Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella

• Project/Area Number: 15K08794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Murakami Koichi 国立感染症研究所, 感染症疫学センター, 室長 (70446839)
• Research Collaborator: SHIGEMURA Hiroaki 福岡県保健環境研究所 (50761540)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: サルモネラ / 薬剤耐性 / 鶏肉 / Infantis / 血清型 / 基本再生産 / CMY-2 / TEM / CTX-M / 鶏 / セファロスポリン / AmpC / CMY

Outline of Final Research Achievements

Decreasing was detected in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry. Extended-spectrum cephalosporin (ESC)-resistant Salmonella in chicken meat is a significant food safety concern. The prevalence of ESC-resistant Salmonella inchicken meat products increased in Japan between 2005 and 2010. The prevalence of ESC-resistant Salmonella, mainly consisting of AmpC β-lactamase CMY-2-producing isolates, in chicken meat products had increased to 45.5% (10/22) by 2011. However, following the voluntary cessation of ceftiofur use by the Japanese poultry industry in 2012, the prevalence of ESC-resistant Salmonella steadily decreased each year, to 29.2% (7/24), 18.2% (4/22), 10.5% (2/19), and 10.5% (2/19) in 2012, 2013, 2014, and 2015, respectively. Furthermore, no AmpC β-lactamase CMY-2-producing isolates were identified in 2014 and 2015.

Research Products

• [Journal Article] Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry (2018)
  • Author(s): Shigemura Hiroaki、Matsui Mari、Sekizuka Tsuyoshi、Onozuka Daisuke、Noda Tamie、Yamashita Akifumi、Kuroda Makoto、Suzuki Satowa、Kimura Hirokazu、Fujimoto Shuji、Oishi Kazunori、Sera Nobuyuki、Inoshima Yasuo、Murakami Koichi
  • Journal Title: International Journal of Food Microbiology Volume: 274 Pages: 45-51
  • DOI: 10.1016/j.ijfoodmicro.2018.03.011
  • Peer Reviewed
• [Journal Article] Pulsed-field profile diversities of Salmonella Enteritidis, S. Infantis, and S. Corvallis in Japan (2017)
  • Author(s): Murakami K, Noda T, Onozuka D, Kimura H, Fujimoto S
  • Journal Title: Italian Journal of Food Safety Volume: 6 Issue: 3 Pages: 138-144
  • DOI: 10.4081/ijfs.2017.6808
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks (2017)
  • Author(s): Murakami K, Maeda-Mitani E, Onozuka D, Noda T, Sera N, Kimura H, Fujimoto S, Murakami S
  • Journal Title: Ir Vet J Volume: 70 Issue: 1
  • DOI: 10.1186/s13620-017-0105-x
  • Peer Reviewed / Open Access
• [Journal Article] Reduction of the prevalence of AmpC β-lactamase CMY-2 in Salmonella from chicken meat following cessation of the use of ceftiofur in Japan (2017)
  • Author(s): Kataoka Y, Murakami K, Torii Y, Kimura H, Maeda-Mitani E, Shigemura H, Fujimoto S, Murakami S:
  • Journal Title: Journal of Global Antimicrobial Resistance Volume: 10 Pages: 10-11
  • DOI: 10.1016/j.jgar.2017.05.003
  • Peer Reviewed
• [Journal Article] 食品・環境への薬剤耐性菌分布の拡大 (2017)
  • Author(s): 重村洋明・村上光一
  • Journal Title: 化学療法の領域 Volume: 33 Pages: 41-49
• [Journal Article] Typing method for the QUB11a locus of Mycobacterium tuberculosis: IS6110 insertions and tandem repeat analysis (2016)
  • Author(s): Eriko Maeda-Mitani, Koichi Murakami, Akira Oishi, Yoshiki Etoh, Nobuyuki Sera, Shuji Fujimoto
  • Journal Title: BioMed Research International Volume: 2016 Pages: 1-6
  • DOI: 10.1155/2016/5216530
  • Peer Reviewed / Open Access
• [Journal Article] Increase in resistance to extended-spectrum cephalosporins in Salmonella isolated from retail chicken products in Japan. (2015)
  • Author(s): Noda T, Murakami K, Etoh Y, Okamoto F, Yatsuyanagi J, Sera N, Furuta M, Onozuka D, Oda T, Asai T, Fujimoto S.
  • Journal Title: PLoS One Volume: 10 Issue: 2 Pages: e0116927-e0116927
  • DOI: 10.1371/journal.pone.0116927
  • Peer Reviewed / Open Access
• [Journal Article] 2.Phylogenetic assignment of Mycobacterium tuberculosis Beijing clinical isolates in Japan by maximum a posteriori estimation. (2015)
  • Author(s): Seto J, Wada T, Iwamoto T, Tamaru A, Maeda S, Yamamoto K, Hase A, Murakami K, Maeda E, Oishi A, Migita Y, Yamamoto T, Ahiko T
  • Journal Title: Infect Genet Evol. Volume: 35 Pages: 82-88
  • DOI: 10.1016/j.meegid.2015.07.029
  • Peer Reviewed