DOI: 10.1289/ehp.1409345
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] International Consensus on ANA Patterns (ICAP): the bumpy road towards a consensus on reporting ANA results (2016)
  • Author(s): Damoiseaux J, von Muhlen CA, Garcia-De La Torre I, Carballo OG, de Melo Cruvinel W, Carvalho Francescantonio PL, Fritzler MJ, Herold M, Mimori T, Satoh M, Andrade LEC, Chan EKL, Conrad K
  • Journal Title: Autoimmun Highlights Volume: 7 Issue: 1 Pages: 1-1
  • DOI: 10.1007/s13317-016-0075-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015 (2016)
  • Author(s): Chan EKL, Damoiseaux J, de Melo Cruvinel W, Carballo OG, Conrad K, Carvalho Francescantonio PL, Fritzler MJ, Garcia-De La Torre I, Herold M, Mimori T, Satoh M, von Muhlen CA, Andrade LEC
  • Journal Title: Lupus Volume: 25 Pages: 797-804
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Testing for myositis specific autoantibodies: Comparison between line blot and immunoprecipitation assays in 57 myositis sera (2016)
  • Author(s): Cavazzana I, Fredi M, Ceribelli A, Mordenti C, Ferrari F, Carabellesse N, Tincani A, Satoh M, Franceschini F
  • Journal Title: J Immunol Methods Volume: 433 Pages: 1-5
  • DOI: 10.1016/j.jim.2016.02.017
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice (2016)
  • Author(s): Chukkapalli S, Rivera-Kweh M, Gehlot P, Velsko I, Bhattacharyya I, Calise JS, Satoh M, Chan EKL, Holoshitz J, Kesavalu L
  • Journal Title: Arthritis Res Ther Volume: 18 Issue: 1 Pages: 161-161
  • DOI: 10.1186/s13075-016-1056-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ethnic differences in autoantibody diversity and hierarchy: More clues from a US cohort of systemic sclerosis patients (2016)
  • Author(s): Nandiwada SN, Peterson LK, Mayes MD, Jaskowski TD, Malmberg E, Assassi S, Satoh M, Tebo AE
  • Journal Title: J Rheumatol Volume: 43 Issue: 10 Pages: 1816-24
  • DOI: 10.3899/jrheum.160106
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection (2016)
  • Author(s): Calise SJ, Bizzaro N, Nguyen T, Bassetti D, Porcelli B, Almi P, Barberio G, Pesce G, Satoh M, Chan EKL
  • Journal Title: Autoimmun Highlights Volume: 7 Issue: 1 Pages: 15-15
  • DOI: 10.1007/s13317-016-0087-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical subsets associated with different anti-aminoacyl transter RNA synthetase antibodies and their association with coexisting anti-Ro52. (2015)
  • Author(s): Yamasaki Y, Satoh M, Mizushima M, Okazaki T, Nagafuchi H, Ooka S, Shibata T, Nakano H, Ogawa H, Azuma K, Maeda A, Tonooka K, Ito H, Takakuwa Y, Inoue M, Kiyokawa T, Tsuchida K, Matsushita H, Mikage H, Murakami Y, Jason Y. F. Chan, Ozaki S, Yamada H.
  • Journal Title: Mod Rheumatol Volume: 1 Issue: 3 Pages: 403-9
  • DOI: 10.3109/14397595.2015.1091155
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Interleukin 1β-responsive microRNA-146a is critical for the cytokine-induced tolerance and cross-tolerance to toll-like receptor ligands (2015)
  • Author(s): Nahid MA, Satoh M, Chan EKL
  • Journal Title: J Innate Immun Volume: 7 Issue: 4 Pages: 428-40
  • DOI: 10.1159/000371517
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases (2015)
  • Author(s): Satoh M, Tanaka S, Chan EKL
  • Journal Title: Frontiers Immunol Volume: 6 Pages: 181-181
  • DOI: 10.3389/fimmu.2015.00181
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autoantibodies to the mitochondrial RNA processing (MRP) complex also known as Th/To autoantigen (2015)
  • Author(s): Mahler M, Fritzler MJ, Satoh M
  • Journal Title: Autoimmun Rev Volume: 14 Issue: 3 Pages: 254-7
  • DOI: 10.1016/j.autrev.2014.11.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Report of the First International Consensus on Antinuclear Antibody HEp-2 Cell Patterns (ICAP) Standardization, 2014-2015 (2015)
  • Author(s): Chan EKL, Damoiseaux J, Gabriel Carballo O, Conrad K, de Melo Cruvinel W, Carvalho Francescantonio PL, Fritzler MJ, Garcia-De La Torre I, Herold M, Mimori T, Satoh M, von Mühlen CA, Andrade LEC
  • Journal Title: Frontiers Immunol Volume: 6 Pages: 412-412
  • DOI: 10.3389/fimmu.2015.00412
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Autoantibodies in interstitial lung disease and lung cancer (2017)
  • Author(s): Minoru Satoh
  • Organizer: 13th Dresden Symposium on Autoantibodies and Autoimmunity
  • Int'l Joint Research / Invited
• [Book] Manual of Molecular and Clinical Laboratory Immunology, 8th edition (2016)
  • Author(s): Satoh M, Ceribelli A, Hirakata M, Chan EKL
  • Total Pages: 1240
  • Publisher: American Society of Microbiology Press
• [Book] Systemic Lupus Erythematosus (2016)
  • Author(s): Satoh M, Fritzler MJ, Chan EKL
  • Total Pages: 640
  • Publisher: Elsevier
• [Book] Vaccines and Autoimmunity (2015)
  • Author(s): Jara LJ, Medina G, del Pilar Cruz Dominguez M, Vera-Lastra O, Saavedra MA, Vazquez del Mercado M, Satoh M
  • Total Pages: 384
  • Publisher: John Wiley & Sons, Inc.
• [Book] Autoantigens, Autoantibodies, Autoimmunity Vol 10, From autoantibody research to standardized diagnostic assays in the management of human diseases (2015)
  • Author(s): Satoh M, Tanaka S, Chan EKL
  • Total Pages: 432
  • Publisher: Pabst Science Publishers