| Project/Area Number |
15K08794
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Murakami Koichi 国立感染症研究所, 感染症疫学センター, 室長 (70446839)
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| Research Collaborator |
SHIGEMURA Hiroaki 福岡県保健環境研究所 (50761540)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | サルモネラ / 薬剤耐性 / 鶏肉 / Infantis / 血清型 / 基本再生産 / CMY-2 / TEM / CTX-M / 鶏 / セファロスポリン / AmpC / CMY |
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| Outline of Final Research Achievements |
Decreasing was detected in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry. Extended-spectrum cephalosporin (ESC)-resistant Salmonella in chicken meat is a significant food safety concern. The prevalence of ESC-resistant Salmonella inchicken meat products increased in Japan between 2005 and 2010. The prevalence of ESC-resistant Salmonella, mainly consisting of AmpC β-lactamase CMY-2-producing isolates, in chicken meat products had increased to 45.5% (10/22) by 2011. However, following the voluntary cessation of ceftiofur use by the Japanese poultry industry in 2012, the prevalence of ESC-resistant Salmonella steadily decreased each year, to 29.2% (7/24), 18.2% (4/22), 10.5% (2/19), and 10.5% (2/19) in 2012, 2013, 2014, and 2015, respectively. Furthermore, no AmpC β-lactamase CMY-2-producing isolates were identified in 2014 and 2015.
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