A longitudinal study of epigenetic epidemiology for the primary and secondary prevention of elderly depression

• Project/Area Number: 15K08824
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Toho University
• Principal Investigator: IHARA Kazushige 東邦大学, 医学部, 講師 (10266083)
• Co-Investigator(Kenkyū-buntansha): 森信 繁 吉備国際大学, 保健医療福祉学部, 教授 (30191042) ; 吉田 英世 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (00242735) ; 淵上 学 広島大学, 学内共同利用施設等, 助教 (40403571) ; 大渕 修一 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50265740)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: エピジェネティクス / 疫学 / 大うつ病性障害 / 小うつ病性障害 / メチル化障害 / 高齢者 / SCID / 縦断研究 / うつ病 / DNAメチル化 / DSM-Ⅳ / BDNF / DNAメチル化障害 / DSM-IV

Outline of Final Research Achievements

We cross-sectionally and longitudinally examined the association between major depressive disorder (MDD) and the DNA methylation rates (DMRs) of brain-derived neurotrophic factor (BDNF) gene in blood among the elderly. Through epidemiologic surveys, psychiatrists identified incident/current-episode cases of MDD and non-depressed controls. Cross-sectional analyses using current-episode cases and controls revealed that DMRs of some units at the CpG island at the promoter of exon I of the BDNF gene were significantly different between persons with MDD and controls. A case-control study using incident cases and controls revealed that DMRs of some CpG units of the BDNF gene in blood preserved at a survey when MDD had not developed yet were significantly different from DMRs of controls using blood at the same survey which blood for corresponding cases were preserved. We additionally explored the correlation between DMRs of CpG units of the BDNF gene and age among non-depressed persons.

Research Products

• [Journal Article] The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood. (2018)
  • Author(s): K. Ihara, M. Fuchikami, M. Hashizume, S. Okada, H. Kawai, S. Obuchi, H. Hirano, Y. Fujiwara, M. Hachisu, H. Kim, S. Morinobu
  • Journal Title: International Journal of Geriatric Psychiatry Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Serum BDNF levels before and after the development of mood disorders: a case-control study in a population cohort (2016)
  • Author(s): Ihara K, Yoshida H, Jones PB, Hashizume M, Suzuki Y, Ishijima H, Kim H, Suzuki T, Hashizume M
  • Journal Title: Translational Psychiatry Volume: 6 Issue: 4 Pages: e782-e782
  • DOI: 10.1038/tp.2016.47
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Classification of frailty using the Kihon checklist: A cluster analysis of older adults in urban areas. (2016)
  • Author(s): Kera T, Kawai H, Yoshida H, Hirano H, Kojima M, Fujiwara Y, Ihara K, Obuchi S
  • Journal Title: Geratrics & Gerontology International Volume: in printing Issue: 1 Pages: 1-9
  • DOI: 10.1111/ggi.12676
  • Peer Reviewed / Open Access
• [Presentation] Knee muscle strength, neither vitamin D nor high-sensitive CRP, was a risk factor for major depressive disorder among elderly women. (2017)
  • Author(s): Ihara K, Hashizume M, Suzuki T, Kim H
  • Organizer: The 16th International Congress of the International Federation of Psychiatric Epidemiology.
  • Int'l Joint Research
• [Presentation] コホート内症例対照研究によるフレイルの大うつ病性障害発症に対する影響の検討 (2016)
  • Author(s): 井原一成、飯田浩毅、鈴木友理子、長谷川千絵、藤田欣也、天野雄一、端詰勝敬、蜂須貢、大庭輝、金憲経、吉田英世
  • Organizer: 第７５回日本公衆衛生学会総会
  • Place of Presentation: グランフロント大阪、大阪市、大阪府
  • Year and Date: 2016-10-27
• [Presentation] 地域在住高齢者におけるフレイルとBDNF（脳由来神経栄養因子）との関連性の検討 (2015)
  • Author(s): 吉田英世、井原一成、端詰勝敬、吉田祐子、小島成実、金美芝、平野浩彦、金憲経、蜂須貢
  • Organizer: 第74回日本公衆衛生学会総会
  • Place of Presentation: 長崎ブリックホール（長崎県長崎市）
  • Year and Date: 2015-11-06