| Project/Area Number |
15K08796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
Gamage Chandika D ペラデニア大学, 医学部, Senior Lecturer
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 人獣共通感染症 / ハンタウイルス感染症 / レプトスピラ / 慢性腎臓病 / スリランカ / CKDu / げっ歯類媒介性 / ハンタウイルス / インフルエンザ様疾患 / 不明熱 / 腎臓疾患 / 肝臓障害 / げっ歯類 / トガリネズミ / 慢性腎臓疾患 |
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| Outline of Final Research Achievements |
To clarify the mode and host of Leptospira and hantavirus infection, rat-trapping in Sri Lanka was carried out. Pathogenic strains of Leptospires were isolated from rats and shrews. And high seroprevalence (19%) of anti-hantavirus antibody among black rats was found in rural area, Girandrukotte. In Sri Lankan endemic strain of rat was considered to be a host for Thailand virus-related hantavirus. Around 50% of chronic kidney disease by unknown etiology (CKDu) patients were seropositive to hantavirus, while 5% for healthy people in CKDu non-endemic area. In this study, in Sri Lanka, it was shown that Leptospira and hantavirus infection occurred frequently from endemic rats as the infection source, and furthermore, hantavirus infection could be the risk of progression of CKDu.
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