Risk prediction for gastric cancer using GWAS-identified polymorphisms, Helicobacter pylori infection and lifestyle-related risk factors in a Japanese population

• Project/Area Number: 15K08792
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Hidemi Ito 愛知県がんセンター(研究所), 遺伝子医療研究部, 室長 (90393123)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 胃がん / リスク予測 / 遺伝的要因 / 遺伝子多型 / ピロリ菌感染 / 喫煙 / 野菜果物摂取 / 個別化予防 / 環境要因

Outline of Final Research Achievements

We conducted two independent case-control studies, the first for model derivation (697 cases and 1,372 controls) and the second (678 and 678) for external validation. Using the derivation study data, we developed a prediction model by fitting a conditional logistic regression model using the following predictors: age, ABC classification defined by H.pylori infection and atrophic gastritis, smoking, fruit and vegetable intake, and selected GWAS-identified polymorphisms. Performance was assessed regarding discrimination (area under the curve, AUC).
A combination of four GWAS-identified polymorphisms and the other predictors provided high discriminatory accuracy in both studies, with AUCs of 0.79 (95% confidence intervals, 0.77-0.81) and 0.80 (0.77-0.82), respectively. This risk prediction model, which includes genetic, biological and lifestyle-related factors, might be useful in classifying Japanese into relevant risk groups of gastric cancer for personalized prevention programs.

