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Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella

Research Project

Project/Area Number 15K08794
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hygiene and public health
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Murakami Koichi  国立感染症研究所, 感染症疫学センター, 室長 (70446839)

Research Collaborator SHIGEMURA Hiroaki  福岡県保健環境研究所 (50761540)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsサルモネラ / 薬剤耐性 / 鶏肉 / Infantis / 血清型 / 基本再生産 / CMY-2 / TEM / CTX-M / 鶏 / セファロスポリン / AmpC / CMY
Outline of Final Research Achievements

Decreasing was detected in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry. Extended-spectrum cephalosporin (ESC)-resistant Salmonella in chicken meat is a significant food safety concern. The prevalence of ESC-resistant Salmonella inchicken meat products increased in Japan between 2005 and 2010. The prevalence of ESC-resistant Salmonella, mainly consisting of AmpC β-lactamase CMY-2-producing isolates, in chicken meat products had increased to 45.5% (10/22) by 2011. However, following the voluntary cessation of ceftiofur use by the Japanese poultry industry in 2012, the prevalence of ESC-resistant Salmonella steadily decreased each year, to 29.2% (7/24), 18.2% (4/22), 10.5% (2/19), and 10.5% (2/19) in 2012, 2013, 2014, and 2015, respectively. Furthermore, no AmpC β-lactamase CMY-2-producing isolates were identified in 2014 and 2015.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results)

  • [Journal Article] Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry2018

    • Author(s)
      Shigemura Hiroaki、Matsui Mari、Sekizuka Tsuyoshi、Onozuka Daisuke、Noda Tamie、Yamashita Akifumi、Kuroda Makoto、Suzuki Satowa、Kimura Hirokazu、Fujimoto Shuji、Oishi Kazunori、Sera Nobuyuki、Inoshima Yasuo、Murakami Koichi
    • Journal Title

      International Journal of Food Microbiology

      Volume: 274 Pages: 45

    • DOI

      10.1016/j.ijfoodmicro.2018.03.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulsed-field profile diversities of Salmonella Enteritidis, S. Infantis, and S. Corvallis in Japan2017

    • Author(s)
      Murakami K, Noda T, Onozuka D, Kimura H, Fujimoto S
    • Journal Title

      Italian Journal of Food Safety

      Volume: 6 Issue: 3 Pages: 138-144

    • DOI

      10.4081/ijfs.2017.6808

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks2017

    • Author(s)
      Murakami K, Maeda-Mitani E, Onozuka D, Noda T, Sera N, Kimura H, Fujimoto S, Murakami S
    • Journal Title

      Ir Vet J

      Volume: 70 Issue: 1

    • DOI

      10.1186/s13620-017-0105-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction of the prevalence of AmpC β-lactamase CMY-2 in Salmonella from chicken meat following cessation of the use of ceftiofur in Japan2017

    • Author(s)
      Kataoka Y, Murakami K, Torii Y, Kimura H, Maeda-Mitani E, Shigemura H, Fujimoto S, Murakami S:
    • Journal Title

      Journal of Global Antimicrobial Resistance

      Volume: 10 Pages: 10-11

    • DOI

      10.1016/j.jgar.2017.05.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食品・環境への薬剤耐性菌分布の拡大2017

    • Author(s)
      重村洋明・村上光一
    • Journal Title

      化学療法の領域

      Volume: 33 Pages: 41-49

    • Related Report
      2016 Research-status Report
  • [Journal Article] Typing Method for the QUB11a Locus of Mycobacterium tuberculosis: IS 6110 Insertions and Tandem Repeat Analysis2016

    • Author(s)
      Eriko Maeda-Mitani, Koichi Murakami, Akira Oishi, Yoshiki Etoh, Nobuyuki Sera, Shuji Fujimoto
    • Journal Title

      BioMed Research International

      Volume: 2016 Pages: 1-6

    • DOI

      10.1155/2016/5216530

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increase in resistance to extended-spectrum cephalosporins in Salmonella isolated from retail chicken products in Japan2015

    • Author(s)
      Noda T, Murakami K, Etoh Y, Okamoto F, Yatsuyanagi J, Sera N, Furuta M, Onozuka D, Oda T, Asai T, Fujimoto S.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 2 Pages: e0116927-e0116927

    • DOI

      10.1371/journal.pone.0116927

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 2.Phylogenetic assignment of Mycobacterium tuberculosis Beijing clinical isolates in Japan by maximum a posteriori estimation.2015

    • Author(s)
      Seto J, Wada T, Iwamoto T, Tamaru A, Maeda S, Yamamoto K, Hase A, Murakami K, Maeda E, Oishi A, Migita Y, Yamamoto T, Ahiko T
    • Journal Title

      Infect Genet Evol.

      Volume: 35 Pages: 82-88

    • DOI

      10.1016/j.meegid.2015.07.029

    • Related Report
      2015 Research-status Report
    • Peer Reviewed

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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