Markers of chronic kidney disease in the general population

• Project/Area Number: 15K08805
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Osaka University
• Principal Investigator: Cui Renzhe 大阪大学, 医学系研究科, 助教 (40375514)
• Co-Investigator(Kenkyū-buntansha): 木山 昌彦 公益財団法人大阪府保健医療財団大阪がん循環器病予防センター(予防推進部・循環器病予防健診部・健康開発, その他部局等, その他 (10450925) ; 磯 博康 大阪大学, 医学系研究科, 教授 (50223053) ; 大平 哲也 福島県立医科大学, 医学部, 教授 (50448031) ; 北村 明彦 大阪大学, 医学系研究科, 招へい准教授 (80450922)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: FMD検査 / 血管内皮機能障害 / 早期腎臓障害 / 疫学研究 / 血管内皮機能 / 慢性腎臓病 / 中心動脈圧 / シスタチンC

Outline of Final Research Achievements

We examined the associations of augmentation index (AI) with atrial fibrillation, and brachial artery flow-mediated dilation (FMD) with chronic renal disease in the general population. AI values were positively associated with the prevalence of atrial fibrillation, independent of cardiovascular risk factors. Also, low FMD values tended to inversely associated with the prevalence of chronic renal disease.

Research Products

• [Journal Article] Association between markers of arterial stiffness and atrial fibrillation in the Circulatory Risk in Communities Study (CIRCS). (2017)
  • Author(s): Cui R, Yamagishi K, Muraki I, Hayama-Terada M, Umesawa M, Imano H, Li Y, Eshak ES, Ohira T, Kiyama M, Okada T, Kitamura A, Tanigawa T, Iso H; CIRCS investigators.
  • Journal Title: Atherosclerosis Volume: 263 Pages: 244-248
  • DOI: 10.1016/j.atherosclerosis.2017.06.918
  • NAID: 120007128953
  • Peer Reviewed
• [Journal Article] Associations of central aortic pressure and brachial blood pressure with flow mediated dilatation in apparently healthy Japanese men: The Circulatory Risk in Communities Study (CIRCS) (2016)
  • Author(s): Liu K, Cui R, Eshak ES, Cui M, Dong JY, Kiyama M, Okada T, Kitamura A, Umesawa M, Yamagishi K, Imano H, Ohira T, Iso H.
  • Journal Title: Atherosclerosis Volume: 259 Pages: 46-50
  • DOI: 10.1016/j.atherosclerosis.2017.02.024
  • NAID: 120007128957
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Heavy Alcohol Consumption is Associated with Impaired Endothelial Function: (2016)
  • Author(s): Tanaka A, Cui R, Kitamura A, Liu K, Imano H, Yamagishi K, Kiyama M, Okada T, Iso H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 9 Pages: 1047-1054
  • DOI: 10.5551/jat.31641
  • NAID: 130005261986
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Trends in the proportions of stroke subtypes and coronary heart disease in the Japanese men and women from 1995 to 2009 (2016)
  • Author(s): Cui R, Iso H, Yamagishi K, Saito I, Kokubo Y, Inoue M, Sawada N, Tsugane S
  • Journal Title: Atherosclerosis Volume: 248 Pages: 219-223
  • DOI: 10.1016/j.atherosclerosis.2016.03.001
  • NAID: 120007129633
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum albumin and high-sensitivity C-reactive protein are independent risk factors of chronic kidney disease in middle-aged Japanese individuals: the Circulatory Risk in Communities Study (2016)
  • Author(s): Kubo S, Kitamura A, Imano H, Cui R, Yamagishi K, Umesawa M, Muraki I, Kiyama M, Okada T, Iso H
  • Journal Title: J Atheroscler Thromb Volume: 23
  • NAID: 130005261989
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Profile of Non-communicable Disease Risk Factors Among Young People in Palau (2015)
  • Author(s): Chiang C, Singeo ST Jr, Yatsuya H, Honjo K, Mita T, Ikerdeu E, Cui R, Li Y, Watson BM, Ngirmang G, Iso H, Aoyama A
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 5 Pages: 392-397
  • DOI: 10.2188/jea.JE20140156
  • NAID: 130005067870
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Urinary sodium and potassium excretion in relation to risk of stroke in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS) (2016)
  • Author(s): Cui R, Yamagishi K, Imano H, et al.
  • Organizer: American Heart Association 51th Annual Conference on Cardiovascular Disease Epidemiology and Prevention
  • Place of Presentation: Phoenix, Arizona USA
  • Year and Date: 2016-03-01
  • Int'l Joint Research
• [Presentation] 中心動脈圧、AIと眼底異常との関連 (2015)
  • Author(s): 崔仁哲、Gero Krisztina、劉克洋、山岸良匡、梅澤光政、今野弘規、大平哲也、木山昌彦、岡田武夫、北村明彦、山海知子、磯博康.
  • Organizer: 第15回 臨床血圧脈波研究会
  • Place of Presentation: 新大阪
  • Year and Date: 2015-06-20
• [Book] Alcohol and sleep-disordered breathing. In: Watson RR, editors. Modulation of sleep by obesity, age, and diet. (2015)
  • Author(s): Cui R, Iso H
  • Total Pages: 385
  • Publisher: Academic Press is an imprint of Elsevier