Research Products

• [Int'l Joint Research] University of Milan/Mario Negri Institute/University of Cattolica(Italy)
• [Int'l Joint Research] UCLA Fielding School of Public Health/Icahn School of Medicine at Mount Sinai/University of Buffalo(米国)
• [Int'l Joint Research] University of Porto Medical School(ポルトガル)
• [Int'l Joint Research] University of Ottawa/Public Health Agency of Canada(Canada)
• [Int'l Joint Research] Lausanne University Hospital(Switzerland)
• [Int'l Joint Research]
• [Int'l Joint Research] University of Milan/Mario Negri Institute/University Cattolica(Italy)
• [Int'l Joint Research] University of Porto Medical School(Portugal)
• [Int'l Joint Research] University of Buffalo/Mount Sinai School of Medicine/UCLA Fielding School of Public Health(米国)
• [Int'l Joint Research] University of Ottawa/Public Health Agency of Canada(Canada)
• [Int'l Joint Research] Lausanne University Hospital(Switzerland)
• [Int'l Joint Research]
• [Journal Article] Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis. (2018)
  • Author(s): Ishioka K, Masaoka H, Ito H, Oze I, Ito S, Tajika M, Shimizu Y, Niwa Y, Nakamura S, Matsuo K.
  • Journal Title: Gastric Cancer Volume: 印刷中 Issue: 6 Pages: 936-945
  • DOI: 10.1007/s10120-018-0823-0
  • NAID: 40021694566
  • Peer Reviewed / Open Access
• [Journal Article] Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project. (2018)
  • Author(s): Praud D, Rota M, Pelucchi C, Bertuccio P, Rosso T, Galeone C, Zhang ZF, Matsuo K, Ito H, Boffetta P, Boccia S, Negri E, La Vecchia C, et al.
  • Journal Title: Eur J Cancer Prev Volume: 27(2) Issue: 2 Pages: 124-133
  • DOI: 10.1097/cej.0000000000000290
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Decrease in <i>PSCA</i> expression caused by <i>Helicobacter pylori</i> infection may promote progression to severe gastritis (2017)
  • Author(s): Toyoshima Osamu、Tanikawa Chizu、Yamamoto Ryuta、Watanabe Hidenobu、Yamashita Hiroharu、Sakitani Kosuke、Yoshida Shuntaro、Kubo Michiaki、Matsuo Keitaro、Ito Hidemi、Koike Kazuhiko、Seto Yasuyuki、Matsuda Koichi
  • Journal Title: Oncotarget. Volume: 9 Issue: 3 Pages: 3936-3945
  • DOI: 10.18632/oncotarget.23278
  • Peer Reviewed / Open Access
• [Journal Article] The more from East-Asian, the better: risk prediction of colorectal cancer risk by GWAS-identified SNPs among Japanese. (2017)
  • Author(s): Abe M, Ito H, Oze I, Nomura M, Ogawa Y, Matsuo K.
  • Journal Title: J Cancer Res Clin Oncol. Volume: 143(12) Issue: 12 Pages: 2481-2492
  • DOI: 10.1007/s00432-017-2505-4
  • Peer Reviewed
• [Journal Article] Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium. (2017)
  • Author(s): Rota M, Pelucchi C, Bertuccio P, Matsuo K, Zhang ZF, Ito H, Boffetta P, Boccia S, Negri E, La Vecchia C, et al.
  • Journal Title: Int J Cancer Volume: 141(10) Issue: 10 Pages: 1950-1962
  • DOI: 10.1002/ijc.30891
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: A nested case-control study within a large-scale population-based prospective study. (2016)
  • Author(s): Hidaka A, Sasazuki S, Matsuo K, Ito H, Charvat H, Sawada N, Shimazu T, Yamaji T, Iwasaki M, Inoue M, Tsugane S; JPHC Study Group..
  • Journal Title: Int J Cancer Volume: 139 (4) Issue: 4 Pages: 759-68
  • DOI: 10.1002/ijc.30130
  • Peer Reviewed
• [Journal Article] Molecular epidemiology, and possible real-world applications in breast cancer (2016)
  • Author(s): Ito H, Matsuo K
  • Journal Title: Breast Cancer Volume: 23(1) Issue: 1 Pages: 33-8
  • DOI: 10.1007/s12282-015-0609-8
  • Peer Reviewed / Open Access
• [Journal Article] Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population. (2016)
  • Author(s): Koyanagi YN, Ito H, Oze I, Hosono S, Tanaka H, Abe T, Shimizu Y, Hasegawa Y, Matsuo K
  • Journal Title: Eur J Cancer Prev. Volume: 印刷中 Issue: 1 Pages: 38-47
  • DOI: 10.1097/cej.0000000000000222
  • Peer Reviewed / Open Access
• [Journal Article] Declining trends in prevalence of Helicobacter pylori infection by birth-year in a Japanese population (2015)
  • Author(s): Watanabe M, Ito H, Hosono S, Oze I, Ashida C, Tajima K, Katoh H, Matsuo K, Tanaka H
  • Journal Title: Cancer Sci. Volume: 106(12) Issue: 12 Pages: 1738-43
  • DOI: 10.1111/cas.12821
  • Peer Reviewed / Open Access
• [Journal Article] A risk prediction model for colorectal cancer using genome-wide association study-identified polymorphisms and established risk factors among Japanese: results from two independent case-control studies. (2015)
  • Author(s): Hosono S, Ito H, Oze I, Watanabe M, Komori K, Yatabe Y, Shimizu Y, Tanaka H, Matsuo K.
  • Journal Title: Eur J Cancer Prev. Volume: 印刷中 Issue: 6 Pages: 500-507
  • DOI: 10.1097/cej.0000000000000213
  • Peer Reviewed
• [Presentation] Prediction of breast cancer risk based on common genetic variants in Japanes e women. (2017)
  • Author(s): Ito H, Iwasaki M, Koriyama C, Taniyama Y, Oze I, Imoto I, Ohno Y, Tsugane S, Iwata H, Matsuo K
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Risk prediction for gastric cancer using the GWAS-identified SNPs, Helicobacter pylori infection and lifestyle-related risk factors in a Japanese population (2016)
  • Author(s): Hidemi Ito, et al.
  • Organizer: Improving Cancer Risk Prediction for Prevention and Early Detection
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-11-16
  • Int'l Joint Research
• [Presentation] Risk prediction for stomach cancer using Helicobacter Pylori infection and Atrophic gastritis, fruits and vegetables, smoking and GWAS-identified genetic polymorphism (PSCA-rs2294008) in a Japanese population (2016)
  • Author(s): Hidemi Ito, et al.
  • Organizer: American Association for Cancer Research Annual Meeting
  • Place of Presentation: New Orleans
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] Risk prediction for stomach cancer using Helicobacter Pylori infection and Atrophic gastritis, fruits and vegetables, smoking and GWAS-identified genetic polymorphism (PSCA-rs2294008) in a Japanese population (2016)
  • Author(s): Hidemi Ito, Isao Oze, Satoyo Hosono, Mikik Watanabe, Hideo Tanaka, Keitaro Matsuo
  • Organizer: American Association for Cancer Research Annual Meeting
  • Place of Presentation: 米国ルイジアナ州ニューオーリンズ
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] Cumulative risks of stomach cancer by PSCA polymorphism, Helicobacter Pylori infection and smoking history in Japan (2015)
  • Author(s): Hidemi Ito, Isao Oze, Satoyo Hosono, Miki Watanabe, Hideo Tanaka, Keitaro Matsuo
  • Organizer: The 34th Sapporo International Cancer Symposium
  • Place of Presentation: ロイトン札幌（札幌市）
  • Year and Date: 2015-06-27
  • Int'l Joint Research