| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Among 421 men (mean 50.7 ± 6.1 years) who had no history of diabetes, hypertension, or abnormal lipid metabolism, the association between birth weight and the methylation of the ATP-binding cassette protein A1 (ABCA1) gene was examined to elucidate the epidemiological pathology of lifestyle-related diseases based on epigenetics theory. The ATP-binding cassette protein A1 (ABCA1) plays an important role in HDL cholesterol production. The methylation rate of DNA was significantly higher in the group of less than 2500 g compared to the group of 2500 g or more among the subjects at age 50 and older, while there was no significant difference between the two groups among those under the age of 50. This finding suggests that the bad prenatal environment may promote the DNA methylation rate of ABCA1 gene in the second half of adulthood.
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